Chondroprotective Effect of Zerumbone on Monosodium Iodoacetate Induced Osteoarthritis in Rats

Biological and chemical properties of Zingiber zerumbet Smith: a review

“…Chondroprotective activity Al-Saffar et al (2010) revealed curative effect of zerumbone in a dose dependent manner on the osteoarthritic knee joints, reported that oral administration of zerumbone in a dose of 2 ml/kg b. wt. of 0.4% w/v diluted with corn oil for a period of 4 weeks had some chondroprotective effects on the knee osteoarthritis of the Sprague-Dawley rats.…”

Key cell signaling pathways modulated by zerumbone: Role in the prevention and treatment of cancer

“…Zerumbone has been investigated for potential curative effects in chemical-induced osteoarthritis in animal models. For instance, oral administration of zerumbone at a dose of 2 mL/kg for a period of 4 weeks produced chondroprotective effects in monosodium iodoacetate (MIA)-induced knee osteoarthritis in Sprague Dawley rats [81]. Zerumbone was also found to improve immunoreactivity of neuropeptides in MIA-induced knee osteoarthritis models [82].…”

A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis

“…Chondrocyte in the mature articular cartilage is the only type of cell that is capable of production and maintenance of the extracellular matrix. Therefore any reduction in chondrocyte density will contribute to the development of OA [5]. To date, there is no effective pharmacological treatment for OA and the end stage of disease usually requires joint replacement surgery [6, 7].…”