2024
DOI: 10.3389/fimmu.2024.1375833
|View full text |Cite
|
Sign up to set email alerts
|

Choosing T-cell sources determines CAR-T cell activity in neuroblastoma

Lorena García-García,
Elena G. Sánchez,
Mariya Ivanova
et al.

Abstract: IntroductionThe clinical success of chimeric antigen receptor-modified T cells (CAR-T cells) for hematological malignancies has not been reproduced for solid tumors, partly due to the lack of cancer-type specific antigens. In this work, we used a novel combinatorial approach consisting of a versatile anti-FITC CAR-T effector cells plus an FITC-conjugated neuroblastoma (NB)-targeting linker, an FITC-conjugated monoclonal antibody (Dinutuximab) that recognizes GD2.MethodsWe compared cord blood (CB), and CD45RA-e… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 63 publications
0
0
0
Order By: Relevance