2023
DOI: 10.1096/fj.202202108r
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Cholinergic drugs reduce metabolic inflammation and diabetic myocardial injury by regulating the gut bacterial component lipopolysaccharide‐induced ERK/Egr‐1 pathway

Abstract: Autonomic imbalance and metabolic inflammation are important pathological processes in diabetic cardiomyopathy. Gut microbiota dysbiosis and increased levels of bacterial component lipopolysaccharide (LPS) are associated with diabetic myocardial injury, but the mechanism by which gut microbes affect metabolic inflammation and cardiac injury remains unclear. We determined whether pyridostigmine (PYR), which inhibits cholinesterase to improve vagal activity, could regulate the disordered gut microbiota and atten… Show more

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Cited by 8 publications
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“…This serves the purpose of eliminating debris, which is essential for repair and recovery. Overactivation of microglia, however, leads to neuroinflammatory and neurological conditions, including MDD [ 143 , 144 , 145 , 146 ].…”
Section: Glial Cellsmentioning
confidence: 99%
“…This serves the purpose of eliminating debris, which is essential for repair and recovery. Overactivation of microglia, however, leads to neuroinflammatory and neurological conditions, including MDD [ 143 , 144 , 145 , 146 ].…”
Section: Glial Cellsmentioning
confidence: 99%