This multidisciplinary work analyzes the impact of digitalization on civilized humanity, conceived in terms of purposive, goal-directed agency. More particularly, it examines the close collaboration of human and artificial agents as augmented agents, viewing them both as complex, open adaptive systems, which vary dynamically in context. This first chapter explains general metamodels of agentic form and function, where metamodels are defined as families or related sets of models. From this perspective, augmented agency presents a new class of agentic metamodel, for individuals, groups, and collectives. At the same time, however, new risks and dilemmas emerge, which reflect the challenge of combining and supervising different human and artificial capabilities and potentialities. Problems of this kind are a recurrent topic throughout the book.