Chondrocytes

Stockwell, R. A.

doi:10.1136/jcp.31.suppl_12.7

Cited by 58 publications

(45 citation statements)

References 31 publications

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“…Arbitrarily, chondrocytes have been divided into distinct regions (Zones I-III) of AC (102) and separated from subchondral bone by a calcified stratum (Zone IV) (Fig. 2).…”

Section: Basic Concepts In the Biology Of Acmentioning

confidence: 99%

Review Article: Quinolone Arthropathy—Acute Toxicity to Immature Articular Cartilage

Gough¹,

Kasali²,

Sigler³

et al. 1992

Toxicol Pathol

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A class effect of quinolone antibacterial agents observed during animal toxicity testing is a specific arthropathy (QAP). Despite the growing list of laboratory animals susceptible to QAP and reports of arthralgia in patients treated with quinolones, the potential for QAP development in humans remains unknown. This review discusses current concepts in the biology of articular cartilage and how these concepts elucidate QAP pathogenesis. Biomechanical forces within synovial joints and toxicokinetic properties of quinolones contribute to QAP induction. Since a limited number of mechanistic pathways exist for acute articular damage, QAP may serve as a research tool to probe the pathobiology of injury to articular cartilage.

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“…Arbitrarily, chondrocytes have been divided into distinct regions (Zones I-III) of AC (102) and separated from subchondral bone by a calcified stratum (Zone IV) (Fig. 2).…”

Section: Basic Concepts In the Biology Of Acmentioning

confidence: 99%

Review Article: Quinolone Arthropathy—Acute Toxicity to Immature Articular Cartilage

Gough¹,

Kasali²,

Sigler³

et al. 1992

Toxicol Pathol

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show abstract

“…It is in the proportion of energy given to producing the pro-teoglycans that chondrocytes (see R. A. Stockwell (Stockwell, 1978) at page 7) differ most obviously from fibroblasts. Chondrocytes synthesise and export much collagen and sometimes elastic material; but the cytological recognition of chondrocyte-rich tissues such as hyaline articular cartilage is most readily affected by identifying the abundant, proteoglycan-containing matrix.…”

Section: Summary Of New Knowledgementioning

confidence: 99%

Diseases of connective tissue: a consensus

Gardner¹

1978

Journal of Clinical Pathology

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“…The organization of the CHs exhibits a depth-dependent density variation (Jadin et al, 2005) on which the classification into superficial (0-10% tissue depth), middle (10-40%), and deep (40-100%) cartilage zones with distinct compositions, structures, and functions is based (Hunziker, 1992). In the deeper zones, the cell density is very low, and CHs are arranged in vertical columns (Stockwell and Meachim, 1979). In strong contrast, the superficial zone cell density is relatively high and CHs are arranged horizontally in groups at the articular surface (Stockwell and Meachim, 1979).…”

Section: Introductionmentioning

confidence: 98%

“…In the deeper zones, the cell density is very low, and CHs are arranged in vertical columns (Stockwell and Meachim, 1979). In strong contrast, the superficial zone cell density is relatively high and CHs are arranged horizontally in groups at the articular surface (Stockwell and Meachim, 1979).…”

Section: Introductionmentioning

confidence: 98%