Chondrosarcoma Metastasis to the Choroid

Kim, Jenna M; Wong, Amanda; Lu, Amanda; Pointdujour-Lim, Renelle

doi:10.1159/000494979

Cited by 4 publications

(5 citation statements)

References 13 publications

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“… 9 Interestingly, the fundus imaging and presentation of our patient resembles a chondrosarcoma choroidal metastasis case, with both patients presenting with a large, single, nodular, amelanotic lesion, with associated subretinal fluid. 10 This points to possible common features shared by bone sarcomas metastasizing to the eye.…”

Section: Discussionmentioning

confidence: 97%

Multimodal evaluation of osteosarcoma choroidal metastasis

Mancebo

Inga

Varela

2022

European Journal of Ophthalmology

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Background Osteosarcoma (OS) is the most common primary bone carcinoma. Adulthood most frequent intraocular malignant tumor is choroidal metastasis; however, these are rarely related to sarcomas. There are only two OS-related choroidal metastasis cases reported in the literature, both prior to 1970. Case presentation A 20-year-old man with a history of tibial OS, right leg amputation, and lung and brain metastases, presented with decreased vision in his right eye (OD). Ophthalmic examination revealed a best-corrected visual acuity of hand movements and a large, posterior pole, nodular, subretinal mass, with associated fluid. B-scan revealed a heterogeneous lump, with medium/high reflectivity, and a height-to-base ratio (HBR) of 1-1.2, approximately. Computerized tomography (CT) scan showed a hyperdense and contrast-enhanced mass, while on magnetic resonance imaging (MRI) the lesion appeared T1-isointense and T2-hypointense. Conclusion Choroidal OS metastasis can appear as a pink nodule with high HBR and intralesional hyperreflective deposits. Sudden visual changes in individuals with OS-related systemic metastatic disease should be monitored closely by ophthalmology and oncology jointly.

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Section: Discussionmentioning

confidence: 97%

Multimodal evaluation of osteosarcoma choroidal metastasis

Mancebo

Inga

Varela

2022

European Journal of Ophthalmology

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“…Indeed, cases of metastasis to the testis, thyroid and choroid have been well described. 11,12,13 Gastric neoplasms are almost entirely primary tumors, mainly represented by gastric adenocarcinomas. 14 However, rare cases of secondary gastric neoplasms are described in the literature, most of them of the breast, lung, renal cell cancer, and melanoma.…”

Section: Alphamentioning

confidence: 99%

Chondrosarcoma metastasis simulating a primary stomach tumor: a case report

Gurgel¹,

Nunes²,

Macêdo³

et al. 2023

Brazilian Journal of Oncology

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Gastric tumors are an important cause of cancer deaths. The main type is the primary gastric adenocarcinoma, and rarely secondary metastatic implants can be present. A 79-years-old woman sought medical attention due to a complaint of epigastralgia, unintentional weight loss, two cases of melena in the past two months, and a prior history of a chondrosarcoma of the thigh treated 13 years before. A neoplastic lesion was detected at the stomach during evaluation, and a gastrectomy was opted as a treatment. The immunohistochemical evaluation was compatible with a chondrosarcoma metastatic implant on the stomach. The patient obtained a survival superior to 5 years after surgery. Only one case of gastric metastasis from chondrosarcoma was described in the literature. We observed a great benefit in the use of surgical resection of the gastric lesion, showing that surgery may be considered in selected individuals with chondrosarcoma metastasis.

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“…The course and prognosis of this disease varies widely depending on the tumor grade and type. Metastasis is primarily to the lungs but has been documented to other bones and rarely other sites such as the skin and the eye 2–4 . The primary treatment in humans has been surgical removal of the tumor 5,6 .…”

Section: Introductionmentioning

confidence: 99%

“…Metastasis is primarily to the lungs but has been documented to other bones and rarely other sites such as the skin and the eye. [2][3][4] The primary treatment in humans has been surgical removal of the tumor. 5,6 Local recurrence rate varies but seems to be around 33% 7 and often necessitates further surgery, though its effect on overall prognosis is unclear.…”

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confidence: 99%