Cholinergic mechanism involved in the nociceptive modulation of dentate gyrus

Jiao, Runsheng; Yang, Chen; Zhang, Ying; Xu, Man-Ying; Yang, Xiaofang

doi:10.1016/j.bbrc.2008.12.184

Cited by 19 publications

(10 citation statements)

References 27 publications

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“…The electric activities of PENs and PINs returned to normal level at 8 and 10 min after the noxious stimuli, respectively. Xiao et al [7], Yang et al [8], Li et al [9], and Jiao et al [32] focused on electric activities of pain-related neurons in the hippocampus after noxious stimuli for many years. In the hippocampal CA1 and CA3 area and dentate gyrus, cholinergic neurons and muscarinic receptors have effects on the electric activities of PENs and PINs, so that they are involved in pain modulation [7–9, 32].…”

Section: Discussionmentioning

confidence: 99%

“…Xiao et al [7], Yang et al [8], Li et al [9], and Jiao et al [32] focused on electric activities of pain-related neurons in the hippocampus after noxious stimuli for many years. In the hippocampal CA1 and CA3 area and dentate gyrus, cholinergic neurons and muscarinic receptors have effects on the electric activities of PENs and PINs, so that they are involved in pain modulation [7–9, 32]. Glutamate and its receptors, noradrenaline (NE), phentolamine, and alpha-adrenoceptors also have effects on pain modulation by regulating electric activities of PENs and PINs in the hippocampal CA3 region [33, 34].…”

Section: Discussionmentioning

confidence: 99%

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Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats

Wang

Chen

et al. 2016

Neural Plasticity

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To study the effects of acupuncture analgesia on the hippocampus, we observed the effects of electroacupuncture (EA) and mitogen-activated protein kinase (MEK) inhibitor on pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the hippocampal area CA1 of sham or chronic constrictive injury (CCI) rats. The animals were randomly divided into a control, a CCI, and a U0126 (MEK1/2 inhibitor) group. In all experiments, we briefly (10-second duration) stimulated the sciatic nerve electrically and recorded the firing rates of PENs and PINs. The results showed that in both sham and CCI rats brief sciatic nerve stimulation significantly increased the electrical activity of PENs and markedly decreased the electrical activity of PINs. These effects were significantly greater in CCI rats compared to sham rats. EA treatment reduced the effects of the noxious stimulus on PENs and PINs in both sham and CCI rats. The effects of EA treatment could be inhibited by U0126 in sham-operated rats. The results suggest that EA reduces effects of acute sciatic nerve stimulation on PENs and PINs in the CA1 region of the hippocampus of both sham and CCI rats and that the ERK (extracellular regulated kinase) signaling pathway is involved in the modulation of EA analgesia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats

Wang

Chen

et al. 2016

Neural Plasticity

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“…While the exact mechanism of sucrose is unknown, several possible pathways have been proposed including opioid agonistic activity, [14], stimulating the release of dopamine [15,16] and acetylcholine [17]. Sucrose has been shown to decrease crying, grimacing, heart rate, vagal response, and unidimensional or multidimensional pain scores.…”

Section: Introductionmentioning

confidence: 99%

Reducing pain from heel lances in neonates following education on oral sucrose

Shen

El-Chaar

2015

Int J Clin Pharm

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“…A number of neurotransmitters and neuromodulators have been implicated in the hippocampal pathways involved in pain and analgesia, such as those of the muscarinic cholinergic system (Jiao et al 2009). At the same time, glutamatergic and serotonergic agents, when administered through intrahippocampal and intradentate gyrus routes, induce antinociception in rats (McKenna & Melzack, 2001;Soleimannejad et al, 2006Soleimannejad et al, , 2007.…”

Section: Discussionmentioning

confidence: 99%

Neuroanatomical and neuropharmacological approaches to postictal antinociception‐related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors

Freitas¹,

Bolognesi

Twardowschy

et al. 2013

Brain and Behavior

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Several studies have suggested the involvement of the hippocampus in the elaboration of epilepsy. There is evidence that suggests the hippocampus plays an important role in the affective and motivational components of nociceptive perception. However, the exact nature of this involvement remains unclear. Therefore, the aim of this study was to determine the role of muscarinic and nicotinic cholinergic receptors in the dorsal hippocampus (dH) in the organization of postictal analgesia. In a neuroanatomical study, afferent connections were found from the somatosensory cortex, the medial septal area, the lateral septal area, the diagonal band of Broca, and the dentate gyrus to the dH; all these areas have been suggested to modulate convulsive activity. Outputs to the dH were also identified from the linear raphe nucleus, the median raphe nucleus (MdRN), the dorsal raphe nucleus, and the locus coeruleus. All these structures comprise the endogenous pain modulatory system and may be involved either in postictal pronociception or antinociception that is commonly reported by epileptic patients. dH-pretreatment with cobalt chloride (1.0 mmol/L CoCl2/0.2 μL) to transiently inhibit local synapses decreased postictal analgesia 10 min after the end of seizures. Pretreatment of the dH with either atropine or mecamylamine (1.0 μg/0.2 μL) attenuated the postictal antinociception 30 min after seizures, while the higher dose (5.0 μg/0.2 μL) decreased postictal analgesia immediately after the end of seizures. These findings suggest that the dH exerts a critical role in the organization of postictal analgesia and that muscarinic and nicotinic cholinergic receptor-mediated mechanisms in the dH are involved in the elaboration of antinociceptive processes induced by generalized tonic-clonic seizures.

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Cholinergic mechanism involved in the nociceptive modulation of dentate gyrus

Cited by 19 publications

References 27 publications

Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats

Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats

Reducing pain from heel lances in neonates following education on oral sucrose

Neuroanatomical and neuropharmacological approaches to postictal antinociception‐related prosencephalic neurons: the role of muscarinic and nicotinic cholinergic receptors

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