Chondroradionecrosis of larynx following radiotherapy for metastatic neck disease originating from oral carcinoma

Bekiroglu, F.; Wright, Sylvia; Grew, N.

doi:10.1016/j.ijom.2006.10.010

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…Irradiation of the neck region can be performed in the presence of neck lymph node metastasis from the larynx, or cancers of any other region, or in the various stages of laryngeal cancer. 2 Apart from the therapeutic nature of radiotherapy, it also has definite hazardous effects on the surrounding tissues and these effects can occur at either early or late stages. Dry mouth, mucositis, Soft Tissue Radionecrosis (STRN), Osteoradionecrosis (ORN), and Laryngeal Radionecrosis (LRN) are some of the examples of these side effects.…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues

Arıcıgil

Dündar

Yücel³

et al. 2018

Brazilian Journal of Otorhinolaryngology

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Section: Introductionmentioning

confidence: 99%

“…Dry mouth, mucositis, Soft Tissue Radionecrosis (STRN), Osteoradionecrosis (ORN), and Laryngeal Radionecrosis (LRN) are some of the examples of these side effects. 2 , 3 …”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues

Arıcıgil

Dündar

Yücel³

et al. 2018

Brazilian Journal of Otorhinolaryngology

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“…Antibiotics and steroids are often the medical regime of choice; however, there is little evidence to support their use. A total of 74 cases of LCRN have been identified in the literature and are summarised in Table 3 6,9,12,13,15,16,18,22–35 . Of the 74 patients, four were initially managed by total laryngectomy.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 74 cases of LCRN have been identified in the literature and are summarised in Table 3. 6,9,12,13,15,16,18,[22][23][24][25][26][27][28][29][30][31][32][33][34][35] Of the 74 patients, four were initially managed by total laryngectomy. Of the remaining 70, 48 (68.6%) improved from treatment ranging from antibiotic therapy to HBOT and cartilage resection.…”

Section: Discussionmentioning

confidence: 99%

Management of laryngeal chondroradionecrosis with pentoxifylline and vitamin E: A case report and review of the literature

2021

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Laryngeal chondroradionecrosis (LCRN) is a rare complication characterised by radiation-induced fibro-atrophy and necrosis of the laryngeal cartilage. There is a mixed consensus on treatment strategy with limited cases reported in the literature. A 60-year-old female patient with a history of a poorly differentiated T3N0M0 glottic laryngeal squamous cell carcinoma treated via chemo-radiotherapy presented 18 months following treatment with discomfort of her throat and difficulty swallowing. Imaging showed fracture of the right lamina of the thyroid cartilage with accompanying soft tissue swelling representative of LCRN. A combination of pentoxifylline and tocopherol (vitamin E) (PENTO) was prescribed on the principle of managing radiation induced fibrosis. At the 1-month review, the patient's throat pain had resolved and her swallowing had improved. A further 2 months later a nasoendoscopy showed no evidence of LCRN. The PENTO protocol has been a successful management strategy in this case in the medium term.

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“…For the management of head and neck cancers, radiotherapy is preferred as a primary or adjuvant treatment modality. RT of the neck may be accomplished in the occurrence of metastatic lymph node from the larynx, or of any other cancers, or in the different stages of cancer of the larynx [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Hyperbaric oxygen therapy in the treatment of complications of irradiation in laryngeal cancer

Uslu¹,

Cebi²,

Çobanoğlu

2018

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One of the standard treatments in laryngeal cancer is radiotherapy (RT). Many short- and long-term complications can occur in the region that has received radiotherapy. Definitive treatment of the emerging complications is still debatable, and treatment is challenging for radiation oncologists and ear nose throat specialists. Recently, hyperbaric oxygen treatment (HBOT) has become a promising alternative for the treatment of these complications. The aim of this report is to discuss the effectiveness of HBOT in the treatment of late-term RT-related potential complications in a patient with laryngeal cancer.We applied HBOT for a 58-year-old male patient with laryngeal cancer for the treatment of laryngeal oedema, and dyspnoea that developed one year after RT. In a decompression chamber at 2.4 atm pressure, the patient was made to breath 100% oxygen with a mask for 90 minutes. At the beginning, HBOT was planned for 30 days; however, it was terminated upon improvement of the symptoms at the 19th session. The symptoms, which developed one year after RT, were relieved completely with HBOT, and the patient is maintaining his life without any complaint under our control.The HBOT can be an alternative treatment for late-term complications developed after radiotherapy. It can be especially used for laryngeal oedema, and dyspnoea related to the field of radiotherapy.

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Chondroradionecrosis of larynx following radiotherapy for metastatic neck disease originating from oral carcinoma

Cited by 5 publications

References 8 publications

Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues

Anti-inflammatory effects of hyperbaric oxygen on irradiated laryngeal tissues

Management of laryngeal chondroradionecrosis with pentoxifylline and vitamin E: A case report and review of the literature

Hyperbaric oxygen therapy in the treatment of complications of irradiation in laryngeal cancer

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