BackgroundVery low‐calorie diet (VLCD) programs are readily available in Australia. However, there is a lack of real‐world evidence describing the characteristics related to positive outcomes.AimsTo examine the demographic, eating, self‐efficacy and program engagement characteristics of VLCD users in Australia, and the associations between user characteristics and program success, weight loss, quality of life (QOL) and health.MethodCross‐sectional data from Australian adults; regular users (n=189: VLCD user ≥4 days/week for >4 weeks) and intermittent users (n=111, VLCD user <4 weeks and/or <4 days/week). Self‐reported data on demographics, VLCD program use, support, eating behaviour, weight‐related QOL, mental health, physical health, self‐efficacy, and physical activity. Descriptive and inferential statistics were performed in R.ResultsCompared to regular users, intermittent users reported lower percentage weight loss (15.1%±SD 9.8 vs. 9.9%±SD 6.8, relative to starting weight), fewer reported their VLCD program as very successful (44% vs. 35%), higher depressive symptom scores (8.7±SD 2.8 vs. 6.7±SD 5.1), and lower general self‐efficacy (23.9±SD 4.7 vs. 29.4±SD5.7), nutrition self‐efficacy (11.9± SD 2.0 vs. 14.5± SD 3.1) and weight‐related QOL scores (60.9±SD 22.2 vs. 65.0±SD 11.8; p<0.001 for all). In regular users, older age and longer program duration were associated with greater total weight loss, support, and program success (p<0.001 for all). In intermittent users, program success was greater when dietitian support was used (OR 6.50) and for those with higher BMIs (OR 1.08, p<0.001 for all). In both groups, more frequent support was associated with better weight‐related QOL (p<0.001).ConclusionThis study provides real‐world evidence that regular VLCD users had greater success and weight loss over intermittent program users. Findings may be used to tailor and improve the delivery of VLCD programs in Australia and other countries with retail access to VLCDs.This article is protected by copyright. All rights reserved.