Cholinergic effects on fear conditioning II: nicotinic and muscarinic modulations of atropine-induced disruption of the degraded contingency effect

Carnicella, Sébastien; Pain, Laure; Oberling, Philippe

doi:10.1007/s00213-004-2101-6

Cited by 10 publications

(5 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, our failure to detect changes in performance on saline injection days between atropine exposures suggest that such effects were small at best, but such effects cannot be rule out. However, it is not unusual to observe an inverted U-shaped function of learning or performance effects with muscarinic anticholinergic drugs such as atropine and scopolamine (e.g., Carnicella et al, 2005a, 2005b; Rasmussen & Fink-Jensen, 2000; Stewart & Blain, 1975), and such effects have been attributed to drug effects on cortical arousal measured by EEG and concomitant cognitive arousal that align with the Yerkes-Dodson law (Graef, Schoknecht, Sabri, & Hegerl, 2011). …”

Section: Discussionmentioning

confidence: 99%

“…Cholinergic systems play a complex role in Pavlovian conditioning (e.g., Carnicella, Pain, & Oberling, 2005a, 2005b), instrumental conditioning (Whitehouse, 1964), response timing (Meck, 1996; Meck & Church, 1987), and multiple types of attention (e.g., Maddux et al, 2007; Sarter, 2007). Muscarinic anticholinergic drugs such as the muscarinic acetylcholine receptor antagonists, atropine and scopolamine, have been shown to produce impairments in rats’ retention performance on tasks such as single alternation (Heise, Hrabrich, Lilie, & Martin, 1975), go/no-go discrimination (Milar, Halgren, & Heise, 1978; Viscardi & Heise, 1986), delayed matching- and non-matching-to-position (Roitblat, Harley, & Helweg, 1989; Spencer, Pontecorvo, & Heise, 1985), and radial maze working memory (Beatty & Bierley, 1985; Okaichi & Jarrard, 1982).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Central cholinergic involvement in sequential behavior: Impairments of performance by atropine in a serial multiple choice task for rats

Fountain

Rowan

Wollan

2013

Neurobiology of Learning and Memory

View full text Add to dashboard Cite

Two experiments examined whether muscarinic cholinergic systems play a role in rats’ ability to perform well-learned highly-structured serial response patterns, particularly focusing on rats’ performance on pattern elements learned by encoding rules versus by acquisition of stimulus-response (S-R) associations. Rats performed serial patterns of responses in a serial multiple choice task in an 8-lever circular array for hypothalamic brain-stimulation reward. Two experiments examined the effects of atropine, a centrally-acting muscarinic cholinergic receptor antagonist, on rats’ ability to perform pattern elements where responses were controlled by rules versus elements, such as rule-inconsistent “violation elements” and elements following “phrasing cues,” where responses were controlled by associative cues. In Experiment 1, 3-element chunks of both patterns were signaled by pauses that served as phrasing cues before chunk-boundary elements, but one pattern also included a violation element that was inconsistent with pattern structure. Once rats reached a high criterion of performance, the drug challenge was intraperitoneal injection of a single dose of 50 mg/kg atropine sulfate. Atropine impaired performance on elements learned by S-R learning, namely, chunk-boundary elements and the violation element, but had no effect on performance of rule-based within-chunk elements. In Experiment 2, patterns were phrased and unphrased perfect patterns (i.e., without violation elements). To control for peripheral effects of atropine, rats were treated with a series of doses of either centrally-acting atropine or peripherally-acting atropine methyl nitrate (AMN), which does not cross the blood-brain barrier. Once rats reached a high criterion, the drug challenges were on alternate days in the order 50, 25, and 100 mg/kg of either atropine sulfate or AMN. Atropine, but not AMN, impaired performance in the phrased perfect pattern for pattern elements where S-R associations were important for performance, namely, chunk-boundary elements. However, in the structurally more ambiguous unphrased perfect pattern where rats had fewer cues and presumably relied more on S-R associations throughout, atropine impaired performance on all pattern elements. Thus, intact muscarinic cholinergic systems were shown to be necessary for discriminative control previously established by S-R learning, but were not necessary for rule-based serial pattern performance.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Central cholinergic involvement in sequential behavior: Impairments of performance by atropine in a serial multiple choice task for rats

Fountain

Rowan

Wollan

2013

Neurobiology of Learning and Memory

View full text Add to dashboard Cite

show abstract

“…This process could result from an interlink between the cholinergic pathway and amyloidogenesis. 35,37 Furthermore, the reduced release of acetylcholine inflicted by Aβ and vice versa was observed. 38 4.3.…”

Section: Chemically Induced Intraperitoneal Administrationmentioning

confidence: 92%

“…It also blocks the nicotinic one up to a minor extent. , Atropine in a dose of 5 mg/kg intraperitoneally (ip) for 21 days generated amyloid plaques, a pathological hallmark of AD. This process could result from an interlink between the cholinergic pathway and amyloidogenesis. , Furthermore, the reduced release of acetylcholine inflicted by Aβ and vice versa was observed …”

Section: Chemically Induced Intraperitoneal Administrationmentioning

confidence: 99%

See 1 more Smart Citation

Preclinical Models for Alzheimer’s Disease: Past, Present, and Future Approaches

et al. 2022

View full text Add to dashboard Cite

A robust preclinical disease model is a primary requirement to understand the underlying mechanisms, signaling pathways, and drug screening for human diseases. Although various preclinical models are available for several diseases, clinical models for Alzheimer’s disease (AD) remain underdeveloped and inaccurate. The pathophysiology of AD mainly includes the presence of amyloid plaques and neurofibrillary tangles (NFT). Furthermore, neuroinflammation and free radical generation also contribute to AD. Currently, there is a wide gap in scientific approaches to preventing AD progression. Most of the available drugs are limited to symptomatic relief and improve deteriorating cognitive functions. To mimic the pathogenesis of human AD, animal models like 3XTg-AD and 5XFAD are the primarily used mice models in AD therapeutics. Animal models for AD include intracerebroventricular-streptozotocin (ICV-STZ), amyloid beta-induced, colchicine-induced, etc., focusing on parameters such as cognitive decline and dementia. Unfortunately, the translational rate of the potential drug candidates in clinical trials is poor due to limitations in imitating human AD pathology in animal models. Therefore, the available preclinical models possess a gap in AD modeling. This paper presents an outline that critically assesses the applicability and limitations of the current approaches in disease modeling for AD. Also, we attempted to provide key suggestions for the best-fit model to evaluate potential therapies, which might improve therapy translation from preclinical studies to patients with AD.

show abstract

The role of the cholinergic system in the signal attenuation rat model of obsessive-compulsive disorder

Yankelevitch-Yahav

Joel

2013

Psychopharmacology

View full text Add to dashboard Cite

show abstract

Cholinergic effects on fear conditioning II: nicotinic and muscarinic modulations of atropine-induced disruption of the degraded contingency effect

Cited by 10 publications

References 58 publications

Central cholinergic involvement in sequential behavior: Impairments of performance by atropine in a serial multiple choice task for rats

Central cholinergic involvement in sequential behavior: Impairments of performance by atropine in a serial multiple choice task for rats

Preclinical Models for Alzheimer’s Disease: Past, Present, and Future Approaches

The role of the cholinergic system in the signal attenuation rat model of obsessive-compulsive disorder

Contact Info

Product

Resources

About