Chordoma

Firooznia, Hossein; Pinto, Richard S.

doi:10.1007/978-3-642-81157-9_10

Cited by 2 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The structural modifications (see Fig. (12)) of Fadrozole (WO04014914 [99] and WO04046145 [100]) mainly consisted in the introduction of a nitrogen in position 7 and an oxo-substitution in position 6. Various substituents were introduced in position 7, as depicted in Fig.…”

Section: Inhibition Of Aldosterone Synthasementioning

confidence: 99%

Inhibitors of Steroidal Cytochrome P450 Enzymes as Targets for Drug Development

Baston¹,

Leroux

2007

PRA

View full text Add to dashboard Cite

Cytochrome P450's are enzymes which catalyze a large number of biological reactions, for example hydroxylation, N-, O-, S- dealkylation, epoxidation or desamination. Their substrates include fatty acids, steroids or prostaglandins. In addition, a high number of various xenobiotics are metabolized by these enzymes. The enzyme 17alpha-hydroxylase-C17,20-lyase (P450(17), CYP 17, androgen synthase), a cytochrome P450 monooxygenase, is the key enzyme for androgen biosynthesis. It catalyzes the last step of the androgen biosynthesis in the testes and adrenal glands and produces androstenedione and dehydroepiandrosterone from progesterone and pregnenolone. The microsomal enzyme aromatase (CYP19) transforms these androgens to estrone and estradiol. Estrogens stimulate tumor growth in hormone dependent breast cancer. In addition, about 80 percent of prostate cancers are androgen dependent. Selective inhibitors of these enzymes are thus important alternatives to treatment options like antiandrogens or antiestrogens. The present article deals with recent patents (focus on publications from 2000 - 2006) concerning P450 inhibitor design where steroidal substrates are involved. In this context a special focus is provided for CYP17 and CYP19. Mechanisms of action will also be discussed. Inhibitors of CYP11B2 (aldosterone synthase) will also be dealt with.

show abstract

Section: Inhibition Of Aldosterone Synthasementioning

confidence: 99%

Inhibitors of Steroidal Cytochrome P450 Enzymes as Targets for Drug Development

Baston¹,

Leroux

2007

PRA

View full text Add to dashboard Cite

show abstract

“…Arising from notochord remnants, chordomas are rare, slow-growing malignancies that have varied clinical presentations due to gradual invasion and destruction of adjacent structures [1] . Vascular involvement is associated with poorer overall survival of sacral chordoma [2] .…”

Section: Introductionmentioning

confidence: 99%