Chordoid glioma: an entity occurring not exclusively in the third ventricle

Bao, Yijun; Yang, Chenlong; Du, Jiang; Fang, Jingyi; Li, Guang; Wang, Shuo; Xu, Yulun

doi:10.1007/s10143-019-01161-w

Cited by 13 publications

(17 citation statements)

References 28 publications

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“…4 Its histogenesis remains uncertain and the current hypotheses states a glial origin from the ependymal cells of the lamina terminalis and/or from the multipotent stem cell of Rathke's pouch. 1 It seems that, to date, less than 100 cases of chordoid glioma have been reported, only three cases outside the third ventricle. 1 The clinical picture can vary from being completely asymptomatic to space-occupying general and/or local effect symptoms as headache, visual changes, memory Pathology analysis showed a), b) (both in 100x) and c) (400x) fragments of a partly well-defined neoplasm, composed of cells with a regular nucleus and vast, eosinophilic cytoplasm, organized in cords and trabeculae within a myxoid stroma.…”

Section: Brief Review Of the Literature And Discussionmentioning

confidence: 99%

“…1 It seems that, to date, less than 100 cases of chordoid glioma have been reported, only three cases outside the third ventricle. 1 The clinical picture can vary from being completely asymptomatic to space-occupying general and/or local effect symptoms as headache, visual changes, memory Pathology analysis showed a), b) (both in 100x) and c) (400x) fragments of a partly well-defined neoplasm, composed of cells with a regular nucleus and vast, eosinophilic cytoplasm, organized in cords and trabeculae within a myxoid stroma. There was a moderate lymphoid infiltrate, generally perivascular, with germinal centers, some plasmocytes with Russel bodies and areas of fibrosis.…”

Section: Brief Review Of the Literature And Discussionmentioning

confidence: 99%

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Incidental Third Ventricular Chordoid Glioma: Case Report

Dias¹

2021

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Chordoid glioma is a grade II (World Health Organization) rare type of brain tumor, frequently arising within the anterior part of third ventricle and/or suprasellar region, which can cause symptoms from obstructive hydrocephalus, local compression (as hypothalamic disfunction) or intracranial hypertension.We report an incidental case of 57-years-old woman, scheduled to a neurosurgery appointment due to an infundibular tumor, found on requested image after presenting unusual headaches and facial paresthesia. The tumor was totally resected by microsurgery via right pterional/trans-lamina terminalis approach without any postoperative morbidity. Histological analysis confirmed the unexpected chordoid glioma diagnosis.Chordoid glioma of the third ventricle is a rare tumor, which ideal treatment is surgical gross-total tumor removal. However, as it can carry a high risk of postoperative complications due to its location, one should make a careful and well-planed treatment decision on any case, especially in incidental and/or oligosymptomatic ones.

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Section: Brief Review Of the Literature And Discussionmentioning

confidence: 99%

Section: Brief Review Of the Literature And Discussionmentioning

confidence: 99%

Incidental Third Ventricular Chordoid Glioma: Case Report

Dias¹

2021

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“…They generally arise in the midline and displace normal structures in all directions as they enlarge (2). While there were a few reports that chordoid glioma located outside the third ventricle, such as hemisphere, thalamus, parieto-temporal extra-ventricular, juxtaventricula et al (8). This made the diagnosis di cult and had challenges.…”

Section: Discussionmentioning

confidence: 99%

Chordoid Glioma of the Third Ventricular with Three less Common Patterns and Three Rare Patterns

Ma¹,

zhu

wang

et al. 2020

Preprint

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BackgroundChordoid gliomas are rare, low-grade neoplasms of the third ventricle. In the updated 4th edition of the 2016 WHO classification of tumours of the CNS, it described some three less common histological patterns and rare tissue patterns. Case presentationHere we reported a case with all the uncommon patterns. It was a 52-year-old woman with dizziness and blurred vision. Imaging showed a solid tumor located in the third ventricle with a well-circumscribed border. Histological, almost tumor cells formed into atypical glands with different sizes and irregular shapes in an abundant of solid or loosely collagen matrix. Some tumor cells formed into papillary patterns, micro-papillary patterns. pseudoglandular patterns. Some focal tumor cells were spindle-shape. Only few epithelioid tumor cells formed into clusters and cords embedded into a myxoid stroma like the chordoma. No anaplastic features were identified in any lesion. Immunohistochemically, all the tumor cells were strong reactivity for TTF-1. Some tumor cells strong but focal reactivity for GFAP, NEU-N, and CD34. It showed a recurrent D463H missense mutation in PRKCA. All these findings confirm that the diagnosis was chordoid glioma of the third ventricular. ConclusionsThere may be lots of histopathological features in one chordoid glioma case. It maybe suggested that PRKCA D463H mutation and TTF-1 positive may help to diagnose it.

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Section: Discussionmentioning

confidence: 99%

“…On MRI, the solid portion of tumors showed isointense or hypointensity on T1-weighted and hyperintensity in most cases on T2WI. (8).…”

Section: Discussionmentioning

confidence: 99%

Chordoid Glioma of the Third Ventricular with Rare Patterns and Mutation in PRKCA: a case report and review of literature

Ma¹,

zhu

wang

et al. 2020

Preprint

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Background: Chordoid gliomas are rare, low-grade neoplasms of the third ventricle. In the updated 4th edition of the 2016 WHO classification of tumours of the CNS, it described some three less common histological patterns and rare tissue patterns. Case presentation:Here we reported a case with all the uncommon patterns. It was a 52-year-old woman with dizziness and blurred vision. Imaging showed a solid tumor located in the third ventricle with a well-circumscribed border. Histological, almost tumor cells formed into atypical glands with different sizes and irregular shapes in an abundant of solid or loosely collagen matrix. Some tumor cells formed into papillary patterns, micro-papillary patterns. pseudoglandular patterns. Some focal tumor cells were spindle-shape. Only few epithelioid tumor cells formed into clusters and cords embedded into a myxoid stroma like the chordoma. No anaplastic features were identified in any lesion. Immunohistochemically, all the tumor cells were strong reactivity for TTF-1. Some tumor cells strong but focal reactivity for GFAP, NEU-N, and CD34. It showed a recurrent D463H missense mutation in PRKCA. All these findings confirm that the diagnosis was chordoid glioma of the third ventricular. Conclusions: There may be lots of histopathological features in one chordoid glioma case. It maybe suggested that PRKCA D463H mutation and TTF-1 positive may help to diagnose it.

show abstract

Chordoid glioma: an entity occurring not exclusively in the third ventricle

Cited by 13 publications

References 28 publications

Incidental Third Ventricular Chordoid Glioma: Case Report

Incidental Third Ventricular Chordoid Glioma: Case Report

Chordoid Glioma of the Third Ventricular with Three less Common Patterns and Three Rare Patterns

Chordoid Glioma of the Third Ventricular with Rare Patterns and Mutation in PRKCA: a case report and review of literature

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