Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii

Hung, Tran Manh; Na, MinKyun; Dat, Nguyen Tien; Ngoc, Tran Minh; Youn, Ui Joung; Kim, Hee Jin; Min, Byung‐Sun; Lee, JongPill; Bae, KiHwan

doi:10.1016/j.jep.2008.05.041

Cited by 77 publications

(56 citation statements)

References 30 publications

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“…The inhibitory activities of the compounds against ChE were measured using the spectrophotometric method developed by Ellman with some modifications [8]. Acetylcholine (ACh) and butyrylcholine (BCh) were used as substrates to assay the inhibition of AChE and BChE, respectively.…”

Section: In Vitro Che Inhibitory Activity Assaymentioning

confidence: 99%

Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II)

Hung

Lee

Chuong

et al. 2015

Chemico-Biological Interactions

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Section: In Vitro Che Inhibitory Activity Assaymentioning

confidence: 99%

Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II)

Hung

Lee

Chuong

et al. 2015

Chemico-Biological Interactions

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“…Wang, has been used as a folk medicine for its analgesic and anti-ulcer effects. [17][18][19] DA-9701 has shown affinity for the dopamine (D) 2 , 5-hydroxytryptamine (5-HT) 4 , 5-HT 1A , and 5-HT 1B receptors. 13,11,15 It has antagonistic effects on the D 2 receptors and agonistic effects on the 5-HT 4 , 5-HT 1A and 5-HT 1B receptors.…”

mentioning

confidence: 99%

The Effect of DA-9701 in Opioid-induced Bowel Dysfunction of Guinea Pig

Hussain

Rhee

Lee

et al. 2016

J Neurogastroenterol Motil

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Background/AimsOpioid induced bowel dysfunction (OIBD) is associated with decreased gastrointestinal (GI) propulsive activity due to intake of opioid analgesics. DA-9701, a novel prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber has promising effects on GI motor function. Therefore, we aim to evaluate the prokinetic effects of DA-9701 in an OIBD model of guinea pig. MethodsThe ileal and distal colon muscle contraction in presence of different doses of DA-9701, morphine, and combination (morphine + DA-9701) was measured by tissue bath study. The prokinetic effect of DA-9701 was assessed by charcoal transit and fecal pellet output assay in an OIBD model of guinea pig.Results DA-9701 significantly increased the amplitude and area under the curve of ileal muscle contraction, while there was insignificant effect on the distal colon compared to the control. The maximal amplitude of ileal muscle contraction was acquired at a concentration of 10 μg/mL of DA-9701. In contrast, morphine significantly decreased the amplitude of ileal and distal colon muscle contraction compared to the control. Morphine delayed both upper (P < 0.01) and lower (P < 0.05) GI transit, and delayed GI transit was restored by the administration of DA-9701. Morphine induced reduction of contractility was significantly ameliorated by addition of DA-9701 in both ileal and distal colon muscles. ConclusionsDA-9701 significantly increased the amplitude of contraction of the ileal muscle, however the distal colon muscle contraction was insignificant. Additionally, it restored delayed upper and lower GI transit in an OIBD model of guinea pig, and it might prove to be a useful candidate drug in a clinical trial for OIBD. (J Neurogastroenterol Motil 2016;22:529-538)

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“…It has been reported that Corydalis tuber extracts exhibit several biological activities, acting as both an anti-spasmodic agent in the GI tract and as an analgesic. [5][6][7][8] Previous phytochemical studies reported that Corydalis tubers are made up primarily of alkaloid compounds including corydaline, berberine, protopine, and palmatine. [8][9][10][11][12] These alkaloid compounds are reported to provide the analgesic, anti-spasmodic, and anti-acetylcholinesterase activities associated with Corydalis tubers.…”

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Effects of Corydaline from Corydalis Tuber on Gastric Motor Function in an Animal Model

Lee

Son

Kim

2010

Biological & Pharmaceutical Bulletin

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Functional dyspepsia (FD) is a highly prevalent chronic gastrointestinal (GI) disorder that causes a considerable burden to both the patient and society. Although the etiology and pathogenesis of FD are poorly understood, FD is associated with pathophysiologic abnormalities including delayed gastric emptying (GE), impaired gastric accommodation, and visceral hypersensitivity.1,2) Delayed GE has been reported in 30-40% of FD patients, 3) and a number of studies have demonstrated impaired gastric accommodation after meals in approximately 40% of patients. 4) Given these results, we hypothesized that GE of a semi-solid meal, GI transit, and gastric accommodation would be suitable markers for evaluating motor effects in animal models.Corydalis tubers, the roots of Corydalis yahusuo W.T. WANG (Papaveraceae), have long been used as herbal medicine for their analgesic and anti-ulcer effects. It has been reported that Corydalis tuber extracts exhibit several biological activities, acting as both an anti-spasmodic agent in the GI tract and as an analgesic. [5][6][7][8] Previous phytochemical studies reported that Corydalis tubers are made up primarily of alkaloid compounds including corydaline, berberine, protopine, and palmatine. [8][9][10][11][12] These alkaloid compounds are reported to provide the analgesic, anti-spasmodic, and anti-acetylcholinesterase activities associated with Corydalis tubers. Of these compounds, corydaline is considered the marker compound for quality control of Corydalis extract; however, the pharmacological effects of corydaline on GI motor function have not yet been studied.We previously investigated the prokinetic activities of corydaline to determine its potential bioactivity in FD and elucidated the basis of the selection of corydaline as the principal marker compound for quality control. 13) In the present study, we evaluated the effects of corydaline on GE and GI transit in rats and gastric accommodation in conscious dogs. MATERIALS AND METHODS Plant MaterialPlant material was commercially purchased at Kyungdong herbal market (Seoul, Korea) and identified by Dr. S. Choi at the Research Center of Dong-A Pharm. Co., Ltd. (Yongin-si, Korea). A voucher specimen has been deposited in our laboratory at Kyung Hee University.Extraction and Isolation Dried Corydalis tuber (30 kg) was extracted with 50% aqueous ethanol three times at room temperature. Upon removal of the solvent under vacuum, the ethanolic extract yielded 2.85 kg of material (Corydalis tuber extract, CTE; 7.6% by dry weight). We found that the CTE contained corydaline, palmatine, berberine, and other isoquinoline alkaloids. Based on HPLC analysis, the prescribed range of index components including corydaline and palmatine was detected in the CTE. The CTE was suspended in H 2 O and partitioned successively with n-hexane, ethyl acetate (EtOAc), and n-butanol. The EtOAc-soluble fraction (15 g) of the extract was subjected to a silica gel column using mixtures of n-hexane-EtOAc of increasing polarity as eluents to give 12 sub-fraction...

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Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii

Cited by 77 publications

References 30 publications

Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II)

Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II)

The Effect of DA-9701 in Opioid-induced Bowel Dysfunction of Guinea Pig

Effects of Corydaline from Corydalis Tuber on Gastric Motor Function in an Animal Model

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