Cholinesterases Inhibition by Novelcis- andtrans-3-ArylaminocyclohexylN,N-Dimethylcarbamates: Biological Evaluation and Molecular Modeling

Yamazaki, Diego Alberto dos Santos; Cândido, Augusto A.; Bagatin, Mariane Cristovão; Machinski, Miguel; Mossini, Simone Aparecida Galerani; Pontes, Rodrigo M.; Rosa, Fernanda A.; Basso, Ernani A.; Gauze, Gisele F.

doi:10.5935/0103-5053.20160041

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2019

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“…5,6 One of the enzymes involved in these biological processes is acetylcholinesterase (AChE), which is capable of regulating the process of neurotransmission and the levels of acetylcholine in the synaptic cleft, since it is able to catalyze the hydrolysis of this neurotransmitter. 7 For this reason, many studies of theoretical and experimental nature have been developed with the purpose of finding compounds with ability to inhibit the enzyme acetylcholinesterase. 6 Thus, the first drugs used for the symptomatic treatment of Alzheimer's disease act in a way to selectively inhibit AChE.…”

Section: Introductionmentioning

confidence: 99%

Functionalized Dienes: A New Series of Potential Agents for the Treatment of Alzheimer’s Disease

Oliveira¹,

Meier²,

Zapp³

et al. 2019

J. Braz. Chem. Soc.

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We report a series of functionalized dienes as compounds of great potential in the treatment of Alzheimer's disease due to their antioxidant activity and ability to inhibit the enzyme acetylcholinesterase. The dienes tested showed high enzymatic inhibition capacity and accentuated antioxidant activity, which are comparable to or higher than the standards tested. Molecular docking studies were performed to confirm the experimental results. We also describe the correlation values between the antioxidant activity and oxidation potentials. Predicted bioactivity scores and quantum studies were also determined.

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Section: Introductionmentioning

confidence: 99%