Chondroitin for osteoarthritis

Singh, Jasvinder A.; Noorbaloochi, Siamak; MacDonald, Roderick; Maxwell, Lara

doi:10.1002/14651858.cd005614.pub2

Cited by 181 publications

(133 citation statements)

References 91 publications

(438 reference statements)

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“…31,43,61) High-dose CS therapy was tolerable in the present study, and there was no increased drop-off rate compared to low-dose therapy. Also consistent with previous studies, we showed that there were no serious adverse effects attributable to CS and that tolerability was good.…”

supporting

confidence: 46%

“…[4][5][6][7][28][29][30] Singh et al recently conducted a review of randomized trials of OA interventions in the Cochrane Database of Systemic Reviews and concluded that CS may improve pain, that it probably improves QOL, and that it probably slows down narrowing of the joint space in patients with knee OA. 31) However, there have also been reports showing no effects of CS on pain or cartilage structure. 6,32,33) It is possible that differences in disease severity among patients caused the discrepancy in the effect of CS on OA symptoms among studies.…”

mentioning

confidence: 99%

“…[4][5][6][7][28][29][30][31] Recently, various biomarkers have been developed to detect the articular alterations in OA, and accumulating evidence suggests that there are associations with changes in ECM protein components in the cartilage and synovium as disease progresses in knee OA. 45,46) Finding the level of COMP in serum allows defining the degree of cartilage damage in OA 47,48) and observing effectiveness of the treatment.…”

mentioning

confidence: 99%

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Efficacy of Chondroitin Sulfate for Painful Knee Osteoarthritis: A One-Year, Randomized, Double-Blind, Multicenter Clinical Study in Japan

Morita

Yamada

Date

et al. 2018

Biological & Pharmaceutical Bulletin

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We explored the effects of chondroitin sulfate on knee osteoarthritis in a one-year, randomized, doubleblind, dose-comparison study. Patients with painful, Kellgren-Lawrence grade 2-3, osteoarthritis of the knee were treated with oral chondroitin sulfate at a dose of either 260 mg/d (low-dose group, control group) or 1560 mg/d (high-dose group). Symptoms were evaluated by the Lequesne's index and visual analog scale for pain. We made subgroup analyses according to background symptom severity (Lequesne's index ≥8 or <8) in 73 patients. Serum level of cartilage oligomeric matrix protein and hyaluronic acid were also determined. In the subgroup with severe symptoms (Lequesne's index ≥8), the chondroitin sulfate dose of 1560 mg/d improved pain faster after 6 and 9 months' therapy. However, no dose-related effects were found on cartilage oligomeric matrix protein or hyaluronic acid levels. Chondroitin sulfate also had good tolerability. We conclude that chondroitin sulfate is useful for pain control in knee osteoarthritis.Key words chondroitin sulfate; pain-management; clinical trial; randomized controlled trial Osteoarthritis (OA) is the most common form of arthritis and is a major cause of morbidity, activity limitation, physical disability, excess health care utilization, and reduced healthrelated QOL, especially in people aged 65 years and older.

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supporting

confidence: 46%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Efficacy of Chondroitin Sulfate for Painful Knee Osteoarthritis: A One-Year, Randomized, Double-Blind, Multicenter Clinical Study in Japan

Morita

Yamada

Date

et al. 2018

Biological & Pharmaceutical Bulletin

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“…It has been suggested to restore the extracellular matrix of cartilage, reducing degradation in OA, and provide sulphur-containing amino acids that are essential for the cartilage extra-cellular matrix, which may be deficient from regular diets [24,25]. A systematic review of chondroitin found that chondroitin had small to moderate effects on pain and physical function in patients with OA, which were clinically significant [26]. It also noted the lower risk of adverse events in patients taking chondroitin supplementation.…”

