Cholinergic deficits in aged rat spinal cord: restoration by GM1 ganglioside

Vogelsberg, Vanessa; Fong, Tamara G.; Neff, Norton H.; Hadjiconstantinou, Maria

doi:10.1016/s0006-8993(97)00326-0

Cited by 14 publications

(7 citation statements)

References 57 publications

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“…The improved neurochemical indices and performance in place navigation are not lost if GM1 treatment is discontinued and animals tested 15 days later (Fong et a!., 1995a(Fong et a!., , 1997a. In addition, GM1 restores the decreased HAChT and ChAT activities, as well as the reduced number of hemicholinium-3 binding sites in the aged spinal cord (Vogelsberg et a!., 1997). In agreement with the above studies, Silva et a!.…”

Section: Aged Cholinergic Neuronsmentioning

confidence: 58%

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

Hadjiconstantinou

Neff

1998

Journal of Neurochemistry

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There is now substantial evidence that GM1 ganglioside is effective in partially correcting the consequences of neuroinjury in a number of in vivo and in vitro model systems. Although the molecular mechanism(s) and the substrates for the neurotrophic activity of the gangliosides are not fully understood, the published experimental work suggests that GM1 has antineurotoxic, neuroprotective, and neurorestorative effects on various central neurotransmitter systems. This review focuses attention on studies reporting that GM1 restores neuronal integrity and function in the brain of lesioned young as well as aged animals. Critical analysis of these studies can provide guidance for future ganglioside research and may point to novel approaches for treating neuroinjury and a variety of degenerative conditions, including aging.

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Section: Aged Cholinergic Neuronsmentioning

confidence: 58%

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

Hadjiconstantinou

Neff

1998

Journal of Neurochemistry

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“…This analysis suggests that the compromise of the cholinergic activity is not generalized, but is instead related to specific populations of cholinergic neurons. Finally, we have measured a significant, and apparently precocious, decrease of ChAT activity in the spinal cord for which only few data were available previously (Vogelsberg et al, 1997). The decrease of cholinergic activity in the spinal cord correlates with the progressive loss of cholinergic motor neurons taking place with aging (Cruz-Sanchez et al, 1998).…”

Section: Discussionmentioning

confidence: 98%

Topography of neurochemical alterations in the CNS of aged rats

Virgili

Monti²,

Polazzi³

et al. 2001

Intl J of Devlp Neuroscience

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We have performed a general survey study on alterations of neurotransmitter-related and glia-related neurochemical markers in various regions of the CNS of aged (30-month-old) as compared to adult (4-month-old) rats. We have found significant decreases in the level of neurochemical parameters related to the cholinergic and GABAergic systems in several regions of the CNS of aged rats. Only few of the alterations present at the age of 30 months, were present in a group of rat of intermediate age (20 months) included in the present study. Less widespread alterations were found concerning the glutamatergic neurotransmission system. Neurochemical markers related to glial cells (astrocytes and oligodendrocytes) showed a remarkable stability in aged rats as compared to neurotransmitter-related markers. Considering the various CNS areas examined in the present study, the spinal cord of the aged rats was the region showing the most profound alterations of neurochemical parameters, as compared to the various brain areas of the same rats. The present results suggest that moderate and region-specific alterations of neurotransmitter-related parameters occur during normal aging and that glia-related markers are fundamentally stable in the absence of specific pathologies.

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“…ChAT, Ch uptake, and hemicholinium‐3 (HC‐3) binding to the choline carrier were reduced in the aged spinal cord. 18 Treatment with GM1 induced a partial recovery of the presynaptic cholinergic decrements in the aged spinal cord (Table 3).…”

Section: Gm1 Improves Cholinergic Function In the Aged Brainmentioning

confidence: 97%

GM1 and the Aged Brain^a

Hadjiconstantinou

Neff

1998

Annals of the New York Academy of Sciences

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Aging is associated with the loss of brain neurotransmitter function, which apparently is the substrate for an adverse constellation of age-associated symptoms. In particular, cholinergic deficits have been associated with cognitive impairment in aging. Systemic administration of GM1 ganglioside, 30 mg/kg, i.p., for 30 days, enhances the cholinergic neurochemical presynaptic markers, choline acetyltransferase, choline uptake, and acetylcholine, in the brain and spinal cord of aged 22-24-month-old Sprague-Dawley rats. In addition to correcting cholinergic neurochemistry, it improves spatial learning and memory impairment, and restores the number and the size of the cholinergic neurons in the basal forebrain and striatum. The induced neuronal recovery by GM1 is long-lasting.

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Cholinergic deficits in aged rat spinal cord: restoration by GM1 ganglioside

Cited by 14 publications

References 57 publications

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

Topography of neurochemical alterations in the CNS of aged rats

GM1 and the Aged Brain^a

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Cholinergic deficits in aged rat spinal cord: restoration by GM1 ganglioside

Cited by 14 publications

References 57 publications

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

GM1 Ganglioside: In Vivo and In Vitro Trophic Actions on Central Neurotransmitter Systems

Topography of neurochemical alterations in the CNS of aged rats

GM1 and the Aged Braina

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GM1 and the Aged Brain^a