Chondrodystrophy in calves associated with manganese deficiency

Elizondo, Germán Valero; Alley, M.R.; Badcoe, L.M.; Manktelow, B.W.; Merrall, M.; Lawes, G.S.

doi:10.1080/00480169.1990.35645

Cited by 26 publications

(18 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24 Growth-plate irregularity with reduced and disorderly proliferating chondrocytes and absence of hypertrophic chondrocytes, with residual necrotic remnants among fibrillar matrix, was described in another field outbreak putatively associated with manganese deficiency. 28 Respiratory difficulty has been a common factor in this and in other investigations 18,24 and may represent abnormalities of the tracheal cartilage rings leading to reduced luminal diameter, distorted nasal passages, or a combination of these and other factors. Calves not so severely affected as to die in the perinatal period in outbreaks of postulated manganese deficiency have reportedly shown limited-to-good clinical improvement with time, if assistance is given to feed and stand, with reduction in deformation but residual stunting, as noted in this outbreak.…”

Section: Discussionmentioning

confidence: 99%

“…Calves not so severely affected as to die in the perinatal period in outbreaks of postulated manganese deficiency have reportedly shown limited-to-good clinical improvement with time, if assistance is given to feed and stand, with reduction in deformation but residual stunting, as noted in this outbreak. 28 …”

Section: Discussionmentioning

confidence: 99%

“…9,14,26,27 Deficiency of manganese has been associated experimentally and clinically with reduced reproductive performance 7,22 and skeletal abnormalities 7,10,22,24,28 in calves and laboratory animals and with ataxia associated with abnormal development of the otoliths in laboratory rodents but not cattle. 13 …”

Section: Manganese In Skeletal Diseasementioning

confidence: 99%

“…Manganese deficiency was suspected, although not conclusively proven, in several previous field outbreaks of skeletal disease in calves. 24,28 This article presents the gross and histopathologic features of 2 outbreaks of congenital disease in calves, defines the disease, and discusses the potential relationship with manganese deficiency.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Chondrodysplastic Calves in Northeast Victoria

McLaren¹,

Cave²,

Parker³

et al. 2007

Vet Pathol

View full text Add to dashboard Cite

Abstract. Outbreaks of chondrodysplasia in calves occur sporadically every 10-15 years, particularly following prolonged drought conditions, throughout Northeastern Victoria and the Southern Table-lands of New South Wales, Australia. An outbreak spanning 2 calving seasons (2003)(2004) involving numerous losses through stillbirth, perinatal loss, and poor growth was investigated. Investigations of 4 representative cases are presented here with a definition of the gross and histopathologic defects and an overview of epidemiologic data gathered from affected farms. Calves showed variable disproportionate dwarfism without arthrogryposis. Long bones were shortened and showed axial rotation. Articular surfaces were distorted with misshapen weight-bearing surfaces associated with variable thickness of articular cartilage. Physes were distorted and variable in thickness with occasional foci of complete closure. The major histologic abnormality in the physes was disorderly development of the zones of cartilage hypertrophy, with reduced number and irregular arrangement of hypertrophic chondrocytes; similar less severe changes were present in the zones of cartilage proliferation. Histochemical staining of the cartilage matrix was variable in intensity, and there was evidence of abnormal resorption of cartilage matrix at the level of the primary spongiosa. Osteoid formation and subsequent bone remodelling seemed unaffected, and diaphyseal cortical bone appeared normal at the gross and light microscopic level. No infectious agents were identified, and other known causes for chondrodysplasia in calves were excluded. The most likely cause for the syndrome was considered to be congenital manganese deficiency. Further surveys of tissue and blood manganese levels from cows and calves with and without clinical signs from the region are planned.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Manganese In Skeletal Diseasementioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Chondrodysplastic Calves in Northeast Victoria

McLaren¹,

Cave²,

Parker³

et al. 2007

Vet Pathol

View full text Add to dashboard Cite

show abstract

“…A previous attempt to investigate risk factors for CCUO using limited available data on an outbreak in 1991 suggested an association with low pasture availability and supplemental feeding (White et al, 2009). The possibility that CCUO occurrence is associated with nutritional factors is also confirmed from studies into similar cases of CCOU in other countries (Gunn et al, 1997;Mee, 2001;Ribble et al, 1989;Staley et al, 1994;Valero et al, 1990). The implication of a nutritional disturbance involving trace mineral availability warrants inclusion in any study where possible (Hidiroglou, 1980).…”

Section: Introductionmentioning

confidence: 50%

Risk factors for congenital chondrodystrophy of unknown origin in beef cattle herds in south-eastern Australia

White

Windsor

Dhand

et al. 2010

Preventive Veterinary Medicine

View full text Add to dashboard Cite

A case control study was conducted on 46 farms in south eastern Australia with a recent history of congenital chondrodystrophy of unknown origin (CCUO) between 2002 and 2007. For each farm data was collected using face-to-face interviews concerning the management of case and control mobs during the gestation period in which affected calves were born. Data concerning the paddocks in which gestating cattle were maintained was also collected for analysis. Three separate multivariable models were constructed using generalised linear mixed models (GLMM). The first model was based on the dichotomous outcome of mob status (affected/not affected) and included explanatory variables for management and environment factors. The second model used a novel approach, taking into account the number of cases in affected mobs in order to utilise available data. The outcome events/ trials was used where the numerator was equal to the number of affected calves in a mob, and the denominator was equal to the total number of calves in the mob. The third model used the dichotomous outcome paddock status and included environmental and soil variables for paddocks involved with case and control mobs. Confounding for dam age and year affected was included in the mob outcome models, and random effects for paddock and farm were incorporated into the models. The birth of CCUO calves was associated with dams grazing native pastures on hilly terrain during gestation. Low levels of pasture were also associated with the outcome. The two models used for the mob outcome were similar in many respects. The 2 events/trial model included the use of supplemental feed and an interaction term. This study demonstrates an association between a maternal nutritional disturbance and the occurrence of CCUO.

show abstract

Manganese-responsive congenital carpus valgus in a calf (first report in veterinary literature)

Mozaffari

Vosough

2010

Comp Clin Pathol

View full text Add to dashboard Cite

Chondrodystrophy in calves associated with manganese deficiency

Cited by 26 publications

References 12 publications

Chondrodysplastic Calves in Northeast Victoria

Chondrodysplastic Calves in Northeast Victoria

Risk factors for congenital chondrodystrophy of unknown origin in beef cattle herds in south-eastern Australia

Manganese-responsive congenital carpus valgus in a calf (first report in veterinary literature)

Contact Info

Product

Resources

About