Chorioadenoma destruens

Wilson, Richard K.; Hunter, James S.; Symmonds, Richard E.; Dockerty, M D; Albert, Alexander; Bulbulian, Arthur H.

doi:10.1016/s0002-9378(15)33670-x

Cited by 37 publications

(13 citation statements)

References 4 publications

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“…4 Direct vascular invasion and metastasis rarely occurs in invasive moles, the most common site reported is the lung. 5,6 The more dreaded complication of lung infiltration by the trophoblastic tissue was however not seen in this patient but there was a 15-20% chance of lung involvement, which either regress completely after evacuation or responds to chemotherapy single or multiple agents. 7 …”

Section: Discussionmentioning

confidence: 63%

Invasive mole presenting as acute abdomen- a case report

Peea

2017

Mediscope

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Gestational trophoblastic neoplasms include the tumour spectrum of hydatidiform mole (complete and partial), invasive mole, (chorioadenoma destruens), placental site trophoblastic tumour and choriocarcinoma. Here a case is reported as invasive hydatidiform mole presenting as an acute haemoperitoneum. The patient presented with acute abdominal pain and signs of haemoperitoneum. Emergency laparatomy releaved a perforating molar pregnancy, resulting in massive haemoperitoneum. Total hysterectomy was done, 5 units blood were transfused. Serum _HCG levels regress quickly and spontaneously.Mediscope Vol. 4, No. 1: Jan 2017, Page 38-39

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Section: Discussionmentioning

confidence: 63%

Invasive mole presenting as acute abdomen- a case report

Peea

2017

Mediscope

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“…Invasive mole may perforate through the myometrium resulting in uterine perforation and intraperitoneal bleeding. 9 Direct vascular invasion and metastasis rarely occurs in invasive moles, the most common site reported is the lung although an invasive mole is generally less malignant than choriocarcinoma, 10 it may be associated with fatal metastasis. Some degree of myometrial trophoblastic invasion is probably present in most moles; indeed, myometrial invasion is not exclusive to molar pregnancies.…”

Section: Discussionmentioning

confidence: 99%

Rare Presentation of Chorioadenoma Destruens as Acute Haemoperitoneum Mimicking Ruptured Ectopic Pregnancy

Sinha

Kaur

Gupta

et al. 2015

Kathmandu Univ. Med. J.

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Gestational trophoblastic neoplasms (GTN) are proliferative degenerative disorders of placental elements and include complete or partial mole (90%), invasivemole (5-8%), choriocarcinoma (1-2%) and placental site tumor (1-2%). Chorioadenoma destruens is a trophoblastic tumor, characterized by myometrial invasion through direct extension or via venous channels. We present a case of invasive mole eroding uterus and uterine vasculature, causing sudden rupture of uterus with massive haemoperitoneum mimicking ectopic pregnancy. A 20 year old G1P0 at 6 weeks gestation presented in Casualty of Kasturba Hospital complaining of severe acute onset lower abdominal pain for one hour. Clinical examination revealed shock. Sonography suggested ectopic pregnancy and immediate exploratory laparotomy was decided. On laparotomy, 2000cc of haemoperitoneum was noted. Grape like vesicles protruding through fundal perforation with profuse active bleeding was seen. Bleeding persisted despite evacuation.Step wise uterine devascularisation failed to achieve haemostasis. Total abdominal hysterectomy was performed as a life saving measure.

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“…Invasive mole may perforate through the whole thickness of the myometrium resulting in uterine perforation and intraperitoneal bleeding (3) . Distant metastasis also rarely occurs in invasive moles, the most common site involved is the lung (4,5) . Uterine evacuation and curettage is the treatment of choice in most of the cases but in some rare cases with intractable bleeding, hysterectomy may be required.…”

Section: Discussionmentioning

confidence: 99%