Choline chloride-based deep eutectic solvents (NADES): Potential use as green extraction media for polyphenols from Mentha pulegium, antioxidant activity, and antifungal activity

Soukaina, Kaoui; Safa, Zaidouni; Soukaina, Harif; Hicham, Chebli; Bouchra, Chebli

doi:10.1016/j.microc.2024.110174

Cited by 16 publications

(3 citation statements)

References 60 publications

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“…As a novelty, the profile of the (poly)phenols has been used to select critical factors in the UAE. Authors typically use the spectrophotometric method to optimize or study the most crucial factors that affect extraction methods, such as total phenol content, total flavonoid content, or anthocyanin content ( Chebbi et al, 2024 ; Lee et al, 2024 ; Soukaina et al, 2024 ). However, investigating the effect of different variables on the (poly)phenol profile is relevant to maximize the extraction of target compounds in plant materials.…”

Section: Discussionmentioning

confidence: 99%

Screening factors to affect ultrasound-assisted extraction of (poly)phenols from date palm seeds

Lucas-González,

Viuda-Martos,

Pérez-Álvarez

et al. 2024

Front. Chem.

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The aim of the current work was to compare the (poly)phenol profile (free, soluble-conjugate, and insoluble-bound) and antioxidant activity of date palm seed flour using different extraction methods (conventional vs. ultrasound-assisted extraction [UAE]) and to determine the most critical variables in the extraction of (poly)phenols through UAE using the Plackett–Burman design experiment. Using the Plackett–Burman design, seven factors, namely, ethanol concentration, liquid:solid ratio (mL/g), sonotrode, amplitude (%), extraction time, extractant pH, and extraction cycle, were studied. After the factors were studied using conventional extraction methods, 23 compounds were quantified, with protocatechuic acid and catechin being the predominant (poly)phenols. Furthermore, the distribution of (poly)phenols within the cell varied, with glycosylated quercetins and caffeoyl shikimic acids predominantly found in free forms. Ultrasound-assisted extraction demonstrated efficiency in extracting free and soluble-conjugate (poly)phenols. However, it showed limitations in extracting insoluble-bound (poly)phenols. Nevertheless, similar amounts of total (poly)phenols were shown after conventional extraction and UAE, that is, 259.69 ± 43.54 and 189.00 ± 3.08 mg/100 g date seed flour, respectively. The Plackett–Burman design revealed the liquid–solid ratio as a crucial factor affecting (poly)phenol extraction, with higher ratios yielding better results. The sonotrode choice also influenced the extraction efficiency, highlighting that the sonotrode with a smaller diameter but higher displacement amplitude showed the best polyphenol recovery and antioxidant activity values. The nature of (poly)phenols influenced the studied extraction variables differently, emphasizing the complexity of the extraction process. In this line, pure water was sufficient to extract flavan-3-ols after UAE, whereas ethanol was a crucial factor in extracting quercetin. These findings underscore the importance of optimizing extraction methods for maximizing (poly)phenol recovery from date palm seed flour for various applications in food and pharmacology industries.

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Section: Discussionmentioning

confidence: 99%

Screening factors to affect ultrasound-assisted extraction of (poly)phenols from date palm seeds

Lucas-González,

Viuda-Martos,

Pérez-Álvarez

et al. 2024

Front. Chem.

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“…In the work of Soukina et al [63], the combination of choline chloride and lactic acid achieved the highest yield of polyphenols compared to the other six types of solvents used to extract polyphenols from Mentha pulegium.…”

Section: Introductionmentioning

confidence: 98%

“…Additionally, hydrogen bond donors play a crucial role, and substances like urea, imidazole derivatives, amides, alcohols, and organic carboxylic acids are commonly employed. These solvents achieve promising results in the extraction of various classes of active substances, especially phenols [63][64][65][66][67][68].…”

Section: Introductionmentioning

confidence: 99%

Analyzing the Effect of Extraction Parameters on Phenolic Composition and Selected Compounds in Clove Buds Using Choline Chloride and Lactic Acid as Extraction Agents

Strižincová,

Šurina,

Jablonský

et al. 2024

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Utilizing a deep eutectic solvent-like mixture such as choline chloride and lactic acid in a 1:2 molar ratio, clove buds underwent extraction. Furthermore, the determination of the primary components in the clove extracts, namely eugenol, eugenol acetate, and β-caryophyllene, was conducted using the HPLC-DAD method. The total phenolic content (TPC) was also established. Extraction conditions using choline chloride and lactic acid encompassed variables such as extraction temperature (within the range of 40 to 80 °C), water addition (ranging from 5.6 to 40%), and extraction time (ranging from 30 to 90 min). Optimal operational conditions for TPC were pinpointed at 77 °C, 30 min, and a water addition of 40%. The findings showed that clove extracts obtained at 60 °C, 22.8%, and 30 min had the highest amount of eugenol (307.26 ± 8.44 mg/g dry raw material).

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Green analytical chemistry in sample preparation

Acebal,

Lorenzetti,

Abellán-Martín

et al. 2024

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

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Choline chloride-based deep eutectic solvents (NADES): Potential use as green extraction media for polyphenols from Mentha pulegium, antioxidant activity, and antifungal activity

Cited by 16 publications

References 60 publications

Screening factors to affect ultrasound-assisted extraction of (poly)phenols from date palm seeds

Screening factors to affect ultrasound-assisted extraction of (poly)phenols from date palm seeds

Analyzing the Effect of Extraction Parameters on Phenolic Composition and Selected Compounds in Clove Buds Using Choline Chloride and Lactic Acid as Extraction Agents

Green analytical chemistry in sample preparation

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