Chondrotoxic effects of intra-articular injection of local anaesthetics in the rabbit temporomandibular joint

Asan, Canay Yılmaz; Ağyüz, G; Canpolat, Dilek Günay; Demirbaş, Ahmet Emin; Asan, M; Yay, Arzu Hanım; Ülger, Menekşe; Karakükçü, Çiğdem

doi:10.1016/j.ijom.2022.01.011

Cited by 7 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While information is still limited concerning the damaging effects on the cartilage in IA injections for the hip, the chondrotoxicity of local anesthetics utilized in these injections has also been suggested [ 6 - 8 ]. This could potentially lead to cellular demise and structural alterations in the articular cartilage, leading to osteonecrosis and/or collapse of the bone matrix.…”

Section: Discussionmentioning

confidence: 99%

“…This could potentially lead to cellular demise and structural alterations in the articular cartilage, leading to osteonecrosis and/or collapse of the bone matrix. Research suggests that their application could induce cell death and structural changes in the articular cartilage in a matter of weeks [ 8 ]. Recent in vitro research by Mwale et al in 2023 found that bupivacaine, levobupivacaine, and ropivacaine triggered apoptosis, as indicated by increased caspase-3 activity, within 24 h of induction of the drug [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid Osteoarthritis and Femoral Head Collapse: A Case Series

Rana,

Johnson,

Turcotte

et al. 2024

jocr

View full text Add to dashboard Cite

Introduction: Rapidly progressive hip osteoarthritis (OA) leading to femoral head collapse (FHC) following intra-articular (IA) corticosteroid injections is a perplexing variant of OA. We explored eight cases of chronic joint pain treated with IA corticosteroid injections. Subsequently, they experienced swift deterioration of the femoral head integrity within as little as 10 weeks. These cases underscore the need for a comprehensive assessment of risk factors versus benefits in this patient population. Case Report: The study reveals a complex interplay between comorbidities, treatments, and outcomes. Patients exhibited various health factors, including obesity, smoking history, cancer treatment, and deficiencies in Vitamin D levels, which have been found to increase the risk of FHC. Furthermore, the study explores the chondrotoxicity of corticosteroids and local anesthetics used in IA injections. In vitro studies show complete loss of chondrocyte viability after a single dose of corticosteroids, potentially leading to cartilage degradation. In addition, local anesthetics may induce cellular demise and structural alterations in the articular cartilage. These factors highlight various influences affecting treatment outcomes in patients with OA. Conclusion: In conclusion, this case series highlights the rare adverse outcome of rapidly progressive hip OA and FHC following IA corticosteroid injections and possible risk factors. While a definitive etiology remains unclear, the study provides valuable conclusions to aid in future treatment decision-making. Keywords: Rapidly progressive hip osteoarthritis, intra-articular injections, corticosteroid injections, femoral head collapse.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Rapid Osteoarthritis and Femoral Head Collapse: A Case Series

Rana,

Johnson,

Turcotte

et al. 2024

jocr

View full text Add to dashboard Cite

show abstract

“…The selection process inadvertently identified one experimental study on the administration of local anesthetics to the temporomandibular joint cavities. In a 2022 report by Asan et al, cytotoxicity of administration of 1 mL of lidocaine, bupivacaine, or articaine into the cavities of rabbit temporomandibular joints was indicated [ 69 ]. In the post-mortem examination, thinning and unevenness of articular cartilage and a reduced amount of collagen were observed compared to the placebo group receiving physiological saline solution.…”

Section: Discussionmentioning

confidence: 99%

Intra-Articular Local Anesthetics in Temporomandibular Disorders: A Systematic Review and Meta-Analysis

Lubecka,

Chęcińska,

Bliźniak

et al. 2023

JCM

View full text Add to dashboard Cite

This systematic review with meta-analysis was conducted to evaluate the effectiveness of local anesthetic administration into temporomandibular joint cavities in relieving pain and increasing mandibular mobility. Randomized controlled trials were included with no limitation on report publication dates. Final searches were performed on 15 October 2023, using engines provided by the US National Library, Bielefeld University, and Elsevier Publishing House. The risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Articular pain and mandible abduction values and their mean differences were summarized in tables and graphs. Eight studies on a total of 252 patients evaluating intra-articular administration of articaine, bupivacaine, lidocaine, and mepivacaine were included in the systematic review. None of the eligible studies presented a high risk of bias in any of the assessed domains. An analgesic effect of intra-articular bupivacaine was observed for up to 24 h. In the long-term follow-up, there were no statistically significant changes in quantified pain compared to both the baseline value and the placebo group, regardless of the anesthetic used (articaine, bupivacaine, and lidocaine). There is no scientific evidence on the effect of intra-articular administration of local anesthesia on the range of motion of the mandible. Therefore, in the current state of knowledge, the administration of local anesthetics into the temporomandibular joint cavities can only be considered as a short-term pain relief measure.

show abstract

SSR white paper: guidelines for utilization and performance of direct MR arthrography

Chang,

Bencardino,

French

et al. 2023

Skeletal Radiol

View full text Add to dashboard Cite

Objective Direct magnetic resonance arthrography (dMRA) is often considered the most accurate imaging modality for the evaluation of intra-articular structures, but utilization and performance vary widely without consensus. The purpose of this white paper is to develop consensus recommendations on behalf of the Society of Skeletal Radiology (SSR) based on published literature and expert opinion. Materials and methods The Standards and Guidelines Committee of the SSR identified guidelines for utilization and performance of dMRA as an important topic for study and invited all SSR members with expertise and interest to volunteer for the white paper panel. This panel was tasked with determining an outline, reviewing the relevant literature, preparing a written document summarizing the issues and controversies, and providing recommendations. Results Twelve SSR members with expertise in dMRA formed the ad hoc white paper authorship committee. The published literature on dMRA was reviewed and summarized, focusing on clinical indications, technical considerations, safety, imaging protocols, complications, controversies, and gaps in knowledge. Recommendations for the utilization and performance of dMRA in the shoulder, elbow, wrist, hip, knee, and ankle/foot regions were developed in group consensus. Conclusion Although direct MR arthrography has been previously used for a wide variety of clinical indications, the authorship panel recommends more selective application of this minimally invasive procedure. At present, direct MR arthrography remains an important procedure in the armamentarium of the musculoskeletal radiologist and is especially valuable when conventional MRI is indeterminant or results are discrepant with clinical evaluation.

show abstract

Chondrotoxic effects of intra-articular injection of local anaesthetics in the rabbit temporomandibular joint

Cited by 7 publications

References 31 publications

Rapid Osteoarthritis and Femoral Head Collapse: A Case Series

Rapid Osteoarthritis and Femoral Head Collapse: A Case Series

Intra-Articular Local Anesthetics in Temporomandibular Disorders: A Systematic Review and Meta-Analysis

SSR white paper: guidelines for utilization and performance of direct MR arthrography

Contact Info

Product

Resources

About