Chondrocyte Apoptosis in Response to Dislocation of the Hip in the Rat Model

Elliott, Johanna; Ng, De Juan; Tham, Stephen

doi:10.1111/j.1445-2197.2006.03730.x

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…18 In case the femoral head was unsalvageable, a hip arthroplasty was performed. Other strategies we used to preserve cartilage was prompt hip reduction, which was proven to lower apoptosis of chondrochytes, 19 concentric acetabular reduction and early hip motion exercises. We believe that those combined strategies lowered our rates of early arthritis to 30% compared to 88% in earlier studies.…”

Section: Discussionmentioning

confidence: 99%

Medium-term outcome and classification of traumatic anterior hip dislocations

et al. 2020

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Introduction: Traumatic anterior hip dislocations are subdivided to obturator (inferior) and pubic (superior) dislocations by Epstein’s descriptive classification. This rare injury is thought to have favourable clinical outcomes. The incidence of associated femoral head and acetabular injuries has been low in past case series. We sought to revisit this injury and classification in the era of advanced imaging and contemporary surgical techniques. Materials and methods: A retrospective study of 15 patients treated for anterior hip dislocation was performed. Medical records were reviewed for demographic and surgical data. Imaging studies were revisited to determine direction of dislocation and associated fractures. Patients were assessed for pain, hip function using the modified Harris Hip Score (mHHS), hip range of motion and radiographic changes. Mean follow-up time was 3 years. Results: Anterior dislocation occurred in an obturator (inferior), pubic (superior) or central direction. 9 patients had concomitant femoral head impaction and 7 patients suffered from acetabular fractures. 8 patients with an anterior hip dislocation underwent surgical treatment. This therapy, along with early range of motion and weight bearing, produced favourable clinical outcomes with 9 patients reporting no pain and an average mHHS of 83.8. 6 patients had heterotopic ossification at latest follow-up. Conclusions: Traumatic anterior hip dislocation is commonly associated with femoral head impaction and acetabular injuries which should be addressed operatively when appropriate to produce favourable results. In this paper, we propose a revision to the commonly used descriptive classification system.

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Section: Discussionmentioning

confidence: 99%

Medium-term outcome and classification of traumatic anterior hip dislocations

et al. 2020

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“…The mean apoptotic index of the control groups in this study was between 0.04 and 0.12. The femoral head apoptotic index rates in other studies ranged from 0.01 to 0.23 [25][26][27]. D'Lima thought that this was related to the artifacts in the culture and cutting technique of the pathological specimens [26][27][28].…”

Section: Discussionmentioning

confidence: 91%

“…However, Dreinhofer et al [3] showed that even if the hip reduction was achieved within the first 6 hours, AVN developed in the femoral head in the long term. In the animal study conducted by Elliot et al [25], dislocation of the rat hip joint for more than 1 hour caused a significant increase in the apoptotic index. In our study, the apoptotic index significantly increased with the duration of dislocation in both the experimental and the control groups.…”

Section: Discussionmentioning

confidence: 92%

The effect of platelet-rich plasma on chondrocyte healing in traumatic dislocation of the hip in a rat model

Savaş¹,

Buyukbebeci

Öğümsöğütlü

et al. 2021

Journal of Surgery and Medicine

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Background/Aim: Traumatic hip dislocations (THD) are orthopedic emergencies and significant complications such as cartilage degeneration can be reduced with early reduction. This study aimed to examine the effect of platelet-rich plasma (PRP) on cartilage cells in one-, two-or 8-hours prolonged hip dislocation. Methods: We used 24 Sprague-Dawley rats in this study and divided them into three main groups based on whether their hips were in the protruding position for one, two, or eight hours. Each main group was further divided into two subgroups, with the right hips constituting the experimental group and the left hips, the control group. Traumatic hip dislocation modeling was performed surgically on both hips of the rats under anesthesia in the same session. After both dislocated joints were reduced and the hip capsules were sutured, platelet-rich plasma was administered to the right hips. After 1 week, all rats were sacrificed, their femoral heads were excised and subjected to histopathological examination. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) testing was used to show chondrocyte apoptosis in the femoral head. The apoptotic index (AI) showing the ratio of cartilage cells to apoptosis was calculated histopathologically. A comparison of apoptotic indices was made between the groups. Results:The AIs of the one-, two-and eight hours-long hip dislocation groups were 0.012 (0.005), 0.023 (0.011), 0.046 (0.012), respectively (P<0.001), while those of the control groups were 0.028 (0.010), 0.077 (0.015), 0.100 (0.016), respectively (P<0.001). Conclusion:In traumatic hip dislocation known to cause chondrocyte apoptosis, PRP provides a significant reduction in the apoptotic index.

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“…15 Furthermore, new laboratory evidence suggests that a prolonged dislocation time will increase in chondrocyte apoptosis, as shown when increasing time to reduction for hip dislocation in a rat model. 16 Similarly, Torzilli et al 17 reported subchondral fractures and decreased metabolic activity in cartilage exposed to a compression injury.…”

Section: E 2f 2h 2gmentioning

confidence: 98%

Emergent Surgical Reduction and Fixation for Pipkin Type I Femoral Fractures

Lin¹,

Lian²,

Chen³

et al. 2013

Orthopedics

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The purpose of this study was to assess the effect of timing of large fragment fixation in patients with Pipkin type-I fractures. Patients with Pipkin type-I fractures from the authors' trauma center were prospectively observed between July 2007 and July 2010. Fragments that constituted more than one-fourth of the femoral head were included. Thirty-six patients were equally randomized to undergo emergent surgical reduction and fixation or secondary operative fixation after emergent closed reduction. No significant differences existed between the 2 groups with regard to the baseline characteristics, operating time, and blood loss (P>.05). However, the emergent surgical reduction and fixation group had a shorter hospital stay (P<.05). The results after more than 2-year follow-up showed that the complication and avascular necrosis rates were higher in the secondary operative fixation after emergent closed reduction group compared with the emergent surgical reduction and fixation group (P<.05). It was difficult to achieve an anatomically reduced femoral head when the fragments constituted more than one-fourth of the femoral head. Patients who underwent secondary operative fixation after emergent closed reduction had a high avascular necrosis rate and a relatively poor outcome. Emergent surgical reduction and fixation should be performed shortly after injury to enhance the treatment outcome.

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Chondrocyte Apoptosis in Response to Dislocation of the Hip in the Rat Model

Abstract: Dislocation of a joint causes chondrocyte apoptosis. There is a progressive increase in the apoptotic index with prolonged dislocation of the rat hip.

Cited by 5 publications

References 24 publications

Medium-term outcome and classification of traumatic anterior hip dislocations

Medium-term outcome and classification of traumatic anterior hip dislocations

The effect of platelet-rich plasma on chondrocyte healing in traumatic dislocation of the hip in a rat model

Emergent Surgical Reduction and Fixation for Pipkin Type I Femoral Fractures

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