Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaeli Debx against severe-stage osteoarthritis model induced by mono-iodoacetate

Eucommia ulmoides Oliv. bark aqueous extract inhibits osteoarthritis in a rat model of osteoarthritis

“…Therefore, a safe and effective anti-osteoarthritis agent is urgently demanded. Traditional Chinese herbal medicines which contain a large number of active compounds could provide a choice for this kind of agent (Ho et al, 2013;Tong et al, 2014).…”

Chrysin protects human osteoarthritis chondrocytes by inhibiting inflammatory mediator expression via HMGB1 suppression

“…Complementary and alternative medical techniques, including certain traditional Chinese medicines (TCMs), including paeonol (25), isofraxidin (26) and Jingui external lotion (27), have been widely used for treating OA for centuries; these are primarily thought to produce chondroprotective effects and even repair cartilage (28,29). Consequently, there is growing interest in exploring TCMs as potential drugs that may aid in reducing inflammation, protecting cartilage against damage, improving joint function and restoring a patient's activity level (30).…”

Chemical and biological studies of Aconitum pharmaceutical resources

“…Detoxicated Fu Zi (d-Fu Zi) was demonstrated to possess chondroprotective activity on MIA-induced OA model by in vivo preventing the articular degeneration and the reduction of bone density and Mankin score (Tong et al, 2014) and by in vitro promoting the chondrocyte proliferation and inhibiting the MIA-induced chondrocyte damage. A total of 23 compounds were identified in d-Fu Zi, most of which were deduced as the nontoxic derivatives of aconite alkaloids.…”