Choline deficiency-related multi-omics characteristics are susceptible factors for chemotherapy-induced thrombocytopenia

Yao, Houshan; Xu, Huilin; Qiu, Shi; Chen, Jiani; Lin, Zeshuai; Zhu, Jiawei; Sun, Xiaomeng; Gao, Qianmin; Chen, Xintao; Xi, Chaowen; Huang, Doudou; zhang, Feng; Gao, Shouhong; Wang, Zhipeng; Zhang, Jian; Liu, Xuan; Ren, Guoliang; Xia, Tao; Li, Mingming; Chen, Wansheng

doi:10.1016/j.phrs.2022.106155

Cited by 2 publications

(3 citation statements)

References 62 publications

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Section: Introductionmentioning

confidence: 99%

“…Nausea and vomiting (NV), hand-foot syndrome (HFS), and bone marrow suppression (BMS) are the 3 common adverse effects caused by capecitabine according to literatures and our ongoing observational clinical trial. [4][5][6][7][8][9][10] These CIAEs hamper the successful completion of anti-cancer treatment, bringing a highly burdensome condition for patients, and even threaten life if left untreated. 11 In order to facilitate clinicians to develop personalized treatment strategies through CIAE prediction, it is urgent to identify all the important risk factors for CIAEs.…”

Section: Introductionmentioning

confidence: 99%

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Milk and Egg Are Risk Factors for Adverse Effects of Capecitabine-Based Chemotherapy in Chinese Colorectal Cancer Patients

Lin

Chen

et al. 2022

Integr Cancer Ther

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Background: Chemotherapy-induced adverse effects (CIAEs) remain a challenging problem due to their high incidences and negative impacts on treatment in Chinese colorectal cancer (CRC) patients. We aimed to identify risk factors and predictive markers for CIAEs using food/nutrition data in CRC patients receiving post-operative capecitabine-based chemotherapy. Methods: Food/nutrition data from 130 Chinese CRC patients were analyzed. Univariate and multivariate analyses were used to identify CIAE-related food/nutrition factors. Prediction models were constructed based on the combination of these factors. The area under the receiver operating characteristic curve (AUROC) was used to evaluate the discrimination ability of models. Results: A total of 20 food/nutrition factors associated with CIAEs were identified in the univariate analysis after adjustments for total energy and potential confounding factors. Based on multivariate analysis, we found that, among these factors, dessert, eggs, poultry, and milk were associated with several CIAEs. Most importantly, poultry was an overall protective factor; milk and egg were risk factors for hand-foot syndrome (HFS) and bone marrow suppression (BMS), respectively. Developed multivariate models in predicting grade 1 to 3 CIAEs and grade 2/3 CIAEs both had good discrimination (AUROC values from 0.671 to 0.778, 0.750 to 0.946 respectively), which had potential clinical application value in the early prediction of CIAEs, especially for more severe CIAEs. Conclusions: Our findings suggest that patients with high milk and egg intakes should be clinically instructed to control their corresponding dietary intake to reduce the likelihood of developing HFS and BMS during capecitabine-based chemotherapy, respectively. Trial registration: ClinicalTrials.gov Identifier: NCT03030508.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Milk and Egg Are Risk Factors for Adverse Effects of Capecitabine-Based Chemotherapy in Chinese Colorectal Cancer Patients

Lin

Chen

et al. 2022

Integr Cancer Ther

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“…Last but not least, screening miRNAs from normal tissues other than tumors may provide more informative clues. Accumulating evidence suggests that the efficacy and safety of chemotherapy are not solely dependent on drug metabolism but also on the overall physiological functions [44,[48][49][50][51][52][53]. Individual differences in cell maintenance, proliferation, and immune function also influence the response to chemotherapy.…”

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confidence: 99%

A Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs

Sun

Chen

et al. 2022

Disease Markers

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Colorectal cancer (CRC) is becoming increasingly prevalent worldwide. Fluoropyrimidine drugs are the primary chemotherapy regimens in routine clinical practice of CRC. However, the survival rate of patients on fluoropyrimidine-based chemotherapy varies significantly among individuals. Biomarkers of fluoropyrimidine drugs’' efficacy are needed to implement personalized medicine. This review summarized fluoropyrimidine drug-related microRNA (miRNA) by affecting metabolic enzymes or showing the relevance of drug efficacy. We first outlined 42 miRNAs that may affect the metabolism of fluoropyrimidine drugs. Subsequently, we filtered another 41 miRNAs related to the efficacy of fluoropyrimidine drugs based on clinical trials. Bioinformatics analysis showed that most well-established miRNA biomarkers were significantly enriched in the cancer pathways instead of the fluoropyrimidine drug metabolism pathways. The result also suggests that the miRNAs screened from metastasis patients have a more critical role in cancer development than those from non-metastasis patients. There are five miRNAs shared between these two lists. The miR-21, miR-215, and miR-218 can suppress fluoropyrimidine drugs’' catabolism. The miR-326 and miR-328 can reduce the efflux of fluoropyrimidine drugs. These five miRNAs could jointly act by increasing intracellular levels of fluoropyrimidine drugs’' cytotoxic metabolites, leading to better chemotherapy responses. In conclusion, we demonstrated that the dynamic changes in the transcriptional regulation via miRNAs might play significant roles in the efficacy and toxicity of the fluoropyrimidine drug. The reported miRNA biomarkers would help evaluate the efficacy of fluoropyrimidine drug-based chemotherapy and improve the prognosis of colorectal cancer patients.

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Choline deficiency-related multi-omics characteristics are susceptible factors for chemotherapy-induced thrombocytopenia

Cited by 2 publications

References 62 publications

Milk and Egg Are Risk Factors for Adverse Effects of Capecitabine-Based Chemotherapy in Chinese Colorectal Cancer Patients

Milk and Egg Are Risk Factors for Adverse Effects of Capecitabine-Based Chemotherapy in Chinese Colorectal Cancer Patients

A Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs

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