Choline chloride-based natural deep eutectic solvents for the extraction and stability of phenolic compounds, ascorbic acid, and antioxidant capacity from Citrus sinensis peel

Gómez-Urios, Clara; Viñas-Ospino, Adriana; Puchades-Colera, Pablo; Blesa, Jesús; López-Malo, Daniel; Frígola, Ana; Esteve, María J.

doi:10.1016/j.lwt.2023.114595

Cited by 42 publications

(9 citation statements)

References 50 publications

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“…Notably, there was no significant difference ( p >0.05) between the pH of DES synthesized by microwave and conventional methods. However, the pH of ChCl:MA DES measured in the current study was higher than that measured by Gómez‐Urios et al [21] . This difference could be due to several factors such as the measuring temperature, water content (or concentration of DES) and molar ratio.…”

Section: Resultscontrasting

confidence: 90%

Microwave‐Assisted Preparation of an Acidic Deep Eutectic Solvent: Green Analysis, Characterization and Application

Yap,

Wang,

Gan

2024

ChemistrySelect

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Microwave irradiation was postulated to reduce time and energy for deep eutectic solvent (DES) production which is in line with the principle of green chemistry. In this study, the choline chloride (ChCl)‐malic acid (MA) DES was prepared using microwave‐assisted (DES‐Mic) and conventional (DES‐Con) approaches. Microwave was a relatively greener approach as it was rapid (5 min) and consumed 92.8 % energy less than DES‐Con. Moreover, DES‐Mic and DES‐Con exhibited similar physicochemical profiles (pH, solubility, density) and rheological properties. Structural profiling through FTIR analysis suggested hydrogen bond formation between the functional groups of ChCl and MA. The FTIR spectra also did not show structural differences in the DES synthesized using different methods. DES‐Mic and DES‐Con exhibited superior 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) (80.8±0.1 and 83.2±0.3 %, respectively) free radical scavenging activities than ChCl (15.6±0.8 %), MA (20.0±1.4 %) and ChCl:MA aqueous mixture without subjected to DES synthesis conditions (ChCl:MAaq; 23.3±0.8 %). Both DES were also proven as more efficient solvents for the extraction of polysaccharides from ramie leaf, as they recorded higher yields (21.4±1.9 and 22.2±1.0 %, respectively) than equimolar of MA (17.7±2.6 %) and ChCl (6.4±0.2 %). Overall, microwave was proven as a more sustainable approach for DES preparation compared to conventional method, which could be further improvised for industrial applications.

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Section: Resultscontrasting

confidence: 90%

Microwave‐Assisted Preparation of an Acidic Deep Eutectic Solvent: Green Analysis, Characterization and Application

Yap,

Wang,

Gan

2024

ChemistrySelect

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“…Some studies were performed to study this parameter and found that the DESs extracts have a longer shelf-life when compared with conventional solvents extracts [ 129 , 180 ]. This stabilization was due to the ability of the DESs to stabilize the phenolic compounds [ 185 ]. Lee et al [ 160 ] used leaves from kale to extract several health-promoting phytochemicals using natural DESs with different hydrophilicity/hydrophobicity.…”

Section: Deep Eutectic Solvents For the Extraction Of Bioactive Compo...mentioning

confidence: 99%

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Ferreira,

Sarraguça

2024

Pharmaceuticals

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The extraction of bioactive compounds of pharmaceutical interest from natural sources has been significantly explored in recent decades. However, the extraction techniques used were not very efficient in terms of time and energy consumption; additionally, the solvents used for the extraction were harmful for the environment. To improve the environmental impact of the extractions and at the same time increase the extraction yields, several new extraction techniques were developed. Among the most used ones are ultrasound-assisted extraction and microwave-assisted extraction. These extraction techniques increased the yield and selectivity of the extraction in a smaller amount of time with a decrease in energy consumption. Nevertheless, a high volume of organic solvents was still used for the extraction, causing a subsequent environmental problem. Neoteric solvents appeared as green alternatives to organic solvents. Among the neoteric solvents, deep eutectic solvents were evidenced to be one of the best alternatives to organic solvents due to their intrinsic characteristics. These solvents are considered green solvents because they are made up of natural compounds such as sugars, amino acids, and carboxylic acids having low toxicity and high degradability. In addition, they are simple to prepare, with an atomic economy of 100%, with attractive physicochemical properties. Furthermore, the huge number of compounds that can be used to synthesize these solvents make them very useful in the extraction of bioactive compounds since they can be tailored to be selective towards a specific component or class of components. The main aim of this paper is to give a comprehensive review which describes the main properties, characteristics, and production methods of deep eutectic solvents as well as its application to extract from natural sources bioactive compounds with pharmaceutical interest. Additionally, an overview of the more recent and sustainable extraction techniques is also given.

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“…As mentioned removal of phenolic pollutants by using cost-efficient and eco-friendly techniques is challenging at present. The highly watersoluble and stable nature of phenolic compounds makes their degradation from wastewater more challenging using common techniques 12,13 .…”

Section: Leila Razavi Heidar Raissi Ozra Hashemzehi and Farzaneh Farzadmentioning

confidence: 99%

Significantly enhanced performance for phenol compounds removal by MOF-5 nano-composite via its surface modification

Razavi,

Raissi,

Hashemzehi

et al. 2024

npj Clean Water

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The present study is focused on the use of cubic metal-organic frameworks-5 (MOF-5) and its functionalized form in the removal of phenolic pollutants by molecular dynamics (MD) and Well-tempered metadynamics (WTMD) simulation methods. It was found that the adsorption mechanism of MOF-5s/phenolic compounds is mostly due to the van der Waals and π–π interactions. However, electrostatic and hydrogen bond (HB) interactions also play a significant role in removing phenolic pollutants by MOF-5 and its functionalized form. The results show that the fluorine functional group (F-MOF-5) increases the adsorption capacity of phenol compounds on the adsorbent surface. By functionalizing the MOF-5 with a methyl functional group (CH3-MOF-5), the adsorption strength decreases. The WTMD calculation confirmed that at the most stable state, the free energy (FE) value of system II (the most stable system in functionalized systems with –F functional group) is about −289.528 kJ mol−1. This value is ~5.781 and 35.514 kJ mol−1 more negative than the FE of the I and III systems (the most stable systems in the pristine and CH3-MOF-5/pollutant systems, respectively). Altogether, the results indicate that F-MOF-5 can be considered a more suitable adsorbent than MOF-5 and CH3-MOF-5 for phenolic pollutants removal from the environment for more assessment.

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Choline chloride-based natural deep eutectic solvents for the extraction and stability of phenolic compounds, ascorbic acid, and antioxidant capacity from Citrus sinensis peel

Cited by 42 publications

References 50 publications

Microwave‐Assisted Preparation of an Acidic Deep Eutectic Solvent: Green Analysis, Characterization and Application

Microwave‐Assisted Preparation of an Acidic Deep Eutectic Solvent: Green Analysis, Characterization and Application

A Comprehensive Review on Deep Eutectic Solvents and Its Use to Extract Bioactive Compounds of Pharmaceutical Interest

Significantly enhanced performance for phenol compounds removal by MOF-5 nano-composite via its surface modification

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