Chordoid meningioma: report of 5 cases and review of the literature

Tahta, Alican; Genç, Berkhan; Çakır, Aslı; Şekerci, Zeki

doi:10.1080/02688697.2020.1861436

Cited by 8 publications

(8 citation statements)

References 24 publications

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“…Current literature regarding CM and CCM consists of isolated case reports and a small number of institutional series. To the best of our knowledge, only 22 studies with 423 CM cases have been reported until now [4][5][6][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] while less than 20 studies reported the outcomes of CCM. Owing to the limited case numbers of CM and CCM, few studies have comprehensively investigated the clinical, pathological, and prognosis differences among these 3 histological subtypes of grade 2 meningiomas.…”

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confidence: 99%

Favorable Long-Term Outcomes of Chordoid Meningioma Compared With the Other WHO Grade 2 Meningioma Subtypes

et al. 2022

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BACKGROUND:WHO grade 2 meningiomas, including atypical, chordoid, and clear cell subtypes, form a heterogenous group of meningiomas with varying aggressiveness and clinical behavior.OBJECTIVE:To demonstrate the differences of clinical-histopathological characteristics and long-term outcomes among these 3 subtypes.METHODS:A total of 609 consecutive patients diagnosed with WHO grade 2 meningiomas (543 atypical meningiomas [AMs], 36 chordoid meningiomas [CMs], and 30 clear cell meningiomas [CCMs]) from 2010 to 2018 were enrolled in this study. We compared the clinical-histopathological characteristics and long-term outcomes in these 3 subtypes and assessed survival differences among the subtypes. Targeted panel sequencing of meningioma-relevant genes was performed in the cases of CM.RESULTS:The patients with CCM were significantly younger than those with AM (P < .001) and CM (P = .016). CMs were more likely to receive gross total resection than AMs and CCMs (P = .033). The Ki-67 index was lower (P < .001) while the progesterone receptors-positive rate was higher (P = .034) in CM than in AM and CCM. Importantly, survival analysis demonstrated that CM had better progression-free survival (P = .022) and overall survival (P = .0056) than non-CM tumors. However, the PFS of CM was still worse than WHO grade 1 meningiomas (P < .001). Alterations in NF2 (20.6%) and KMT2C (26.5%) were associated with poorer PFS in CM (P = .013 for NF2; P = .021 for KMT2C).CONCLUSION:Patients with CM had better long-term postoperative outcomes than the other WHO grade 2 subtypes. A lower Ki-67 index, higher PR status, higher extent of resection, and lower frequency of NF2 alteration might contribute to favorable clinical outcomes of CM.

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confidence: 99%

Favorable Long-Term Outcomes of Chordoid Meningioma Compared With the Other WHO Grade 2 Meningioma Subtypes

et al. 2022

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“…Since the risk of recurrence in patients with CM is high, careful follow-up should be recommended for each patient. When Simpson grade ≥II resection cannot be achieved, adjuvant radiotherapy is recommended after surgery ( 11 , 29 , 30 ). In the present case, the immediate resolution of fever post-surgery may be associated with the removal of the tumor, which may be the main source of pyrogens.…”

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confidence: 99%

Lateral ventricle chordoid meningioma presenting with inflammatory syndrome in an adult male: A case report

Zhang

et al. 2023

Exp Ther Med

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Chordoid meningioma (CM) is a rare type of intracranial tumor. Intraventricular CM presenting with inflammatory syndrome is also rare. Meningioma is uncommonly accompanied by fever. The present case report documents a 28-year-old male who was admitted to the Affiliated Taian City Central Hospital of Qingdao University (Taian, China) with a 7-day history of unexplained fever and a 3-day history of progressive headache, which was accompanied with blurred vision in the right eye. Laboratory findings revealed an inflammatory condition with increased C-reactive protein levels, elevated erythrocyte sedimentation rate and moderate leukocytosis. MRI also revealed a lesion located in the right lateral ventricle. Subsequently, the tumor was excised through the right transtrigone lateral ventricle route and the tumor was then completely removed. H&E staining revealed characteristic cords of meningeal epithelial cells embedded in a prominent myxoid background, with numerous lymphocytes and plasma cells surrounding the tumor. Immunohistochemical analysis indicated focal positive staining for epithelial membrane antigen and S100, and negative staining for glial fibrillary acidic protein. Following pathological examination, the tumor was identified to be a CM. During the early postoperative course, the clinical symptoms disappeared and the hematological values returned to normal. No evidence of tumor recurrence was observed after 24 months of follow-up. To the best of our knowledge, the present study was the second to report the case of an adult patient with lateral ventricle CM presenting with inflammatory syndrome and it was the first case in an adult male.

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“…Chordoid meningiomas, a WHO grade 2 meningioma, are known for their rarity and aggressive nature, with 42% of cases showing 1 or more recurrences postoperatively. 1,2 Although PET imaging with radiolabeled somatostatin analogs like 68 Ga-DOTATATE and 68 Ga-DOTATOC has been widely utilized in diagnosing and determining tumor burden for well-differentiated meningioma recurrence based on somatostatin receptor subtype 2 positivity, 18 F-FDG PET imaging may play an important role in detecting recurrence and metastasis in selected patients with high-grade atypical and aplastic meningiomas. [3][4][5][6] Therefore, given its high predilection to recur and metastasize, recognition of chordoid meningioma is preeminent, and an understanding of its behavior is crucial in dictating follow-up.…”

Section: Figurementioning

confidence: 99%

68Ga-DOTATATE and 18F-FDG PET Imaging of a Rare Chordoid Meningioma With Intracranial Recurrence and Extracranial Metastases

Smith,

Lang,

Donev

et al. 2024

Clin Nucl Med

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Chordoid meningiomas, rare meningioma variants, are characterized by their histopathological features and clinical behavior resembling that of other chondroid/myxoid neoplasms. We present a case of pathology-proven chordoid meningioma imaged with both 68Ga-DOTATATE and 18F-FDG PET images during a complicated postoperative course with multiple episodes of local recurrence and, ultimately, extracranial metastasis. This case underscores the aggressive behavior of chordoid meningiomas while highlighting how molecular imaging plays an important role in clinical monitoring and guidance of management.

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Chordoid meningioma: report of 5 cases and review of the literature

Cited by 8 publications

References 24 publications

Favorable Long-Term Outcomes of Chordoid Meningioma Compared With the Other WHO Grade 2 Meningioma Subtypes

Favorable Long-Term Outcomes of Chordoid Meningioma Compared With the Other WHO Grade 2 Meningioma Subtypes

Lateral ventricle chordoid meningioma presenting with inflammatory syndrome in an adult male: A case report

68Ga-DOTATATE and 18F-FDG PET Imaging of a Rare Chordoid Meningioma With Intracranial Recurrence and Extracranial Metastases

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