Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice

Correa, Mercè; Pardo, Marta; Bayarri, Pilar; López-Cruz, Laura; Miguel, Noemí San; Valverde, Olga; Ledent, Catherine; Salamone, John D.

doi:10.1007/s00213-015-4127-3

Cited by 57 publications

(65 citation statements)

References 59 publications

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“…The rewarding effects of voluntary wheel running have been found to be associated with neuroplastic changes in the mesolimbic pathway, that include downregulation of dopaminergic D2 receptor mRNA expression in the nucleus accumbens core of rats [20]. Preference for voluntary exercise over sucrose was also found reduced after treatment with the D2 antagonist haloperidol [21]. Furthermore, the D2 antagonist raclopride reduced voluntary wheel running in mice [22] suggesting that sustained stimulation of D2 receptors contributes to the motivation for exercise.…”

Section: Introductionmentioning

confidence: 99%

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice

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Kendall

Pardon

2016

Behavioural Brain Research

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Number of tables: 1Number of words in the abstract: 248Number of words in the manuscript (including tables and figure legends): 6,639Number of words in the introduction: 1,290Number of words in the discussion: 1,243 ABSTRACT Physical exercise can improve cognition but whether this is related to motivation levels is unknown. Voluntary wheel running is a rewarding activity proposed as a model of motivation to exercise. To question the potential effects of exercise motivation on subsequent behaviour, we used a pharmacological approach targeting some reward mechanisms. The stress hormone corticosterone has rewarding effects mediated by activation of low affinity glucocorticoid receptors (GR). To investigate whether corticosterone synthesis motivates exercise via activation of GRs and subsequently, impacts on behaviour, we treated C57BL/6J mice acutely with the inhibitor of corticosterone synthesis metyrapone (35 mg/kg) or repeatedly with the GR antagonist mifepristone (30 mg/kg) prior to 1-hour running wheel sessions. To investigate whether reducing motivation to exercise impacts on behaviour, we antagonised running-induced dopamine D2/D3 receptors activation with sulpiride (25 or 50 mg/kg) and assessed locomotor, anxiety-related and memory performance after 20 running sessions over 4 weeks. We found that corticosterone synthesis contributes to running levels, but the maintenance of running behaviour was not mediated by activation of GRs. Intermittent exercise was not associated with changes in behavioural or cognitive performance. The persistent reduction in exercise levels triggered by sulpiride also had limited impact on behavioural performance, although the level of performance for some behaviours was related to the level of exercise. Altogether, these findings indicate that corticosterone and dopamine D2/D3 receptor activation contribute to the motivation for wheel running, but suggest that motivation for exercise is not a sufficient factor to alter behaviour in healthy mice.

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Section: Introductionmentioning

confidence: 99%

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice

Ebada

Kendall

Pardon

2016

Behavioural Brain Research

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“…Thus, the 3-choice t-maze task, is sensitive to DA manipulations as observed in previous studies (Correa et al, 2016). This type of task is used for the evaluation of .…”

Section: Introductionsupporting

confidence: 55%

“…Time spent in the RW compartment is not reduced, suggesting that although the total time running is lower, maybe the resting times were longer than under BL conditions. Devaluation of RW motivational value by RW pre-exposure, has been tried on a previous study (Correa et al, 2016). However, the parameters used (duration of preexposure) were not enough to induce "satiation", possibly because running in the wheel becames habitual and therefore relatively insensitive to devaluation.…”

Section: Discussionmentioning

confidence: 99%

“…These activational aspects of motivation are highly adaptive, because they enable organisms to overcome the work-related obstacles that separate them from significant stimuli Correa, 2002, 2012). The present studies investigated the impact of TBZ, caffeine and their combination on a novel T-maze task developed to assess preferences between active versus sedentary sources of reinforcement (adapted from Correa et al 2016). This T-maze task does not involve work in order to get access to a reinforcer, as previous tasks developed in our laboratory Yohn et al 2015), but instead offers the choice to freely engage in wheel running, or to consume palatable pellets containing 50% sucrose or, as a third alternative, to sniff into a hole with a neutral non-social odor.…”

Section: Introductionmentioning

confidence: 99%

“…One of the behavioral tests used in present dissertation for the evaluation of anergia-like effects induced by the VMAT2 inhibitor TBZ, is the 3-choice t-maze task (adapted from Correa et al, 2016). In this test animals can chose between running on a wheel (RW) vs.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The effects of adenosine antagonists on distinct aspects of motivated behavior: interaction with ethanol and dopamine depletion

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Sex‐dependent differences in voluntary physical activity

Rosenfeld

2016

J of Neuroscience Research

123

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There are increasing numbers of overweight and obese individuals in the US and globally, and correspondingly, the associated healthcare costs are rising dramatically. More than one-third of children are currently considered obese with a predisposition to type 2 diabetes, and it is likely that their metabolic conditions will worsen with age. Physical inactivity has also risen to be the leading cause of many chronic, non-communicable diseases (NCD). Children are more physically inactive now than they were in past decades, which may be due to intrinsic and extrinsic factors. In rodents, the amount of time engaged in spontaneous activity within the home cage is a strong predictor of later adiposity and weight gain. Thus, it is important to understand primary motivators stimulating physical activity (PA). There are normal sex differences in PA levels in rodents and humans. The perinatal environment can induce sex-dependent differences in PA disturbances. This review will consider the current evidence that there are sex differences in PA in rodents and humans. The rodent studies showing that early exposure to environmental chemicals can shape later adult PA responses will be discussed. Next, an exploration of whether there are different motivators stimulating exercise in male vs. female humans will be examined. Finally, the brain regions, genes, and pathways, that modulate PA in rodents, and possibly by translation humans, will be described. A better understanding of why each sex remains physically active through the lifespan could open up new avenues to prevent and treat obesity in children and adults.

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Choosing voluntary exercise over sucrose consumption depends upon dopamine transmission: effects of haloperidol in wild type and adenosine A2AKO mice

Cited by 57 publications

References 59 publications

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice

Corticosterone and dopamine D2/D3 receptors mediate the motivation for voluntary wheel running in C57BL/6J mice

The effects of adenosine antagonists on distinct aspects of motivated behavior: interaction with ethanol and dopamine depletion

Sex‐dependent differences in voluntary physical activity

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