Cholinergic- rather than adrenergic-induced sweating play a role in developing and developed rat eccrine sweat glands

Zhang, Lei; Zhang, Xiang; Du, Lijie; Zhang, Cuiping; Li, Haihong

doi:10.1538/expanim.20-0144

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…SwGs are innervated by the sympathetic nervous system, mainly cholinergic fibers and a few are adrenergic fibers, which regulate the secretion of sweat [ [70] , [71] , [72] ]. Therefore, the ingrowth of the nerves to restore the innervation of the SwGs after an injury is of great value for the regeneration of functional SwGs.…”

Section: Swg Regeneration In Functional Wound Healingmentioning

confidence: 99%

Bioactive materials for in vivo sweat gland regeneration

Yang

Xiong

et al. 2024

Bioactive Materials

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Section: Swg Regeneration In Functional Wound Healingmentioning

confidence: 99%

Bioactive materials for in vivo sweat gland regeneration

Yang

Xiong

et al. 2024

Bioactive Materials

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“…1E ) and in the nasal region in pigs, and they regulate body temperature by direct secretion of water and salts from the epidermis 8 . In humans, sweat is produced to regulate body temperature; in rats and mice, it increases friction and strengthens grip 43 . These are merocrine glands composed of a long coiled secretory tubule and a connecting long excretory duct that ends in the epidermis separate from the hair follicle.…”

Section: Cutaneous Adnexamentioning

confidence: 99%

Morphological characteristics and notes of the skin in preclinical toxicity assessment

Moroki

2023

J Toxicol Pathol

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In this review, the histological structures of the skin are summarized for fundamental knowledge for toxicological assessment. The skin is composed of epidermis, dermis, subcutaneous tissue, and associated adnexa. In the epidermis, keratinocytes comprise four layers, and three other cell types, besides keratinocytes, play various roles. Epidermal thickness varies with species and body site. In addition, it can be affected by tissue preparation procedures, which can render toxicity assessments difficult. Bulge stem cells are the origin of sebaceous glands, epidermal basal layer, and hair follicle formation, and they play an important role in the maintenance of the basic structure of the skin. Stem cells and appendages formed from stem cells sometimes become toxic targets, and it is useful to study the origins of the hair follicle/hair cycle to interpret their toxicity. Irritant contact dermatitis and allergic contact dermatitis are the main adverse reactions in topical application studies. The mechanism involves direct chemical irritation of the skin, and histologically, epidermal necrosis and accompanying inflammatory cell infiltration. In allergic contact dermatitis, an inflammatory reaction and intercellular or intracellular edema, histologically represented by lymphocytic infiltration of the epidermis and dermis, are observed. Regional and species differences exist in the dermal absorption of compounds, and differences in the thickness of the stratum corneum substantially contribute to these differences. Learning the basic structures, functions, and possible artifacts will contribute to the evaluation of skin toxicity by topical and systemic applications.

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“…Accordingly, the initial focus of this section is the evaluation of research that has measured the concentration of molecules that are associated with these physiological systems, or related processes, in response to HA. Given the notable thermoregulatory differences between species [ 225 ], we generally constrain our review to literature examining changes in the concentration of relevant molecules in the biological samples of humans undertaking HA, and the consideration of candidate biomarkers where there is a biologically plausible rationale for their measurement. We subsequently extend the scope of our review to encompass research that has examined changes in inflammatory biomarkers with HA, and the measurement of putative heat adaptation biomarkers in other biological mediums, including the measurement of intracellular heat shock proteins, as well as use of sweat biomarkers.…”

Section: Candidate Biomarkersmentioning

confidence: 99%

Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review

Corbett,

Young,

Tipton

et al. 2023

J Physiol Sci

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Heat acclimation/acclimatisation (HA) mitigates heat-related decrements in physical capacity and heat-illness risk and is a widely advocated countermeasure for individuals operating in hot environments. The efficacy of HA is typically quantified by assessing the thermo-physiological responses to a standard heat acclimation state test (i.e. physiological biomarkers), but this can be logistically challenging, time consuming, and expensive. A valid molecular biomarker of HA would enable evaluation of the heat-adapted state through the sampling and assessment of a biological medium. This narrative review examines candidate molecular biomarkers of HA, highlighting the poor sensitivity and specificity of these candidates and identifying the current lack of a single ‘standout’ biomarker. It concludes by considering the potential of multivariable approaches that provide information about a range of physiological systems, identifying a number of challenges that must be overcome to develop a valid molecular biomarker of the heat-adapted state, and highlighting future research opportunities.

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Cholinergic- rather than adrenergic-induced sweating play a role in developing and developed rat eccrine sweat glands

Cited by 5 publications

References 28 publications

Bioactive materials for in vivo sweat gland regeneration

Bioactive materials for in vivo sweat gland regeneration

Morphological characteristics and notes of the skin in preclinical toxicity assessment

Molecular biomarkers for assessing the heat-adapted phenotype: a narrative scoping review

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