Chondroid Syringoma Mimicking Basal Cell Carcinoma

Chondroid syringoma: unusual presentation of a rare tumor

“…1 Geralmente, apresenta-se como tumor sólido, único, assintomático, localizado na face ou pescoço, de evolução crônica, cujo diagnóstico é determinado pela análise histopatológica. 2 Relata-se caso de mulher, 75 anos, com lesão discretamente elevada na fronte.…”

Chondroid Syringoma with Extensive Cartilaginous Differentiation

“…[ 1 2 ] Common locations are head and neck, yet extremities, chest, abdomen, and genital area have been reported. [ 1 2 3 4 ] Usually affects middle-aged men presenting as firm, painless, well-demarcated tumor. [ 1 2 ] Characteristic appearance of both components (epithelial, mesenchymal) within chondromyxoid stroma can be accompanied by skin adnexal structures (hair follicles, sebaceous glands, and apocrine glands), osseous tissue, and cartilage.…”

“…This tumor is characterized by both epithelial elements demonstrating apocrine or eccrine differentiation and mesenchymal component comprised of myxoid or collagenous matrix. [ 1 ] Dermoscopic pattern is nonspecific, undefined, and insufficient for the diagnosis;[ 3 ] thus, the diagnosis is obtained through pathohistological analysis according to the presence of one or combination of cuboidal or polygonal cells nests, tubuloalveolar structures, keratinous cysts, matrix (myxoid, chondroid, adipocytic, fibrous), and ductal structures with one or two rows of cuboidal cells. [ 1 2 5 ] Initially, fine needle aspiration (FNA) cytology can be performed revealing chondromyxoid matrix containing uniform plasmacytoid and epithelial cells.…”

“…Most similar to chondroid syringoma is pleomorphic adenoma; however, differential diagnosis of chondroid syringoma includes pleomorphic adenoma, other adnexal tumors (cylindroma, hidradenoma, and spiradenoma), as well as pilomatrixoma and basal cell carcinoma[ 3 4 ] [ Table 1 ].…”

“…Rarely, chondroid syringoma undergoes malignant transformation characterized by a different location (usually extremities), larger size (>3 cm), infiltrative and rapid growth, deeper tissue involvement, necrosis, cytologic atypia, atypical mitoses, and satellite nodules. [ 1 2 3 ] It requires a more radical approach combining surgery, radiotherapy, and chemotherapy. [ 1 ]…”