Chorioamnionitis and inflammation of the fetal lung

Schmidt, Beate; Cao, Lei; Mackensen-Haen, S; Kendziorra, Heide; Klingel, Karin; Speer, Christian P.

doi:10.1067/mob.2001.13321

Cited by 73 publications

(52 citation statements)

References 24 publications

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“…Second, pMw also may be recruited to other sites of fetal inflammation, such as the fetal lungs or membranes, especially in cases of infection of the fetus or amniotic fluid. Supporting this hypothesis, increased numbers of CD68 + macrophages have been reported in fetal lungs during CA (55). The most striking finding of the immunohistochemical analysis in CA patients was the increased expression of CD163 in stage III placentas as compared with stage II placentas and in those with documented infection.…”

Section: Discussionsupporting

confidence: 56%

Placental Macrophages Are Impaired in Chorioamnionitis, an Infectious Pathology of the Placenta

Amara

Gorvel

Baulan

et al. 2013

The Journal of Immunology

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Pregnancy is dependent on maternal–fetal tolerance that may be compromised because of infections or inflammation of the placenta. In this study, we examined whether the context of placental immune tolerance affected the functions of resident macrophages and if their functions were altered during chorioamnionitis, an infectious pathology of the placenta. Macrophages from at-term placentas expressed CD14, exhibited macrophage microbicidal functions, but were less inflammatory than monocyte-derived macrophages. Moreover, placental macrophages spontaneously matured into multinucleated giant cells (MGCs), a property not exhibited by monocyte-derived macrophages, and we detected MGCs of myeloid origin in placental tissue. Compared with placental macrophages, MGCs exhibited a specific phenotype and gene expression signature, consisting of increased cytoskeleton-associated gene expression along with depressed expression of inflammatory response genes. Furthermore, placental macrophages from patients with chorioamnionitis were unable to form MGCs, but this defect was partially corrected by incubating these placental macrophages with control trophoblast supernatants. MGCs formation likely serves to regulate their inflammatory and cytocidal activities in a context that imposes semiallograft acceptance and defense against pathogens.

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Section: Discussionsupporting

confidence: 56%

Placental Macrophages Are Impaired in Chorioamnionitis, an Infectious Pathology of the Placenta

Amara

Gorvel

Baulan

et al. 2013

The Journal of Immunology

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“…7 This inflammatory response may be initiated antenatally by chorioamnionitis and/or sustained by postnatal interventions such as resuscitation, oxygen toxicity and mechanical ventilation with baro-or volutrauma. [8][9][10] This hypothesis was derived from the analyses of tracheal aspirates from ventilated preterm babies and lung tissue from preterm infants who died. [10][11][12] Few large studies have correlated chorioamnionitis with lung outcomes.…”

Section: Antenatal Inflammationmentioning

confidence: 99%

Antenatal inflammation and lung injury: prenatal origin of neonatal disease

Kramer¹

2008

J Perinatol

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“…31 A pronounced IL-8 mRNA-expression could also be detected in the bronchoalveolar epithelium and in a scattered pattern in the interstitial tissue of post-mortem lung tissue of infants with RDS. 32 The increased levels and enhanced mRNA expression of proinflammatory cytokines present in the airways and pulmonary tissue of preterm infants may reflect an inability to regulate inflammation through an adequate expression of the antiinflammatory cytokines IL-10, IL-4, IL-12 and IL-13 or IL-1 receptor antagonist. 26,33 -35 Cellular IL-10 mRNA was undetectable in most airway samples of preterm infants with RDS, but it was expressed in all cell samples of term infants with meconium aspiration syndrome.…”

Section: Inflammatory Cells Endothelial Interactions and Chemotaxismentioning

confidence: 99%

“…48 By now, a pronounced inflammatory response reflected by a marked infiltration of inflammatory cells, increased expression of IL-8 mRNA, and increased apoptosis, has been demonstrated in lung tissue of human fetuses exposed to chorioamnionitis. 32,49 Epidemiological data suggest a strong association between chorioamnionitis and the development of BPD, and increased concentrations of proinflammatory cytokines in human amniotic fluid and fetal cord blood -indicating a systemic inflammatory response during chorioamnionitis -were shown to be an independent risk factor for the development of BPD. 50,51 Furthermore, chorioamnionitis, mechanical ventilation, and postnatal sepsis have clearly been identified as modulators of BPD.…”

Section: Inflammatory Cells Endothelial Interactions and Chemotaxismentioning

confidence: 99%

Pulmonary inflammation and bronchopulmonary dysplasia

Speer

2006

J Perinatol

131

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Various pre-and postnatal risk factors, which act additively or synergistically induce an injurious inflammatory response in the airways and the pulmonary interstitium of preterm infants with bronchopulmonary dysplasia. This inflammatory response is characterized by an accumulation of neutrophils and macrophages as well as an arsenal of proinflammatory mediators that affect the endothelium and alveolar-capillary integrity. Besides proinflammatory cytokines and toxic oxygen radicals, lipid mediators as well as potent proteases may be responsible for acute lung injury. There is increasing evidence that an imbalance between pro-and anti-inflammatory factors, which should protect the alveoli and lung tissue, are key features in the pathogenesis of bronchopulmonary dysplasia. In addition, a subnormal generation of growth factors may affect alveolarization and vascular development in preterm infants with bronchopulmonary dysplasia. In this condensed review article, the current concepts on the possible role of inflammation in the evolution of bronchopulmonary dysplasia will be summarized.

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Chorioamnionitis and inflammation of the fetal lung

Cited by 73 publications

References 24 publications

Placental Macrophages Are Impaired in Chorioamnionitis, an Infectious Pathology of the Placenta

Placental Macrophages Are Impaired in Chorioamnionitis, an Infectious Pathology of the Placenta

Antenatal inflammation and lung injury: prenatal origin of neonatal disease

Pulmonary inflammation and bronchopulmonary dysplasia

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