The Human Brain Circulation 1994
DOI: 10.1007/978-1-4612-0303-2_9
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Cholinergic Receptors in Human Brain Arteries and Microvessels

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Cited by 3 publications
(2 citation statements)
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“…In agreement with this, 5-HTm~ mRNA had previously been found in bovine and human cerebral arteries [19]. 5-HT2A receptor mRNA was shown to be expressed in rat aortic smooth muscle cells [20] and 5-HT 7 mRNA in human coronary artery [21].…”
Section: Discussionsupporting
confidence: 73%
“…In agreement with this, 5-HTm~ mRNA had previously been found in bovine and human cerebral arteries [19]. 5-HT2A receptor mRNA was shown to be expressed in rat aortic smooth muscle cells [20] and 5-HT 7 mRNA in human coronary artery [21].…”
Section: Discussionsupporting
confidence: 73%
“…Such a hypothesis is further supported by the potent coupling of the M5 mAChR subtype to NO synthesis and release (Wang et al, 1994) and its shared pharmacological similarities to the M3 mAChR, a subtype previously suggested to mediate the endothelium-dependent dilation of large cerebral (Dauphin and Hamel, 1990) and small pial (Shimizu et al, 1993) arteries. These characteristics, together with the ubiquitous presence of M5 mAChR in peripheral (Phillips et al, 1997), cerebral, and cerebromicrovascular tissues, have already led to the suggestion for its role in the ACh-mediated dilation (Hamel et al, 1994; Linville and Hamel, 1995; Elhusseiny et al, 1999; Phillips et al, 1997). The availability of a selective agonist or antagonist at this site will be necessary to unequivocally confirm this suggestion.…”
Section: Discussionmentioning
confidence: 99%