Chondroitin sulfate-hybridized zein nanoparticles for tumor-targeted delivery of docetaxel

Lee, Han Sol; Kang, Nae‐Won; Kim, Hyelim; Kim, Dong Hyun; Chae, Jung-Woo; Lee, Wonhwa; Song, Gyu Yong; Cho, Cheong-Weon; Kim, Dae‐Duk; Lee, Jae-Young

doi:10.1016/j.carbpol.2020.117187

Cited by 51 publications

(41 citation statements)

References 63 publications

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“…Lee et al . designed a chondroitin sulfate A and MAL-based nanostructure which enhanced tumor targeting and penetration due to selective CD44 receptor binding and selective binding of MAL to the thiol group of blood components and cellular membrane ( Lee H. et al, 2020 ). Huang et al had successfully delivered a polyphenol extract of green tea epigallocatechin-3-gallate (EGCG) by HA-PEG-gelatin NPs to inhibit MMP associated with tumor metastasis and invasion against prostate cancer.…”

Section: Cd44 Engineered Nanocarriers For Cancer Therapymentioning

confidence: 99%

CD44-Targeted Nanocarrier for Cancer Therapy

et al. 2022

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Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in varieties of solid tumors including pancreatic, breast, ovary, brain, and lung cancers. It is a multi-structural glycoprotein of the cell surface which is majorly involved in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and generation of immune responses. Numerous studies focus on the development of nanocarriers for active targeting of the CD44 receptor to improve efficacy of targeting chemotherapy and achieve precise chemotherapy by defining the release, uptake, and accumulation of therapeutic agents. The CD44 receptor has a selective binding affinity towards hyaluronic and chondroitin sulfate (CS). Taking this into consideration, this review focused on the role of CD44 in cancer and its therapy using several nanocarriers such as polymeric/non-polymeric nanoparticles, dendrimer, micelles, carbon nanotubes, nanogels, nanoemulsions etc., for targeted delivery of several chemotherapeutic molecules and nucleic acid. This review also illuminates the role of hyaluronic acid (HA) in cancer therapy, interaction of HA with CD44, and various approaches to target CD44-overexpressed neoplastic cells.

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Section: Cd44 Engineered Nanocarriers For Cancer Therapymentioning

confidence: 99%

CD44-Targeted Nanocarrier for Cancer Therapy

et al. 2022

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“…The LAS technique has been used to process different materials with anti-inflammatory, chemotherapeutic, and antioxidant properties. In some cases, the in vitro cytotoxicity of the processed NPs against cancer cells was evaluated with encouraging results [ 44 , 46 , 62 , 68 , 70 , 85 , 93 , 99 , 102 ]. Moreover, in vivo studies on rats [ 74 , 92 , 95 ] or on human volunteers [ 97 ] were performed in some cases.…”

Section: Microparticles and Nanoparticles Productionmentioning

confidence: 99%

Zein Microparticles and Nanoparticles as Drug Delivery Systems

Marco

2022

Polymers

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Zein is a natural, biocompatible, and biodegradable polymer widely used in the pharmaceutical, biomedical, and packaging fields because of its low water vapor permeability, antibacterial activity, and hydrophobicity. It is a vegetal protein extracted from renewable resources (it is the major storage protein from corn). There has been growing attention to producing zein-based drug delivery systems in the recent years. Being a hydrophobic biopolymer, it is used in the controlled and targeted delivery of active principles. This review examines the present-day landscape of zein-based microparticles and nanoparticles, focusing on the different techniques used to obtain particles, the optimization of process parameters, advantages, disadvantages, and final applications.

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“…The spherical shape and the controlled release of the system indicated its potential applicability in systemic drug delivery. Recently, H. S. Lee et al [ 65 ] developed chondroitin sulfate/zein hybridized nanoparticles for the targeted delivery of docetaxel. The nanoparticles exhibited a CD44 mediated uptake in PC-3 prostate cancer cells and about a 2.8-fold reduction in the IC 50 of docetaxel compared to the free compound.…”

Section: Zein Nanocomposite-based Systemsmentioning

confidence: 99%

Surface-Tailored Zein Nanoparticles: Strategies and Applications

et al. 2021

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Plant-derived proteins have emerged as leading candidates in several drug and food delivery applications in diverse pharmaceutical designs. Zein is considered one of the primary plant proteins obtained from maize, and is well known for its biocompatibility and safety in biomedical fields. The ability of zein to carry various pharmaceutically active substances (PAS) position it as a valuable contender for several in vitro and in vivo applications. The unique structure and possibility of surface covering with distinct coating shells or even surface chemical modifications have enabled zein utilization in active targeted and site-specific drug delivery. This work summarizes up-to-date studies on zein formulation technology based on its structural features. Additionally, the multiple applications of zein, including drug delivery, cellular imaging, and tissue engineering, are discussed with a focus on zein-based active targeted delivery systems and antigenic response to its potential in vivo applicability.

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Chondroitin sulfate-hybridized zein nanoparticles for tumor-targeted delivery of docetaxel

Cited by 51 publications

References 63 publications

CD44-Targeted Nanocarrier for Cancer Therapy

CD44-Targeted Nanocarrier for Cancer Therapy

Zein Microparticles and Nanoparticles as Drug Delivery Systems

Surface-Tailored Zein Nanoparticles: Strategies and Applications

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