Cholinergic Mechanisms, Adaptive Brain Processes and Psychopathology

Neurobiology of Acetylcholine

“…Karczmar and Richardson, 1985;Karczmar 1986). Speculatively, these data are consistent with the concept that cholinergic activity may be beneficial in schizophrenia (Singh, 1985) as stereotypy and catalepsy which examplify animal schizoid behavior (Karczmar, 1986d) benefit from cholinergic activation and are linked with deficits in cortico-striatal pathways that may be also implicated in schizophrenia (Singh, o.c. ).…”

“…Apparently, neither hypoxia nor electrolyte imbalances preceded these convulsions. Furthermore, tissue p02 in the brain did not decrease during the development of seizures induced by GD (100)(101)(102)(103)(104)(105)(106)(107)(108)(109)(110)s.c. ) in the freely-moving rat Lynch et al, 1985), indicating that tissue hypoxia is not involved in the development of nerve agent-induced seizures.…”