Chondrosarcoma secondary to synovial chondromatosis

Wuisman, P.; Noorda, R. J. P.; Jutte, Paul C.

doi:10.1007/bf00390060

Cited by 56 publications

(21 citation statements)

References 17 publications

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“…From a radiological point of view a permeated and destructive pattern rather than an erosive one is suspicious for malignancy (25). In contrast, Wittkop et al did not observe any MRI features to distinguish the malignant changes of a SC (30).…”

Section: Resultsmentioning

confidence: 94%

Synovial chondrosarcoma

Biazzo¹,

Confalonieri²

2016

Ann. Transl. Med.

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Background: Synovial chondrosarcoma (SCH) is a very rare tumor arising in the intra-articular cavity. In the majority of literature reports it is described as a malignant transformation of a pre-existing synovial chondromatosis (SC). We reported a systematic review of primary and secondary SCH described in the literature with the aim to recollect data from different case-reports and case-series, trying to summarize general aspects of this very rare disease. Methods:We collected 42 abstracts in the form of case series and case reports, which reported 67 cases of SCH.Studies were taken into account only if they proved a histological diagnosis of SCH, either primary or secondary, with or without evidence of pre-existing SC.Results: The average age of SCH was 56.9 years, with prevalence for male sex. The average time of malignant transformation was 11.2 years. The most affected joint was the knee (47.7%), followed by hip (34.3%) and ankle (5.9%). SCH was described as de novo sarcoma only in 13 cases (19%). Surgery ended up with amputation in 59.7% of cases. Local recurrence rate was 28.3%. Conclusions:We concluded that prognosis of SCH is worse than conventional one and we speculated this is due to the difficult site of the tumor (intraarticular), diagnostic delay and inappropriate previous treatments. We consider that a rapid deterioration of a SC or rapid recurrence after synoviectomy should be considered suspicious of malignant transformation and should be treated in a reference center.

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Section: Resultsmentioning

confidence: 94%

Synovial chondrosarcoma

Biazzo¹,

Confalonieri²

2016

Ann. Transl. Med.

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“…The clinical features alone are not helpful for distinguishing them, and no definite imaging criteria can differentiate synovial chondromatosis from low-grade synovial chondrosarcoma (2)(3)(4)(5). Synovial chondromatosis is very difficult to distinguish from secondary synovial chondrosarcoma solely on clinical, radiological or histological criteria.…”

mentioning

confidence: 99%

Synovial chondrosarcoma arising from synovial chondromatosis of the knee

Yao

Chang

Chen

et al. 2012

Journal of the Belgian Society of Radiology

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“…In the secondary SC, the loose bodies are within the joint and have the potential for slow growth by synovial metaplasia following proliferation of surrounding connective tissue (Milgram 1977, Villacin et al 1979, Saotome et al 1999. Exceptional cases with a transformation from SC to chondrosarcoma have been described (Kaiser et al 1980, Perry et al 1988, Bertoni et al 1991, Kenan et al 1993, Hermann et al 1997, Wuisman et al 1997, Wittkop et al 2002, Ko et al 2004.…”

Section: Discussionmentioning

confidence: 99%