Cholinesterase in serum and low density lipoprotein of hyperlipidemic patients

Chu, Mon Li; Fontaine, Patricia; Kutty, Karthiyanee; Murphy, D.; Redheendran, R

doi:10.1016/0009-8981(78)90100-6

Cited by 67 publications

(31 citation statements)

References 13 publications

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“…Re l a t i o n s h i p s b e t we e n Ad i p o s i t y , S e r u m L i p i d s , I n s u l i n Re s i s t a n c e , a n d Cl i n i c a l B a c k g r o u n d F a c t o r s E v a l u a t e Table 2). We were able to further show that even after adjustment for age, gender and HbA1c, the serum BChE activity was still correlated significantly with the HDL-C, TG and LDL-C (Table 3), confirming the previously reported association between the serum BChE activity and the lipid profile and hepatic fat content (6,7,9). We also examined whether the changes in the serum BChE activity were associated with changes in the L/S ratio, VFA and SFA at 1 year after the initial hospitalization in the patients ( We had previously demonstrated an association of the serum ferritin and serum CRP concentrations with the parameters of adiposity and degree of insulin resistance (16,17) …”

Section: T a B L E 3 Re L A T I O N S H I P S B E T We E N Ad I P Osupporting

confidence: 87%

“…(6)(7)(8)(9)(10). On the other hand, the relationship of radiologically measured abdominal fat accumulation and hepatic fat content to metabolic risk factors for atherosclerosis has been intensively investigated, and both the visceral fat area (VFA) and hepatic fat content are now recognized to be correlated with the plasma TG level and glucose utilization (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Serum Butyrylcholinesterase is Strongly Associated with Adiposity, the Serum Lipid Profile and Insulin Resistance

et al. 2007

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Objective We investigated the association between the serum butyrylcholinesterase (BChE) activity and parameters of adiposity, insulin resistance and the serum lipid profile, including the serum levels of triglyceride (TG), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) Results Serum BChE activity was significantly correlated with various indices of adiposity, including the waist circumference, L/S ratio, visceral fat area (VFA), subcutaneous fat area (SFA) and BMI, and also with the TG, HDL-C, LDL-C and HOMA-R, in the entire subject population. Even after adjustment for five variables, namely, age, gender, HbA1c, CRP and serum ferritin (the serum levels of ferritin and CRP have been reported to be associated with adiposity and insulin resistance), the serum BChE activity was still correlated with the waist circumference, L/S ratio, VFA, SFA, BMI, TG, HDL-C, LDL-C and

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Section: T a B L E 3 Re L A T I O N S H I P S B E T We E N Ad I P Osupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Serum Butyrylcholinesterase is Strongly Associated with Adiposity, the Serum Lipid Profile and Insulin Resistance

et al. 2007

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“…This explains the second factor. The mechanism by which the serum cholinesterase activity level varies is extremely complex but it is certain that at least protein and lipid metabolism are related in the fluctuations of the level of this enzyme (Chu et al, 1978;Cucuian et al, 1975;Kutty et al, 1981;Ryhsnen et al, 1982). In the present study, the group with a high cholinesterase level also exhibited increases in the serum lipid contents (such as serum total cholesterol and triglyceride contents).…”

Section: ) Subjectssupporting

confidence: 44%

Evaluation of the Effects of Various Factors on the Serum Cholinesterase Activity Level

Imaki¹,

Ohguri²,

Iuchi

et al. 1995

Jpn. J. Health Hum. Ecol

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“…Positive correlations between total BChE activity and total cholesterol levels have already been shown. 6,18,23 An increase in total BChE activity has already been detected in hyperthyroidism. 24,25 The negative correlation with E 2 is supported by data showing higher mean total BChE activity in men than in women in the fertile period, a difference that disappears after menopause.…”

Section: Discussionmentioning

confidence: 96%

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

et al. 2003

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OBJECTIVE:To investigate the association between butyrylcholinesterase (BChE) activities (total and band specific) and body mass index (BMI) in obese and nonobese individuals, considering other variables (anthropometric, biochemical and hormonal) and the leanness process. SUBJECTS: Obese (BMIZ30 kg/m 2 ; N ¼ 181) and nonobese individuals (N ¼ 265), classified according to the CHE2 locus phenotypes, with the obese patients being followed-up when submitted to a weight-loss program. MEASUREMENTS: Anthropometric (weight, height, BMI, waist, waist/hip ratioFWHR, triceps and subscapular skinfolds, percentage of body fat and arterial pressures), hormonal (insulin, estradiolFE 2 , triiodothyronineFT 3 and thyroxineFT 4 ) and biochemical (glucose, total cholesterol, HDL-C, triglycerides, uric acid, urea, creatinine, sodium, potassium and BChE activities) variables. RESULTS: Although obese CHE2 C5À individuals presented higher mean BChE activities than their CHE2 C5À controls and diminished mean activities with leanness, similar comparisons did not show any difference in the CHE2 C5 þ group. Furthermore, the mean serum potassium values of obese individuals were significantly higher in the CHE2 C5 þ than in the CHE2 C5À phenotype. The BChE activities were less related to BMI in obese CHE2 C5À individuals than in their controls. In the CHE2 C5À obese group, significant regression coefficients were found between BChE activity variables and BMI ( þ ), ethnic origin (higher in Euro-Brazilians), sex (higher in males), diastolic pressure (À), triceps skinfold ( þ ), total cholesterol ( þ ), T 3 ( þ ) and E 2 (À). The main findings in the CHE2 C5 þ obese group: mean insulin levels decreased with leanness and a significant correlation was detected between the C 5 complex activity and creatinine ( þ ), insulin (À) and WHR (À); a significantly higher frequency of weight loss occurred compared to the CHE2 C5À group. CONCLUSION: In the present study, different relations between obesity and some of the studied variables were found when CHE2 C5 þ and CHE2 C5À individuals were compared.

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Cholinesterase in serum and low density lipoprotein of hyperlipidemic patients

Cited by 67 publications

References 13 publications

Serum Butyrylcholinesterase is Strongly Associated with Adiposity, the Serum Lipid Profile and Insulin Resistance

Serum Butyrylcholinesterase is Strongly Associated with Adiposity, the Serum Lipid Profile and Insulin Resistance

Evaluation of the Effects of Various Factors on the Serum Cholinesterase Activity Level

Butyrylcholinesterase and obesity in individuals with the CHE2 C5+ and CHE2 C5− phenotypes

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