Chondrocalcinosis Articularis: Section III. Physiopathological Study

Zitnan, D; Sitaj, S; Hüttl, S; Skrovina, B; Hanic, F; Marković, Olivera; Trnavská, Z

doi:10.1136/ard.22.3.158

Cited by 14 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Factors that have been considered of pathogenetic significance in the calcium pyrophosphate type of articular chondrocalcinosis include: an abnormality in pyrophosphate metabolism [ 171, a defect in articular chondrocytes [ 191, a metabolic abnormality in formation of cartilage [25], altered synthesis of intercellular substance, and high tissue levels of prostaglandin Ez [4]. In hydroxyapatite-type chondrocalcinosis, the finding of soft tissue mineralization adds an additional factor that may indicate that mineralization results from a metabolic defect that causes a generalized connective tissue disorder.…”

Section: Discussionmentioning

confidence: 99%

Calcium Phosphate Deposition Disease in Great Danes

et al. 1982

View full text Add to dashboard Cite

Abstract.A new clinicopathologic syndrome, possibly familial, in Great Dane dogs, resembles the familial childhood variant of calcium pyrophosphate dihydrate deposit disease in man, except that the mineral deposits were composed of amorphous calcium phosphate or hydroxyapatite rather than pyrophosphate. The syndrome was characterized clinically by paraplegia and incoordination in very young puppies which was caused by concentric constriction of the posterior cervical spinal cord. Canal stenosis resulted from dorsal displacement of the seventh cervical vertebra and deformation of the vertebral articular processes. Mineral deposition in the diarthrodial joints of the axial skeleton could be seen on radiographs of weanling puppies, and the appendicular skeleton became involved as the dogs matured. Periarticular mineralization of the limbs was associated with shorter bones, a thin cortex, abnormal bone curvature, and increased medullary trabeculae. Bone alterations were associated with abnormalities of the growth plate, which had focal areas of cartilage calcification. Soft tissue mineralization, seen in all dogs, was a primary feature of the disease process. Serum calcium concentrations were within the normal range, but serum phosphorus concentrations were decreased.Crystal deposition disease is a current term for various types of crystal-induced synovitis. Gout was the first condition identified in which acute synovitis was associated with urate crystals in the synovial fluid. In calcium pyrophosphate dihydrate crystal deposition disease, the second form of the disease to be described, acute joint inflammation was associated with crystals of calcium pyrophosphate dihydrate rather than urates.

show abstract

Section: Discussionmentioning

confidence: 99%

Calcium Phosphate Deposition Disease in Great Danes

et al. 1982

View full text Add to dashboard Cite

show abstract

Polyarticular and familial chondrocalcinosis

Reginato

Valenzuela

Martı́nez

et al. 1970

Arthritis & Rheumatism

View full text Add to dashboard Cite

From our series of 72 patients with articular chondrocalcinosis, 37 who presented polyarticular involvement are described. Twenty‐eight patients, including 19 aggregated within different family groups, are natives of the Chiloé island group. Members of 1 of the 6 families had unusually severe disease with deformities, and 1 had bony ankylosis of multiple joints. Pathologic findings in both the acute and the chronic stages of the joint disease are presented, particularly, some severe changes that have not been described previously.

show abstract

The articular cartilage in familial chondrocalcinosis. Light and electron microscopic study

Reginato

Schumacher

Martı́nez

1974

Arthritis & Rheumatism

View full text Add to dashboard Cite

Cartilage has been studied from 12 patients with different degrees of chondrocalcinosis. Degenerative changes and patches of decreased saphranin 0 staining were present even in areas without calcium deposits. Alkaline phosphatase was identified only in the basal layer and was slightly decreased. By electron microscopy mildly involved cartilage showed small diameter isolated crystals lying in a finely granular material. Similar granular material, staining dark with ruthenium red, was present around the crystalline deposits of the knee menisci. No intracellular crystals were seen and no relationship between crystals and the matrix vesicles was observed. This study suggests that the inital deposition of calcium pyrophosphate crystals is in the interstitium of the cartilage. The smallest deposits lie in a yet unidentified dense material that may be glycosaminoglycan.Studies of physiologic hydroxyapatite calcification of epiphyseal cartilage have shown that the first mineral deposits are in the matrix vesicles (12). The manner of initial calcium pyrophosphate deposition in the articular cartilage is not known and has received little study (3).Light microscopic studies of the articular cartilage in established chondrocalcinosis

show abstract

Chondrocalcinosis Articularis: Section III. Physiopathological Study

Cited by 14 publications

References 0 publications

Calcium Phosphate Deposition Disease in Great Danes

Calcium Phosphate Deposition Disease in Great Danes

Polyarticular and familial chondrocalcinosis

The articular cartilage in familial chondrocalcinosis. Light and electron microscopic study

Contact Info

Product

Resources

About