Chordoma Arising from Cranial Base Extending to Oropharynx: An Unusual Presentation

Vasudevan, Vijeev; Manjunath, V; Devaraju, D; Murali, R

doi:10.1007/s12663-012-0345-y

Cited by 5 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To the best of our knowledge, there have only been 20 reported cases of this type of tumor in the medical literature ( 26 ). Late diagnosis is due to the non-specific and insidious onset of signs and symptoms and the slow growth rate of the tumor ( 13 , 25 ), which is typically only detected when it has grown to a size large enough to cause a notable effect to the surrounding tissues. In the present case report, the patient presented with cranial neuropathies, pain and difficulty swallowing.…”

Section: Discussionmentioning

confidence: 99%

“…Postoperative radiotherapy with photon or proton beam currently serves an important role in chordoma management and has been reported to show a positive outcome ( 2 , 4 , 13 , 19 ). Radiotherapy for head and neck cancer, such as in the present case report, is a challenging task due to the complex anatomy of the head and neck region, with these tumors being located in close proximity to radiation dose-limiting critical structures.…”

Section: Discussionmentioning

confidence: 99%

“…Chordomas are amenable to complete surgical removal if there is no involvement of major neurovascular structures ( 11 , 12 ). The silent onset of these tumors and lack of specific initial symptoms may prevent early diagnosis and, although these tumors may appear benign, local invasion and metastatic spread indicate that they behave more like malignant tumors ( 13 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Radiotherapy of extraosseous nasopharyngeal chordoma: A case report and literature review

Yeh

2021

Mol Clin Oncol

View full text Add to dashboard Cite

Chordomas are slow-growing aggressive tumors that account for 1-4% of all bone tumors. The anatomical distribution of chordomas includes 50-60% in the sacrococcygeal region, 25-30% in the skull base and 15% in the mobile spine. Virchow was the first to describe and term these tumors as ‘ecchordosis physaliphora’ in 1857, and Muller established their notochordal origin in 1895. Extraosseous chordomas of the nasopharynx are very rare, and they exhibit similarities with other lesions of the nasopharynx, presenting as a soft tissue mass. Gross total resection combined with postoperative radiotherapy offers the best chance of long-term control. We herein present the case of a 63-year-old female patient with complaints of left temporal headaches, dizziness, left nasal obstruction, left maxillary area numbness, left ear hearing loss and swallowing difficulty. Computed tomography imaging examination revealed an 8.2x3.2x5.7-cm space-occupying lesion with central necrosis in the nasopharynx and oropharynx, partially occluding the pharyngeal lumen; the mass had infiltrated the left parapharyngeal space, the left medial and lateral pterygoid muscle and the left parotid gland, with bone erosion of the left mandible. The patient was diagnosed with extraosseous chordoma of the nasopharynx, conventional type, stage IIB. The patient underwent surgery and high-dose radiotherapy and local control of the chordoma was achieved. However, the patient succumbed to a lung metastasis. The details of the case are discussed, and a review of the current medical literature is presented to provide an updated discussion on the current status of nasopharyngeal chordoma research.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Radiotherapy of extraosseous nasopharyngeal chordoma: A case report and literature review

Yeh

2021

Mol Clin Oncol

View full text Add to dashboard Cite

show abstract

“…Chordomas located in an atypical position are called ectopic chordomas, such as OCs. The morbidity rate associated with chordomas is approximately 0.2% of all nasopharyngeal and oropharyngeal masses, [ 3 ] and they most commonly occur in 50- to 60-year-old patients; however, Naka et al [ 4 ] reported the occurrence of chordomas in patients 4 to 80 years old with a median age of 51 years. OCs have been sporadically reported in the literature, with the first report originating in 1959.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of oropharyngeal chordoma

Wang

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Chordomas are rare malignant neoplasms derived from incomplete regression of notochordal tissue along the cranio-coccygeal axis. Chordomas that develop in an atypical position are called ectopic chordomas, such as oropharyngeal chordomas (OCs). OCs are exceedingly rare; only 11 cases have been reported to date. Preoperative diagnosis is challenging, and an accurate diagnosis thus is based on postoperative pathologic examination findings and immunohistochemistry. Although surgical therapy and radiotherapy is performed in some patients, the 5-year survival rate is low. Increasingly more studies of chordomas have been based on molecular biology to increase the survival rate, and targeted therapy could be a new therapy in the future.Patient concerns:The patient presented with a left oropharyngeal mass that had begun slowly enlarging 1 year previously. He reported a foreign body sensation and dysphonia during this time period.Diagnoses:The patient was initially diagnosed with a neurogenic tumor. Routine postoperative pathology showed that the mass was consistent with a chordoma.Intervention:Mass resection was performed.Outcome:One year after the initial surgery, magnetic resonance imaging revealed block signal images at the left retropharyngeal space and clivus. The patient developed recurrence of the OC.Lessons:Surgical resection is the mainstay of treatment for OC, and postoperative adjuvant radiotherapy is also important. An understanding of the unusual case described in this report may be helpful in diagnosing OC, and development of targeted therapy may help clinicians to provide novel treatment for patients with OC.

show abstract

“…Bulundukları anatomik bölgeye göre sakrokoksigeal, sfenooksipital veya vertebral olarak sınıflandırılırlar. Kordomanın en sık görüldüğü bölge sakrumdur; kafa tabanı, klivus bölgesi ikinci en yaygın anatomik bölgedir 2 . Servikal bölge yerleşimli kordomalar oldukça nadir görülmektedirler.…”

Section: Introductionunclassified

Yutma güçlüğüne neden olan retrofarengeal kitle: servikal kordoma

Yıldırım¹,

Ocak²,

Akbulut

et al. 2019

Cukurova Medical Journal

View full text Add to dashboard Cite

ÖzChordomas are rare primary bone tumors tought to originate from embryological remnants of the notochord. Upper cervical spine chordomas constitute about 5% of all chordomas. Extension from upper cervical spine to nasopharynx, oropharynx or parapharyngeal space extremely uncommon in head and neck surgical practice. These tumors present with features of compression of adjacent structures resulting in dysphagia, dyspnea or as a palpable neck mass, oropharyngeal mass. In this case report, chordoma originating from upper cervical spine involving the oropharyx is presented. The difficulty of diagnosis, its radiological features along with surgical findings is discussed. Kordomalar, notokordun embriyolojik artıklarından kaynaklanan nadir primer kemik tümörleridir. Servikal bölge yerleşimli kordomalar oldukça nadir görülmektedir. Tüm kordomaların %5 kadarını oluşturan servikal kordomalar, komşu oldukları parafarengeal bölge, orofarenks gibi anatomik boşluklara uzanım gösterip; boyunda şişlik, orofarenkste kitle, yutma güçlüğü, nefes darlığı benzeri klinik bulgular verebilirler. Bu olgu sunumunda yutma güçlüğü şikayeti ile başvuran ve orofarenkste kitle olarak bulgu veren servikal kordoma olgusunun klinik özellikleri sunulmuş, tanıda yaşanan güçlükler ve cerrahi bulgular tartışılmıştır.

show abstract

Chordoma Arising from Cranial Base Extending to Oropharynx: An Unusual Presentation

Cited by 5 publications

References 11 publications

Radiotherapy of extraosseous nasopharyngeal chordoma: A case report and literature review

Radiotherapy of extraosseous nasopharyngeal chordoma: A case report and literature review

An unusual case of oropharyngeal chordoma

Yutma güçlüğüne neden olan retrofarengeal kitle: servikal kordoma

Contact Info

Product

Resources

About