Cholinesterase evaluation in the prenatal diagnosis of open neural tube defects

The polymorphism of the serum cholinesterase CHE 1 was determined using an automated micro-method. The procedure developed represents an improvement of the manual method and enabled us to study more than 2400 samples obtained in 15 different geographical areas in France. Four alleles were detected: CHE1* U, A, S and F. An exceptionally high frequency of an atypical variant (CHE1*A) was observed in the central part of France (Cevennes, Limousin and Dauphiné). The populations belonging to these areas are at particular risk in case of anaesthesia.

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Cholinesterase evaluation in the prenatal diagnosis of open neural tube defects

Cited by 2 publications

References 16 publications

Hydroxyproline and creatinine levels in normal amniotic fluid

Hydroxyproline and creatinine levels in normal amniotic fluid

Serum cholinesterase polymorphism in France: an epidemiological survey of the deficient alleles detected by an automated micro-method

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