Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk

İlçöl, Yeşim Özarda; Özbek, Resul; Hamurtekin, Emre; Ulus, İsmail H.

doi:10.1016/j.jnutbio.2005.01.011

Cited by 157 publications

(176 citation statements)

References 46 publications

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“…The reported correlation coefficients of the relationship between maternal and venous UC metabolites vary from 0.06 to 0.26 for choline, 0.11 to 0.46 for betaine, and 0.58 to 0.73 for DMG (15,(19)(20)(21)(22). Furthermore, there are consistent reports on choline concentrations in cord plasma that are several fold higher than in maternal plasma, both in humans (8,14,15,(20)(21)(22)(23) and animals (16). Similar results were obtained in the present study.…”

Section: Umbilical Choline and Birth Weightsupporting

confidence: 90%

“…Timing of maternal samples differed from 16 wk of GA to delivery. Maternal choline, betaine, and DMG concentrations described in the literature are comparable with our results (18)(19)(20)(21)(22).Several studies concerning umbilical choline concentrations have been performed (8,15,(20)(21)(22)(23). They are small (8,20,22,23), did not involve maternal and umbilical data (8), or did not evaluate the possible association between birth weight and choline concentrations (8,15,(21)(22)(23).…”

supporting

confidence: 82%

“…Several studies concerning umbilical choline concentrations have been performed (8,15,(20)(21)(22)(23). They are small (8,20,22,23), did not involve maternal and umbilical data (8), or did not evaluate the possible association between birth weight and choline concentrations (8,15,(21)(22)(23).…”

Section: Umbilical Choline and Birth Weightmentioning

confidence: 99%

“…They are small (8,20,22,23), did not involve maternal and umbilical data (8), or did not evaluate the possible association between birth weight and choline concentrations (8,15,(21)(22)(23). UC plasma choline concentrations have been described between ~25 and 40 µmol/l (8,14,15,20,22,23), The coefficients presented give the change in birth weight (grams) for the several variables.…”

Section: Umbilical Choline and Birth Weightmentioning

confidence: 99%

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Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight

et al. 2013

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Background: Low birth weight (LBW) is associated with increased morbidity and mortality for the newborn and risk of chronic disease in adulthood. Choline plays an essential role in the integrity of cell membranes, methylation reactions, and memory development. We examined whether choline, betaine, and dimethylglycine (DMG) concentrations were associated with LBW in Dutch women. Methods: Blood was sampled from umbilical cords (UCs) at delivery in singleton pregnancies (n = 1,126). Maternal blood was sampled at 30-34 wk of gestational age (GA) (n = 366). We calculated birth weights standardized for GA and defined LBW as standardized birth weight ≤2,500 g. results: Maternal concentrations were lower as compared with UC concentrations and were not associated with birth weight. UC choline and betaine were inversely associated with birth weight (β = −60 (−89, −31) and β = −65 (−94, −36), respectively), whereas UC DMG was positively associated with birth weight (β = 35 (6.1, 63)). Odds ratios for LBW were 4.12 (1.15, 14.78), 5.68 (1.24, 25.91), and 0.48 (0.09, 2.65) for the highest UC choline, betaine, and DMG quartiles, respectively, as compared with the lowest quartiles. conclusion: We observed an increased risk of LBW with increased umbilical choline and betaine in venous UC blood. These results might reflect a change in choline consumption or metabolism or a disturbed placental function. l ow birth weight (LBW) poses the newborn an increased risk of morbidity and mortality (1). LBW also relates to an increased risk of chronic disease in adulthood, e.g., hypertension, coronary heart disease, stroke, and diabetes (2), underlining the importance of revealing possible and moreover treatable risk factors for LBW.Choline is an essential nutrient and is involved in several metabolic processes including lipid metabolism, methylation reactions, and synthesis of acetylcholine. It also plays a role in the structural integrity and signaling functions of cell membranes, brain development, and neurotransmission (Figure 1) (3,4).Pregnancy places a heavy burden on maternal choline stores, and choline is critical for the rapidly growing fetus (5,6).In utero, the fetus lives in a high-choline environment because of a system actively transporting choline against a concentration gradient across the placenta to the fetus (7,8). Variation in maternal choline status could possibly influence fetal outcome through disturbances in cell membrane synthesis, increase in homocysteine concentrations, and/or perturbation of methylation reactions and changes in acetylcholine production. Choline also influences stem cell proliferation, apoptosis in the brain, and the developing hippocampus (memory center) in rodents (9). Maternal choline supplementation in rats during critical periods in pregnancy causes lifelong changes in brain structure (10). In addition, perinatal choline supplementation attenuates behavioral alterations associated with fetal or neonatal alcohol exposure in rats (11).Clinically, low maternal choline concentrations or intake rel...

