Choosing between the EORTC QLQ-C30 and FACT-G for measuring health-related quality of life in cancer clinical research: issues, evidence and recommendations

Abstract

Where research objectives are concerned with the impact of a specific tumour type, treatment or symptom, choice should be guided by the availability, content, scale structure and psychometric properties of relevant European Organisation for the Research and Treatment of Cancer versus Functional Assessment of Chronic Illness Therapy modules. Because the FACT-G combines symptoms and concerns within each scale, individual items should always be reviewed within the context of specific research objectives. Where these issues are indecisive, researchers are encouraged to use an algorithm at the end of the current article.

Patient-reported Outcome Measures in Radiotherapy: Clinical Advances and Research Opportunities in Measurement for Survivorship

“…SF-36, a generic tool combined with prostate-specific UCLA-PCI for prostate cancer), though this is not always the case. It is worth noting that when multiple tools are used together, they may contain overlapping questions, differences in scaling and these may result in differences in PRO results within the same study (32). Our results were similar to Graff in that it is important to know what you intend to measure, why you want to measure it and be sure the PRO instrument you choose measures what is intended or use tools that include both global and specific PROM concepts.…”

Psychometric Validation of the Malaysian Chinese Version of the EORTC QLQ-C30 in Colorectal Cancer Patients

“…This questionnaire is frequently used in cancer of the colorectum (Hung et al, 2013;Smith et al, 2013). The questionnaire has been validated across many cultures and disease conditions and was found to have adequate acceptable psychometric properties (Schwenk et al, 2004;Huang et al, 2007;Jayasekara et al, 2008;Luckett et al, 2011;Uwer et al, 2011;Yakar and Pinar, 2013). Details of its application, interpretation and reference values for comparison among different groups of patients are readily available (King, 1996;Michelson et al, 2000;Fayers, 2001;Arraras Urdaniz et al, 2008;Finck et al, 2012).…”

Quality of life in patients with K‐RAS wild‐type colorectal cancer

“…The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) is the most frequently used self-administered, cancer-specific QoL questionnaire. 8 It has demonstrated validity and reliability in patients with advanced cancer 9 and has been shown to be responsive to the effects of chemotherapy in patients with CRC. 10 This instrument has 30 items with 5 functional scales (Physical, Role, Cognitive, Emotional, and Social), a GHS scale, 3 symptom scales (Fatigue, Pain, and Nausea and Vomiting) and 6 single items (Dyspnea, Sleep Disturbance, Appetite Loss, Constipation, Diarrhea, and Financial Impact).…”