Cholinergic sensory inputs to command neurons in edible snail

Palikhova, T. A.; Abramova, M. S.; Pivovarov, A. S.

doi:10.1007/s10517-006-0345-3

Cited by 8 publications

(7 citation statements)

References 5 publications

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“…For example, ciliated cholinergic neurons in Drosophila are involved in an escaping jump behavior 25 . Furthermore, acetylcholine is the first neurotransmitter in the avoidance behavior in crickets 26 , the escape behavior in crayfish 27 and a defensive behavior in edible snail 28 . A common feature of these behaviors is that they require prompt response to the environment as a matter of life and death.…”

Section: Discussionmentioning

confidence: 99%

Nictation, a dispersal behavior of the nematode Caenorhabditis elegans, is regulated by IL2 neurons

et al. 2011

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Many nematodes show a stage-specific behavior called nictation in which a worm stands on its tail and waves its head in three dimensions. Here we show that nictation is a dispersal behavior regulated by a specific set of neurons, the IL2 cells, in C. elegans. We established assays for nictation and showed that cholinergic transmission was required for nictation. Cell type-specific rescue experiments and genetic ablation experiments revealed that the IL2 ciliated head neurons were essential for nictation. Intact cilia in IL2 neurons, but not in other ciliated head neurons, were essential, as the restoration of the corresponding wild-type gene activity in IL2 neurons alone in cilia-defective mutants was sufficient to restore nictation. Optogenetic activation of IL2 neurons induced nictation, suggesting that signals from IL2 neurons are sufficient for nictation. Finally, we demonstrated that nictation is required for transmission of C. elegans to a new niche using flies as artificial carriers, suggesting a role of nictation as a dispersal and survival strategy under harsh conditions.

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Section: Discussionmentioning

confidence: 99%

Nictation, a dispersal behavior of the nematode Caenorhabditis elegans, is regulated by IL2 neurons

et al. 2011

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“…Since defensive behavior command neurons of edible snail have both extrasynaptic [5] and postsynaptic [4,7] cholinoceptors, up-regulation of cholinoceptors recycling can increase the efficiency of interneuronal traffic for a short period during sensitization of the defensive reflex by elevation of sensitivity of the extrasynaptic and probably subsynaptic membrane regions to the neurotransmitter without synthesis of new transmitter receptors. This work was supported by the Russian Foundation for Basic Research, grant No.…”

Section: Resultsmentioning

confidence: 99%

Role of cholinoceptors recycling in short-term potentiation of cholinosensitivity of command neurons in edible snail

2007

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Exocytosis inhibitor Exo 1, dynamin inhibitory peptide (inhibitor of endocytosis), and colchicine disturb short-term potentiation of cholinosensitivity of defensive behavior command neurons in edible snail induced by rhythmic electrical orthodromic stimulation. We hypothesize that the short-term potentiation of cholinosensitivity in the extra-synaptic membrane develops due to incorporation of extra cholinoceptors into neuron plasmalemma as a result of enhanced recycling of the internalized cholinoceptors with participation of microtubules.

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“…These cells are command elements of withdrawal responses to noxious stimuli (Ierusalimskii et al 1992). The membranes of the cells contain extrasynaptic (Pivovarov and Drozdova 1992) and postsynaptic (Ter-Markaryan et al 1991;Palikhova et al 2006) cholinergic receptors.…”

Section: Registration Of Transmembrane Ionic Currentsmentioning

confidence: 99%

Habituation-Like Decrease of Acetylcholine-Induced Inward Current in Helix Command Neurons: Role of Microtubule Motor Proteins

2015

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The role of kinesin and dynein microtubuleassociated molecular motors in the cellular mechanism of depression of acetylcholine-induced inward chloride current (ACh-current) was examined in command neurons of land snails (Helix lucorum) in response to repeated applications of ACh to neuronal soma. This pharmacological stimulation imitated the protocol of tactile stimulation evoking behavioural habituation of the defensive reaction.In this system, a dynein inhibitor (erythro-9-(2-hydroxy-3-nonyl)adenine, 50 lM) decreased the ACh-current depression rate. Kinesin Eg5 inhibitors (Eg5 inhibitor III, 10 lM and Eg5 inhibitor V, trans-24, 15 lM) reduced the degree of current depression, and Eg5 inhibitor V also reduced the initial rate of depression. The results of electrophysiological experiments in combination with mathematical modelling provided evidence of the participation of dyneins and kinesin Eg5 proteins in the radial transport of acetylcholine receptors in command neurons of H. lucorum in the cellular analogue of habituation. Furthermore, these results suggest that the reciprocal interaction between dynein and kinesin proteins located on the same vesicle can lead to reverse their usual direction of transport (dyneins-in exocytosis and kinesin Eg5-in endocytosis).Keywords EHNA Á Eg5-inhibitor-III Á Eg5-inhibitor-V trans-24 Á Short-term depression of ACh-induced chloride current Á Command neurons Á Helix lucorum Á Habituation

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Cholinergic sensory inputs to command neurons in edible snail

Cited by 8 publications

References 5 publications

Nictation, a dispersal behavior of the nematode Caenorhabditis elegans, is regulated by IL2 neurons

Nictation, a dispersal behavior of the nematode Caenorhabditis elegans, is regulated by IL2 neurons

Role of cholinoceptors recycling in short-term potentiation of cholinosensitivity of command neurons in edible snail

Habituation-Like Decrease of Acetylcholine-Induced Inward Current in Helix Command Neurons: Role of Microtubule Motor Proteins

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