Cholinergic blockade effects on spatial integration versus cue discrimination performance.

Ellen, Paul; Taylor, Howard S.; Wages, Charlene

doi:10.1037/0735-7044.100.5.720

Cited by 17 publications

(8 citation statements)

References 18 publications

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“…Since the behavioural effects of atropine sulfate were demonstrated on a different spatial task than the Morris water maze (Morris, 1981), the present results extend the range of behavioural tasks that demonstrate the importance of central cholinergic mechanisms in reference memory and place navigation. The fact that previous studies (Sutherland et al, 1982 b;Ellen et al, 1986;Hagan et al, 1986) have determined that the spatial performance of rats treated with atropine methylnitrate, a peripheral cholinergic blocker, was as good as that of normal control rats suggests that blockade of cholinergic synapses in the central nervous system produces the spatial impairment. It is conceivable that central cholinergic blockade affects choice accuracy and escape latency in separate ways.…”

Section: Discussionmentioning

confidence: 99%

“…Large doses of atropine sulfate (50-100 mg/kg, ip) have typically been used to block central cholinergic function and impair spatial performance (Whishaw, 1985;Hagan et al, 1986;Ellen et al, 1986;Sutherland et al, 1982 b;Whishaw and Tomie, 1987). This dose range has typically been selected because it alters forebrain acetylcholine release (Dudar etal., 1979), forebrain electroencephalographic activity (Vanderwolf, 1975) and produces virtually complete occupation of muscarinic binding sites in the rat brain (Yamamura, Kuhar and Snyder, 1974).…”

Section: Introductionmentioning

confidence: 99%

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Low doses of atropine sulfate impair retention of a well-learned spatial task

Rauch

Welch

Gallego

1989

J Neural Transm Gen Sect

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Retention of a well-learned spatial task was assessed in rats 10 minutes prior to, and 10, 20, 30, 40, and 50 minutes after treatment with 3, 10 or 30 mg/kg, iv, atropine sulfate or the equivalent volume of saline, iv. There was a variable dose effect for escape latency and choice accuracy measures of spatial retention. A relatively large dose of atropine sulfate (30 mg/kg, iv) significantly impaired choice accuracy and escape latency compared with the control group. Moreover, impairment in choice accuracy was observed with smaller doses of atropine sulfate (3, 10 mg/kg, iv) than have previously been shown to disrupt spatial retention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low doses of atropine sulfate impair retention of a well-learned spatial task

Rauch

Welch

Gallego

1989

J Neural Transm Gen Sect

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“…Treatments with cholinergic antagonists (such as scopolamine or atropine) were indeed found to induce similar deficits on spatial memory (e.g., Buresova et al, 1986;Ellen et al, 1986) and on response to a spatial change in an object exploration task (Buhot et al, 1989b;Save et al, 1992b) as hippocampal lesions.…”

mentioning

confidence: 94%

“…A wealth of evidence can be found in the literature suggesting that hippocampal functions receive a major input of the septo-hippocampal cholinergic pathway (e.g., Brito et al, 1983;Kelsey and Vargas, 1993;Marighetto et al, 1993). Treatments with cholinergic antagonists (such as scopolamine or atropine) were indeed found to induce similar deficits on spatial memory (e.g., Buresova et al, 1986;Ellen et al, 1986) and on response to a spatial change in an object exploration task (Buhot et al, 1989b;Save et al, 1992b) as hippocampal lesions.…”

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confidence: 99%

Changes in exploratory activity following stimulation of hippocampal 5‐HT1A and 5‐HT1B receptors in the rat

Buhot

Naïli

1995

Hippocampus

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The object exploration task allows the measure of changes in locomotor and exploratory activities, habituation, and reaction to a spatial change and to novelty. The effects of intrahippocampal (dorsal CA1 field) microinjections of serotonin 1 receptor (5-HT1) agonists on these behavioral components were evaluated in the rat. 8-Hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT, 5 micrograms/microliters) was used as a 5-HT1A agonist, 3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one (CP 93,129,16 micrograms/microliters) as a 5-HT1B agonist, and scopolamine (10 micrograms/microliters) as a muscarinic cholinergic antagonist. Scopolamine induced a long-lasting increase in locomotor activity and a lack of reaction to spatial change; both these results are in agreement with the known crucial influence of the septo-hippocampal cholinergic system in hippocampal functioning. Stimulation of 5-HT1A and 5-HT1B receptors induced a decrease in object exploration and habituation without affecting the retrieval of spatial information. But stimulation of hippocampal 5-HT1B receptors induced a selective change in the animal's emotional state, i.e., an initial decrease in locomotor activity and a neophobic reaction in response to a new object; such effects did not occur following stimulation of 5HT1A receptors. These results have to be considered in the light of the anxiogenic property of 5-HT1B agonists. On the whole, they support the hypothesis of the involvement of the serotonergic system, via 5HT1A and 5-HT1B receptors, in the modulation of hippocampal functions.

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“…Central blockade of cholinergic synapses produces an inability to use spatial mapping strategies during the acquisition of spatial tasks (Sutherland et al, 1982;Hagan et al, 1986;Stevens, 1981;Whishaw, 1985;Ellen et al, 1986). However, studies of central cholinergic blockade on the retention of overtrained spatial tasks produce conflicting results (Buresova et al, 1986;Costall et al, 1988;Harley, 1979;Whishaw, 1985;Levy et al, 1983;Buresova and Bures, 1982;Eckerman et al, 1980;Hagan et al, 1986;Rauch et al, 1988Rauch et al, , 1989.…”

Section: Introductionmentioning

confidence: 99%

Atropine sulfate impairs selective parameters of performance in the Morris water maze

1990

J Neural Transm Gen Sect

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Twelve rats were trained to learn the location of a spatially fixed platform hidden in a Morris water maze. Asymptotic performance was achieved over six training days (10 trials/day). Then retention of the spatial task was assessed 30 min after treatment with 5, 25, 50, 75, or 100 mg/kg, ip, atropine sulfate or the equivalent volume of saline. There was a significant drug effect on escape latency, swim distance, swim speed and swim path measures of spatial performance. There was no significant drug effect on heading error; atropinized animals initially headed toward the escape platform over the first 12 cm of their swim path. However, treatment with atropine sulfate significantly disrupted the usual, direct swim path used to reach the hidden escape platform. Atropinized animals frequently swam a spiraled or looping pattern to locate the platform. We suggest that cholinergic blockade may significantly disrupt the processing of visual cues which rats use in place navigation tasks.

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Cholinergic blockade effects on spatial integration versus cue discrimination performance.

Cited by 17 publications

References 18 publications

Low doses of atropine sulfate impair retention of a well-learned spatial task

Low doses of atropine sulfate impair retention of a well-learned spatial task

Changes in exploratory activity following stimulation of hippocampal 5‐HT1A and 5‐HT1B receptors in the rat

Atropine sulfate impairs selective parameters of performance in the Morris water maze

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