Chondrosarcoma of the maxilla: A case report and review of literature

Mahajan, Aarti; Ganvir, SM; Hazarey, Vinay K.; Mahajan, Mahendra C

doi:10.4103/0973-029x.119759

Cited by 24 publications

(21 citation statements)

References 7 publications

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“…Solitary or multiple radiolucencies with ill-defined borders, bone destruction associated with calcifications, ground-glass or sun-ray/sun-burst appearance, and uniform widening of the PDL may occasionally be present 27. In tooth-bearing areas, a widened PDL (a Garrington sign) may be noticed as an early sign of chondrosarcoma 28. If the lesion occurs near the teeth, tooth displacement and root resorption may also be seen 4…”

Section: Resultsmentioning

confidence: 99%

Review of common conditions associated with periodontal ligament widening

Mortazavi

Baharvand

2016

Imaging Sci Dent

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PurposeThe aim of this article is to review a group of lesions associated with periodontal ligament (PDL) widening.Materials and MethodsAn electronic search was performed using specialized databases such as Google Scholar, PubMed, PubMed Central, Science Direct, and Scopus to find relevant studies by using keywords such as “periodontium”, “periodontal ligament”, “periodontal ligament space”, “widened periodontal ligament”, and “periodontal ligament widening”.ResultsOut of nearly 200 articles, about 60 were broadly relevant to the topic. Ultimately, 47 articles closely related to the topic of interest were reviewed. When the relevant data were compiled, the following 10 entities were identified: occlusal/orthodontic trauma, periodontal disease/periodontitis, pulpo-periapical lesions, osteosarcoma, chondrosarcoma, non-Hodgkin lymphoma, progressive systemic sclerosis, radiation-induced bone defect, bisphosphonate-related osteonecrosis, and osteomyelitis.ConclusionAlthough PDL widening may be encountered by many dentists during their routine daily procedures, the clinician should consider some serious related conditions as well.

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Section: Resultsmentioning

confidence: 99%

Review of common conditions associated with periodontal ligament widening

Mortazavi

Baharvand

2016

Imaging Sci Dent

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“…The five year survival rate ranges from 44-87.5% but lifelong follow up is necessary as it can show recurrence or metastasis even after two decades [4]. Prognostic indicators are the size, location, grade and surgical respectability of the tumour [13]. Traditionally considered to be radioresistant, radiotherapy may be indicated for unresectable tumours or as adjuvant therapy for incompletely resected tumours [4].…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated Chondrosarcoma of Temporomandibular Joint: Atypical Features of a Rare Case

Rath

Das

Baisakh

et al. 2014

JCDR

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A 55-year-male patient visited our dental outpatient department with a complaint of pain and progressive swelling on right side of the face since six months. Extra oral examination revealed a diffuse preauricular swelling measuring about 5x3 cm. On palpation it was firm, tender, diffuse and fixed to underlying structures. Right submandibular nodes were palpable, non tender and mobile. There was restricted mouth opening with 18mm of inter incisal distance with spontaneous deviation of the jaw to affected side on opening the mouth [Table /Fig-1a,b]. There was no history of recent or past trauma to the area. Clinically, the provisional diagnosis included chronic inflammation or tumour of the TMJ, fracture of the condyle, sialadenitis or tumour of the parotid gland. However, the salivary duct opening and salivary flow were normal.Coronal and axial CT scan revealed an ill defined osseous outgrowth arising from right condyle of mandible showing bony destruction and deformity with soft tissue component and islands of amorphous calcification. The cortex of the lesion was seen destroyed, continuous with that of underlying bone from which it arose and the trabecular pattern was seen merging into the medullary cavity [Table/ Fig-2a,b]. The lesion involved the right infratemporal fossa, masticator space and eroded the posterior wall of the maxillary sinus. Such findings of a destructive lytic lesion that too of a short duration favored an underlying malignant process like osteosarcoma, chondrosarcoma or any metastatic tumour of TMJ. Fine needle aspiration cytology of the mass was performed which was non contributory. An incisional biopsy revealed neoplastic chondrocytes in lacunar spaces present in a chondroid matrix, exhibiting pleomorphic and hyper chromatic nucleus. A diagnosis of chondrosarcoma (CS) was made but possibility of chondroblastic osteosarcoma was kept in mind as it was a small biopsy specimen. Investigations like chest radiographs, ultrasound of neck and abdomen and CT of neck were done to rule out metastasis. Segmental resection of ramus was done along with excision of tumour mass that measured about 10 x7 cm. The condyle was resorbed and cut surface of tumour was whitish opaque, peripherally slightly mucoid and with central foci of calcifications [Table /Fig-3a,b]. Microscopically the sections showed typical low grade cartilaginous matrix and pleomorphic chondrocytes in large lacuna with hyperchromatic nuclei and open chromatin pattern, arranged in a lobular configuration. This sharply contrasted the adjacent foci made of pleomorphic spindle cells in storiform pattern Fig-4a,b]. There were foci of enchondral ossification. No presence of tumour osteoid could be discerned in multiple, serial sections. A final diagnosis of dedifferentiated chondrosarcoma of right TMJ was made. The surgical margins of resected specimen were free of tumour infiltration. On advice of the medical oncologist, the patient received radiotherapy one month post-operatively and remained in a one year disease free follow-up.

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“…The main affected sites are the sphenoid and maxillary sinus [13]. Overall survival after 5 years is estimated at 80.7% [14], depending on size, localization and grade [15]. The metastasis rate is higher in primary and dedifferentiated chondrosarcomas than in secondary ones [16].…”

Section: Case Presentationmentioning

confidence: 99%

“…Patients with Maffucci syndrome have a 25% to 30% risk of developing chondrosarcomas and are usually younger than those with primary chondrosarcoma [15]. The chondrosarcomas usually present at the upper and lower extremities.…”

Section: Case Presentationmentioning

confidence: 99%

Chondrosarcoma of the nasal cavity in a patient with Maffucci syndrome: case report and review of the literature

et al. 2014

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IntroductionMaffucci syndrome is a rare, congenital, non-hereditary mesodermal dysplasia, manifested by multiple enchondromas and hemangiomas. Malignant transformation of these lesions is seen in up to 40% of the cases.Case reportWe present a case of a patient with Maffucci syndrome and an associated chondrosarcoma of the nose. Treatment consisted of surgical resection. Because of the low grade of the tumor, additional treatment, such as radiotherapy, was not necessary.ConclusionMaffucci syndrome is an exceedingly rare mesodermal dysplasia. Its manifestation in the head and neck region is even less common. Malignant transformation of the associated enchondromas is common, and should be considered whenever a change of the clinical course occurs. Random, periodically performed X-ray examinations give little additional information on malignant transformation and are considered useless.

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Chondrosarcoma of the maxilla: A case report and review of literature

Cited by 24 publications

References 7 publications

Review of common conditions associated with periodontal ligament widening

Review of common conditions associated with periodontal ligament widening

Dedifferentiated Chondrosarcoma of Temporomandibular Joint: Atypical Features of a Rare Case

Chondrosarcoma of the nasal cavity in a patient with Maffucci syndrome: case report and review of the literature

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