Cholinergic and glutamatergic activation reverses working memory failure by hippocampal histamine H1 receptor blockade in rats

Nakazato, Etsuko; Yamamoto, Tsuneyuki; Ohno, Minoru; Watanabe, Soichi

doi:10.1016/s0024-3205(00)00713-x

Cited by 32 publications

(20 citation statements)

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“…Nevertheless, one can reasonably conceive that these results also hold for both consolidation and reconsolidation. For instance, bilateral dorso-hippocampal infusions of NMDA receptor agonists attenuated the retrieval deficit of a radial-maze task induced by a systemic injection of an H 1 receptor antagonist, an effect that was exacerbated by an H 3 receptor agonist (Nakazato et al, 2000;Masuoka and Kamei, 2009;Masuoka et al, 2010). Conversely, bilateral ventral or dorsal hippocampal infusions of the H 3 receptor inverse agonist clobenpropit or histamine reduced radialmaze working memory deficits induced by systemic dizocilpine, and the effect of clobenpropit was reversed by an H 3 receptor agonist and an H 1 receptor antagonist (Huang et al, 2003(Huang et al, , 2004Xu et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Charlier

Tirelli

2011

Neuroscience

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Abstract-Albeit there is no doubt that histamine and its H 3 receptors participate in several aspects of learning and memory, such as memory consolidation, nothing is known about their potential involvement in memory reconsolidation. On the basis of previous reports of pro-cognitive effects of histamine H 3 receptor inverse agonists (which augment histamine release), we investigated to what extent the most representative of them, thioperamide, is able to facilitate reconsolidation of a contextually-conditioned fear memory in C57BL/6J mice. We also examined the effects of thioperamide on the stark disruptive effect that the non-competitive N-methyl-D-aspartate (NMDA) antagonist dizocilpine (MK-801) typically exerts on both reconsolidation and consolidation. Post-training systemic injections (i.p.) of thioperamide facilitated consolidation at 10 and 20 mg/kg and reversed amnesia induced by an i.p. injection of 0.12 mg/kg dizocilpine at 5, 10 and 20 mg/kg. Importantly, none of the five thioperamide doses (2.5, 5, 10, 20 and 30 mg/kg) given right after reactivation (reexposure to the context in which training took place 48 h earlier) affected reconsolidation, whereas all similarly given doses of dizocilpine (0.03, 0.06 and 0.12 mg/kg) disrupted it more or less equally. By contrast, thioperamide was able to unambiguously reverse the deficit in reconsolidation induced by 0.12 mg/kg dizocilpine at 10 and 20, but not 5 mg/kg. This is the first demonstration of an involvement of the interactive articulation between histamine and NMDA receptors in the mechanisms of memory reconsolidation, which seems to be indifferent to an increase of brain histamine per se. The results suggest a qualitatively different participation of histaminergic signalling in the mechanisms of reconsolidation and consolidation. The precise circuits within which these interactions take place are yet to be identified.

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Section: Discussionmentioning

confidence: 99%

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Charlier

Tirelli

2011

Neuroscience

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“…From these findings, Ohno and Watanabe (11) proposed that NMDA function upregulated by group I mGlu receptors in the hippocampus markedly contributed to working memory performance. Previous studies also indicated that the histamine H 1 receptor antagonist-induced memory deficit and decrease in hippocampal theta activity were prevented by intrahippocampal injection of NMDA-receptor agonists (8,9); therefore, it is reasonable to presume that intrahippocampal group I mGlu-receptor agonists can compensate for the decrease of NMDA receptor-mediated transmission induced by a histamine H 1 -receptor antagonist.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, Barnes maze performance and hippocampal CA1 longterm potentiation were impaired in histamine H 1 receptor-knockout mice (6). In addition, intrahippocampal injection of pyrilamine, a selective histamine H 1 -receptor antagonist, impaired performance in the radial maze and three-panel runway task (7,8).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, Nakazato et al (8) reported that an intrahippocampal injection of pyrilamine impaired working memory, and this pyrilamine-induced memory deficit was ameliorated by concurrent injection of an NMDA-receptor glycine binding-site partial agonist, D -cycloserine. In addition, our previous study indicated that the intrahippocampal injection of D -cycloserine; NMDA-receptor polyamine binding-site agonists, spermidine and spermine; and α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-receptor desensitization inhibitors, aniracetam and 1-(1,3-benzodioxol-5-ylcarbonyl) piperidine (1-BCP), ameliorated the working memory deficit induced by the intraperitoneal injection of pyrilamine (9); therefore, glutamatergic transmission mediated by hippocampal NMDA and AMPA receptors is involved in histamine H 1 receptor antagonist-induced memory deficit.…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative Effect of a Hippocampal Metabotropic Glutamate– Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats