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Section: Umbilical Choline and Birth Weightsupporting

confidence: 90%

supporting

confidence: 82%

Section: Umbilical Choline and Birth Weightmentioning

confidence: 99%

Section: Umbilical Choline and Birth Weightmentioning

confidence: 99%

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Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight

et al. 2013

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“…These findings indicate that the type of feeding during early infancy can influence the infant's choline metabolism, as well as the levels of other metabolites. This study agrees well with Ilcol et al (2005) study which showed the direct correlation between infant serum choline levels and their mother's BM choline content. Serum free choline levels were shown to decrease as phospholipid-bound choline increased over time.…”

Section: Impact Of Breastmilk On Infant Health Outcomessupporting

confidence: 92%

Breastmilk Metabolomics: Bridging the Gap between Maternal Nutrition and Infant Health Outcomes

Sumayao

Benigno

Jaen

et al. 2017

KIMIKA

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Breastmilk (BM) is the primary source of nutrition for the newborn infant and its first six months of life. Although the importance of BM in the proper growth and development of infants has previously been recognized in various research studies, it was not until various metabolites were probed in BM that researchers discovered the various beneficial effects of BM beyond its nutritive value. Metabolomics has emerged as a discipline which aims to comprehensively profile various metabolites in food and biological fluids. Although still in its incipient stages, BM metabolomics has provided invaluable insights into the chemical interaction between mother and infant. NMR-and MS-based techniques have made it possible to explore the metabolome of BM and link it to various aspects of maternal phenotype and nutrition and breastfed infant health outcomes. In addition, recent developments in analytical approaches for BM metabolite analysis and metabolomic data analysis have allowed researchers to increase the coverage of detected metabolites using multiple platforms and have supported its functional characterization which aids in investigation of the clinical and biological importance of metabolites. These advancements can potentially aid in the development of strategies to promote healthy feeding practices for infants or novel therapeutic and nutrition advances in pediatric research.

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Lipids in Infant Formula

Zou

Zhang²,

Pedersen

et al. 2020

Bailey's Industrial Oil and Fat Products

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Human milk (HM) provides the ideal nourishment for infant growth and cognitive development. The new advances in component and microstructure analyses of HM provide solid knowledge for developing better infant formulas to mimic HM to the largest extent possible. In this article, we reviewed the latest progress in the analysis and understanding of the physical structures, composition, and phospholipids and other minor components in HM lipids, as well as in its counterpart infant formula (IF) lipids. The similarities and differences of lipids between HM and IF suggest the gaps to be narrowed for improved IF development, as the theme of IF lipids studies, which are not only on fatty acid composition, but also on triacylglycerol (TAG) profiles and minor lipid species and level of supplements. The efforts and researches in searching alternative oils and fats and development of related chemical/enzymatic processes comprise a key focus of this article. The specifications to regulate IF market, marketing trend, and patenting status are also intensively discussed. Moreover, the risk substance controls of 3‐monochloro‐1,2‐propanediol (3‐MCPD esters) and glycidyl esters (GE) and the strategy to mitigate them during IF lipid process are also reviewed.

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Choline status in newborns, infants, children, breast-feeding women, breast-fed infants and human breast milk

Cited by 157 publications

References 46 publications

Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight

Umbilical choline and related methylamines betaine and dimethylglycine in relation to birth weight

Breastmilk Metabolomics: Bridging the Gap between Maternal Nutrition and Infant Health Outcomes

Lipids in Infant Formula

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