Chordomas: Histopathological Study in View of Anatomical Location

Jin, Yoon; Suh, Yeon Lim

doi:10.3346/jkms.2019.34.e107

Cited by 16 publications

(20 citation statements)

References 25 publications

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“…It can appear at any location along axial skeleton. The sacrococcygeal region is the most common site, accounting for 65% of all cases of chordomas, followed by the spheno-occipital/nasal (25%), cervical (10%), and thoracolumbar (5%) spines [14]. Because of the slow growing rate and the often nonspecific nature of symptoms, chordoma often appears to be an enlarged mass at the time of presentation [15].…”

Section: Discussionmentioning

confidence: 99%

Results following surgical resection of recurrent chordoma of the spine: experience in a single institution

et al. 2020

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Background: Chordoma of the spine is a low-grade malignant tumor with vague and indolent symptoms; thus, large tumor mass is encountered at the time of diagnosis in almost cases and makes it difficult for en-bloc freemargin resection. Salvage therapy for recurrent chordoma is very challenging due to its relentless nature and refractory to adjuvant therapies. The aim of this present study was to report the oncologic outcome following surgical resection of chordoma of the spine. Materials and methods: Retrospective review of 10 consecutive cases of recurrent chordoma patients who underwent surgical treatment between 2003 and 2018 at one tertiary-care center was conducted. Results: There were 10 patients; 4 females and 6 males were included in this study. Eight patients had local recurrence. The recurrence was encountered at the muscle, surrounding soft tissue, and remaining bony structure. Distant metastases were found in 2 patients. The median time to recurrence or metastasis was 30 months after first surgery. Conclusion: En-bloc free-margin resection is mandatory to prevent recurrence. The clinical vigilance and investigation to identify tumor recurrent should be performed every 3 to 6 months, especially in the first 30 months and annually thereafter. Detection of recurrent in early stage with a small mass may be the best chance to perform an en-bloc marginfree resection to prevent further recurrence.

show abstract

Section: Discussionmentioning

confidence: 99%

Results following surgical resection of recurrent chordoma of the spine: experience in a single institution

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It can appear at any location along axial skeleton. The sacrococcygeal region is the most common site, accounting for 65% of all cases of chordomas, followed by the spheno-occipital/nasal (25%), cervical (10%), and thoracolumbar (5%) spines (14). Because of the slow growing rate and the often nonspeci c nature of symptoms, chordoma often appears to be an enlarged mass at the time of presentation (15).…”

Section: Discussionmentioning

confidence: 99%

Results Following Surgical Resection of Recurrent Chordoma Of the Spine: Experience in a Single Institution

Chanplakorn

Lertudomphonwanit

Homcharoen

et al. 2020

Preprint

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Background: Chordoma of the spine is a low-grade malignant tumor with vague and indolentsymptoms thus large tumor mass is encountered at the time of diagnosis in almost cases and makes a difficult for En-bloc free-margin resection. Salvage therapyfor recurrent chordoma is very challenging due to its relentless nature and refractory to adjuvant therapies. The aim of this present study was to report the oncologic outcome following surgical resection of chordoma of the spine.Materials and Methods:Retrospective review of 10 consecutive cases of recurrent chordoma patients who underwent surgical treatment between 2003 and 2018atone tertiary-care center was conducted.Results: There were 10 patients, 4 females and 6 males were included in this study. Eight patients had local recurrence. The recurrence was encountered at the muscle, surrounding soft tissue and remaining bony structure. Distant metastaseswere found in 2 patients. The average time of recurrence was 28 months after first surgery. Conclusion:En-bloc free margin resection is mandatory toprevent recurrent. The clinical vigilance and investigation to identify tumor recurrent should be obtained periodically,in the first 28 months. Detection of recurrent in early stage with a small mass may be the best chance to perform an En-Bloc margin free resection to prevent further recurrent.

show abstract

“…It can appear at any location along axial skeleton. The sacrococcygeal region is the most common site, accounting for 65% of all cases of chordomas, followed by the spheno-occipital/nasal (25%), cervical (10%), and thoracolumbar (5%) spines (14). Because of the slow growing rate and the often nonspeci c nature of symptoms, chordoma often appears to be an enlarged mass at the time of presentation (15).…”

Section: Discussionmentioning

confidence: 99%

Results Following Surgical Resection of Recurrent Chordoma of the Spine: Experience in a single institution

Chanplakorn

Lertudomphonwanit

Homcharoen

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Chordoma of the spine is a low-grade malignant tumor with vague and indolent symptoms thus large tumor mass is encountered at the time of diagnosis in almost cases and makes a difficult for En-bloc free-margin resection. Salvage therapy for recurrent chordoma is very challenging due to its relentless nature and refractory to adjuvant therapies. The aim of this present study was to report the oncologic outcome following surgical resection of chordoma of the spine. Materials and Methods: Retrospective review of 10 consecutive cases of recurrent chordoma patients who underwent surgical treatment between 2003 and 2018 at one tertiary-care center was conducted. Results: There were 10 patients, 4 females and 6 males were included in this study. Eight patients had local recurrence. The recurrence was encountered at the muscle, surrounding soft tissue and remaining bony structure. Distant metastases were found in 2 patients. The median time to recurrent or metastasis was 30 months after first surgery. Conclusion: En-bloc free margin resection is mandatory to prevent recurrent. The clinical vigilance and investigation to identify tumor recurrent should be performed every 3 to 6 months, especially, in the first 30 months and annually thereafter. Detection of recurrent in early stage with a small mass may be the best chance to perform an En-Bloc margin free resection to prevent further recurrent.

show abstract

Chordomas: Histopathological Study in View of Anatomical Location

Cited by 16 publications

References 25 publications

Results following surgical resection of recurrent chordoma of the spine: experience in a single institution

Results following surgical resection of recurrent chordoma of the spine: experience in a single institution

Results Following Surgical Resection of Recurrent Chordoma Of the Spine: Experience in a Single Institution

Results Following Surgical Resection of Recurrent Chordoma of the Spine: Experience in a single institution

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