2010

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Abstract. This study was performed to investigate the ameliorative effects of metabotropic glutamate (mGlu)-receptor agonists on histamine H 1 receptor antagonist-induced spatial memory deficit and the decrease in hippocampal theta activity in rats. Intraperitoneal injection of pyrilamine (35 mg/kg) resulted in impaired reference and working memory in the radial maze task and decreased hippocampal theta amplitude and power. The working memory deficit and decreased hippocampal theta power induced by pyrilamine were ameliorated by intrahippocampal injection of ( RS )-3,5-dihydroxyphenylglycine (DHPG) (1 and 10 μ g/side), a group I mGlu-receptor agonist; however, intrahippocampal injection of (2 R ,4 R )-4-aminopyrrolidine-2,4-dicarboxylate (APDC), a group II mGlu-receptor agonist, and L -(+)-2-amino-4-phosphonobutyric acid ( L -AP4), a group III mGlu-receptor agonist, showed no significant effect on the pyrilamine-induced memory deficit and decreased hippocampal theta activity. These results indicate that the activation of hippocampal group Ι mGlu receptors, but not group II and III mGlu receptors, improve the histamine H 1 receptor antagonist-induced working memory deficit and decreased hippocampal theta activity.

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“…Briefly, working memory refers to memory in which the information to be remembered changes in repeated trials, and thereby is trial dependent, whereas reference memory refers to memory for information that remains constant over repeated trials and is, therefore, trial independent [32] . The three-panel runway task, since it particularly allows distinction between working and reference memory, serves well as a method for the study of learning and memory functions in rats [33] .…”

Section: Discussionmentioning

confidence: 99%

Effects of <i>L</i>-Arginine on 7-Nitroindazole-Induced Reference and Working Memory Performance of Rats

et al. 2009

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Background/Aims: This study was performed in order to elucidate the effects of 7-nitroindazole (7-NI) and L-arginine on cognitive functions of rats in a three-panel runway task. Methods: 7-NI (2.5, 5, 10 mg/kg) and L-arginine (200 mg/kg) were injected intraperitoneally into male Wistar rats 30 min before the test. Results: 7-NI (5, 10 mg/kg) significantly increased the number of errors (pushes made on the 2 incorrect panels of the panel gate at 4 choice points) and prolonged the latency of reference memory in the three-panel runway task. The negative effects of 7-NI on reference memory was counteracted by L-arginine, a substrate for nitric oxide synthase. While having no effect on the number of working memory errors in working memory trials, 7-NI prolonged the latency from the 2nd to the 6th trial at the 5- and 10-mg/kg doses. Concurrent administration with L-arginine counteracted the 7-NI-induced prolongation of latency from the 2nd to the 6th trial. Conclusion: 7-NI impaired reference memory but not working memory in the three-panel runway test. Moreover, nitric oxide played an essential role in the development of reference memory and the negative effects of 7-NI on memory were counteracted by L-arginine.

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Cholinergic and glutamatergic activation reverses working memory failure by hippocampal histamine H1 receptor blockade in rats

Cited by 32 publications

References 0 publications

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Differential effects of histamine H3 receptor inverse agonist thioperamide, given alone or in combination with the N-methyl-d-aspartate receptor antagonist dizocilpine, on reconsolidation and consolidation of a contextual fear memory in mice

Ameliorative Effect of a Hippocampal Metabotropic Glutamate– Receptor Agonist on Histamine H1 Receptor Antagonist–Induced Memory Deficit in Rats

Effects of <i>L</i>-Arginine on 7-Nitroindazole-Induced Reference and Working Memory Performance of Rats

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