2019
DOI: 10.1177/1040638719894985
|View full text |Cite
|
Sign up to set email alerts
|

Chordoma of the sacrum of an adult naked mole-rat

Abstract: The naked mole-rat (NMR; Heterocephalus glaber)—a small, eusocial, subterranean rodent native to East Africa—is distinguished by its capability to live long and resist changes associated with the aging process. Notably, a growing amount of research has been dedicated to NMRs’ multifactorial capacity to resist cancer. Since 2016, however, zoos have begun to document various neoplasms in a handful of individuals. We present herein radiographic, gross anatomic, and histopathologic features of a case of a sacral c… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
9
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
6
2
1
1

Relationship

0
10

Authors

Journals

citations
Cited by 15 publications
(9 citation statements)
references
References 18 publications
(24 reference statements)
0
9
0
Order By: Relevance
“…This provides clear evidence of the cancer resistance properties of NMRs; however, to the best of our knowledge, it is the only evidence to date of their cancer resistance in vivo. Recently, however, some cases of NMR tumours including metastatic cancer have been reported 5 7 . Therefore, it is unclear how strongly NMR individuals are resistant to carcinogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…This provides clear evidence of the cancer resistance properties of NMRs; however, to the best of our knowledge, it is the only evidence to date of their cancer resistance in vivo. Recently, however, some cases of NMR tumours including metastatic cancer have been reported 5 7 . Therefore, it is unclear how strongly NMR individuals are resistant to carcinogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…Other causes of death or euthanasia included generalized debilitation (3/27; 11%), pulmonary disease (2/27; 7%), gastrointestinal disease (2/27; 7%), nontraumatic skeletal lesions (2/27; 7%), and a spinal tumor (1/27; 3%). 6 The true incidence of the lesions in all aging NMRs reported in this study could not be confirmed due to lack of uniform brain sectioning protocols for zoo NMRs.…”
mentioning
confidence: 70%
“…Delaney et al (2013) also reported no tumours in 138 necropsies of naked mole-rats that had died in zoos. However, Delaney et al 2016 Milone, & Rodriguez (2016) reported one presumptive and four spontaneous cases of neoplasia, and Cole et al (2020) reported one further case. Naked mole-rats do appear to be cancer-resistant compared to similar-sized laboratory mice, which have cancer rates approaching 90% (Lipman et al, 2004).…”
Section: Development Longevity Ageing and Senescencementioning
confidence: 98%