Cholinesterase, arylesterase et proteinuries. Essai d'application clinique dans les proteinuries glomerulaires et tubulaires

Vincent, D; Magron, J

doi:10.1016/0009-8981(78)90076-1

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1992

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“…ChE activities have been localized in the mammalian kidney by histochemical studies [8,9], Nevertheless, urinary ChE activity both in physiological [10] and pathological [11,12] conditions has scarcely been investi gated. So far no report at all has dealt with urinary ChE in diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

Urinary Cholinesterase Activity Is Increased in Insulin-Dependent Diabetics: Further Evidence of Diabetic Tubular Dysfunction

Matteucci¹,

Pellegrini²,

Uncini-Manganelli³

et al. 1992

Enzyme

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We measured the cholinesterase activity in morning urines from 63 insulindependent diabetics and 27 controls. The total esterase (TotE) activity (Ellman’s method) has been divided into aliesterase (AliE), pseudocholinesterase and acetylcholinesterase by means of two inhibitors, eserine and quinidine. Diabetics were divided in 2 groups according to the urinary albumin/creatinine ratio (mg/mmol, < 2 in group 1, > 2 in group 2). The urinary cholinesterase behavior was correlated with that of a known tubular lysosomal hydrolase, N-acetyl-β-D-glucosaminidase (NAG). Compared to normals, in addition to a significant increase in urinary NAG in diabetics (in group 2 more than in group 1 ), TotE and AliE were also significantly raised (+36% and 109% of the controls, in group 1 as much as in group 2).

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