Section: Chondroitinmentioning

confidence: 99%

Modern Non-Pharmacological and Non-Surgical Treatments for Hip Pain

Lee¹,

Rozewicz²,

Chandrappa³

et al. 2018

J Arthritis

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Osteoarthritis of the hip describes a clinical syndrome of joint pain accompanied by varying degrees of functional limitation and reduced quality of life. Osteoarthritis may not be progressive and most patients will not need surgery, with their symptoms adequately controlled by non-surgical measures. The treatment of hip osteoarthritis is aimed at reducing pain and stiffness and improving joint mobility. Total hip replacement remains the most effective treatment option but it is a major surgery with potential serious complications. NICE guideline has suggested a holistic approach to management of hip osteoarthritis which includes both nonpharmacological and pharmacological treatments. The non-pharmacological treatments range from education ,physical therapy and behavioral changes ,walking aids .The ESCAPE( Enabling Self-Management and Coping of Arthritic Pain Through Exercise) rehabilitation programme for hip and knee osteoarthritis which integrates simple education, self-management and coping strategies, with an exercise regimen has shown to be more cost-effective than usual care. There is a choice of reviewed pharmacological treatments available, but there are few current reviews of possible nonpharmacological methods. This review will focus on the non-pharmacological and non-surgical methods.

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“…Prema rezultatima Kohranove analize randomizovanih kliničkih studija, kratkotrajna primena hondroitin-sulfata (< 6 meseci), pojedinačno ili u kombinaciji sa glukozaminom, bezbedna je i ima blagi do umereno izraženi efekat na simptome bola i suženje zglobnog prostora kod OA kolena. Međutim, neophodan je veći broj kvalitetno dizajniranih kliničkih ispitivanja kako bi se utvrdio klinički značaj suplementacije hondroitin-sulfatom (52). U pogledu strukturno-modifikujućih efekata, nedavna studija Pelletier i sar., pokazala je da je primena hondroitin-sulfata (1200 mg/dan) tokom 24 meseca, efikasnija u odnosu na celokoksib u pogledu usporavanja gubitka artikularne hrskavice kolena, praćeno kvantitativnom magnetnom rezonancom (qMRI) (53).…”

Section: Hondroitin-sulfatunclassified

Nutrition and dietary supplements in the prevention of osteoarthritis

Vidović¹,

Djordjević²

2016

Arh farmaciju

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Optimalna ishrana u cilju održavanja idealne telesne mase uz odgovarajuću fizičku aktivnost ima značajnu ulogu u prevenciji degenerativnih oboljenja zglobova. Klinička ispitivanja su pokazala da gubitak povećane telesne mase smanjuje simptome i poboljšava kvalitet života pacijenata sa osteoartritisom (OA). Takođe, sve je veće interesovanje o uticaju pojedinih nutrijenata, posebno polinezasićenih masnih kiselina i vitamina D, kao i brojnih nenutritivnih biološki aktivnih sastojaka, na strukturna i funkcionalna oštećenja zglobova, kao i kontrolu bola kod OA. Najčešći sastojci dijetetskih suplemenata sa potencijalnim hondroprotektivnim delovanjem su: glukozamin, hondroitin-sulfat, S-adenozilmetionin, metilsulfonilmetan i dr, pojedinačno ili u kombinaciji. Međutim, ograničeni broj adekvatno dizajniranih randomizovanih kontrolisanih ispitivanja potvrdio je njihove simptomatske i strukturno modifikujuće efekte.

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Chondroitin for osteoarthritis

Cited by 181 publications

References 91 publications

Efficacy of Chondroitin Sulfate for Painful Knee Osteoarthritis: A One-Year, Randomized, Double-Blind, Multicenter Clinical Study in Japan

Efficacy of Chondroitin Sulfate for Painful Knee Osteoarthritis: A One-Year, Randomized, Double-Blind, Multicenter Clinical Study in Japan

Modern Non-Pharmacological and Non-Surgical Treatments for Hip Pain

Nutrition and dietary supplements in the prevention of osteoarthritis

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