Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats

Stratford, Jennifer M.; Curtis, Kathleen S.; Contreras, Robert J.

doi:10.1016/j.physbeh.2006.06.009

Cited by 45 publications

(47 citation statements)

References 36 publications

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“…A bilateral CTX induces a decrease in fat preference (157,209) and in conditioned LCFA aversion during behavioral tests in rats (157). A more drastic effect is observed after a total denervation of the peripheral gustatory nerves.…”

Section: Lipid Signal In the Gustatory Circuitrymentioning

confidence: 98%

Taste of Fat: A Sixth Taste Modality?

Besnard

Passilly-Degrace

Khan

2016

Physiological Reviews

203

170

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An attraction for palatable foods rich in lipids is shared by rodents and humans. Over the last decade, the mechanisms responsible for this specific eating behavior have been actively studied, and compelling evidence implicates a taste component in the orosensory detection of dietary lipids [i.e., long-chain fatty acids (LCFA)], in addition to textural, olfactory, and postingestive cues. The interactions between LCFA and specific receptors in taste bud cells (TBC) elicit physiological changes that affect both food intake and digestive functions. After a short overview of the gustatory pathway, this review brings together the key findings consistent with the existence of a sixth taste modality devoted to the perception of lipids. The main steps leading to this new paradigm (i.e., chemoreception of LCFA in TBC, cell signaling cascade, transfer of lipid signals throughout the gustatory nervous pathway, and their physiological consequences) will be critically analyzed. The limitations to this concept will also be discussed in the light of our current knowledge of the sense of taste. Finally, we will analyze the recent literature on obesity-related dysfunctions in the orosensory detection of lipids ("fatty" taste?), in relation to the overconsumption of fat-rich foods and the associated health risks.

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Section: Lipid Signal In the Gustatory Circuitrymentioning

confidence: 98%

Taste of Fat: A Sixth Taste Modality?

Besnard

Passilly-Degrace

Khan

2016

Physiological Reviews

203

170

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“…In short access tests, anosmic and intact rodents prefer oils to xantham gum, which mimics the texture of oil (Takeda et al, 2001;Fukuwatari et al, 2003), and humans can taste long chain free fatty acids even when olfaction is eliminated by using a nose clip and the specific texture of fatty acids is masked by diluting them in viscous solutions (Chale-Rush et al, 2007). Gustatory nerve transection impairs fatty acid detection and/or preference in rats and mice (Stratford et al, 2006;Pittman et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120

Cartoni¹,

Yasumatsu²,

Ohkuri³

et al. 2010

Journal of Neuroscience

357

308

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The oral perception of fat has traditionally been considered to rely mainly on texture and olfaction, but recent findings suggest that taste may also play a role in the detection of long chain fatty acids. The two G-protein coupled receptors GPR40 (Ffar1) and GPR120 are activated by medium and long chain fatty acids. Here we show that GPR120 and GPR40 are expressed in the taste buds, mainly in type II and type I cells, respectively. Compared with wild-type mice, male and female GPR120 knock-out and GPR40 knock-out mice show a diminished preference for linoleic acid and oleic acid, and diminished taste nerve responses to several fatty acids. These results show that GPR40 and GPR120 mediate the taste of fatty acids.

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“…For example, building demonstrated the critical role played by gustatory neurotransmission in fat detection and preference. For example, surgical resection of the chorda tympani (branch of CNVII) or CNIX in rodents decreases both intake of and preference for a high-fat liquid meal (55)(56)(57)(58)(59). Conversely, oral exposure to fat increases the activity of taste-sensitive neurons of the NST (57) and excites forebrain circuits involved in food reward (60,61).…”

Section: Gut Endocannabinoids As Hunger Signalsmentioning

confidence: 99%