Chorioamnionitis as a Risk Factor for Cerebral Palsy

Wu, Yvonne W.; Colford, John M.

doi:10.1001/jama.284.11.1417

Cited by 869 publications

(228 citation statements)

References 68 publications

Supporting

Mentioning

202

Contrasting

Unclassified

Order By: Relevance

“…These reports support the notion that hypotension is associated with PVL, yet some others have reported that hypotension is not associated with PVL (Trounce et al 1988;Perlman et al 1996;Dammann et al 2002;Resch et al 2004). Recent studies of PVL pathogenesis have focused on maternal inflammation such as chorioamnionitis in which cytokine release is thought to play a role (Murphy et al 1995;Perlman et al 1996;Resch et al 2000;Wu and Colford 2000). However, PVL actually developed in our infants 2 to 3 weeks after the onset of LCD.…”

Section: Discussionsupporting

confidence: 82%

Periventricular Leukomalacia with Late-Onset Circulatory Dysfunction of Premature Infants: Correlation with Severity of Magnetic Resonance Imaging Findings and Neurological Outcomes

Kobayashi

Fujimoto

Fukuda

et al. 2006

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

The incidence of late-onset circulatory dysfunction (LCD) of premature infants, which is characterized by sudden hypotension and oliguria, has recently increased in Japan. This condition suddenly occurs after several days of age without obvious causes in preterm infants with stable respiration and circulation. Intravenous steroids frequently improve the hypotension. The main problem with LCD is the subsequent and frequent onset of periventricular leukomalacia (PVL), and neurological development appears to be worse in PVL patients with LCD than those without LCD. The aim of this study was to determine whether the severity of magnetic resonance imaging (MRI) findings and neurological outcomes differ between infants who developed PVL after LCD and those who developed PVL without LCD. We retrospectively studied preterm infants who were delivered at less than 33 weeks of gestation between the years 2000 and 2003. During the study period, 10 and 26 infants developed PVL with and without LCD, respectively. The incidence of severe or moderate MRI findings was significantly higher in PVL patients with LCD (100%) than those without LCD (50%; p < 0.05). The incidence of severe cerebral palsy was 88% in PVL infants with LCD and 43% in PVL infants without LCD ( p < 0.05). Moreover, the incidence of visual disorders was significantly higher in PVL infants with LCD (63%) than those without LCD (9%; p < 0.01). In conclusion,

show abstract

Section: Discussionsupporting

confidence: 82%

Periventricular Leukomalacia with Late-Onset Circulatory Dysfunction of Premature Infants: Correlation with Severity of Magnetic Resonance Imaging Findings and Neurological Outcomes

Kobayashi

Fujimoto

Fukuda

et al. 2006

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…Abnormalities of the cerebellum in mice after exposure to phenobarbital, such as a decrease in the number of Purkinje 37 and granular cells, 33 without an effect on the area of the cerebellum, have been reported. Sepsis, an independent risk factor for a poor neurologic outcome, 25,34,38 could have exerted a detrimental effect on the growth of the cerebellum by diffuse white matter injury, 24 bacterial products and cytokines, 39,40 arterial hypotension, and combined cerebral ischemia. 25 Bronchopulmonary dysplasia, a known risk factor for neurodevelopmental impairment, has also been reported to exert an effect on the granular cells of the cerebellum, as shown in a baboon model.…”

Section: Discussionmentioning

confidence: 99%

Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes

Park

Yoon

Han³

et al. 2013

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

“…Maternal infection has been linked to low Apgar scores, neonatal seizures (Grether & Nelson, 1997), and cerebral palsy (Grether & Nelson, 1997;Wu & Colford, 2000). Other causes of fetal heart rate changes include conditions involving the fetus: sleep cycle; infection; anemia; arrhythmia; preexisting neurologic injury; heart block; and congenital anomalies (Miller & Miller, 2012).…”

Section: Factors Influencing Fetal Heart Rate Changesmentioning

confidence: 99%

Fetal Monitoring: Creating a Culture of Safety With Informed Choice

Heelan¹

2013

J Perinat Educ

View full text Add to dashboard Cite

The dominant culture in labor and birth is the medical model, not the midwifery model of woman-centered care. Consensus among professional and governmental groups is that, based on the evidence, intermittent auscultation is safer to use in healthy women with uncomplicated pregnancies than electronic fetal monitoring (EFM). Barriers impact the laboring woman's ability to give informed choice regarding fetal monitoring. Lack of informed choice denies a woman her right to be in control of her birth experience, and is in opposition to a woman's right to autonomy and self-determination.

show abstract

Chorioamnionitis as a Risk Factor for Cerebral Palsy

Abstract: Our meta-analysis indicates that chorioamnionitis is a risk factor for both cerebral palsy and cPVL. JAMA. 2000;284:1417-1424.

Cited by 869 publications

References 68 publications

Periventricular Leukomalacia with Late-Onset Circulatory Dysfunction of Premature Infants: Correlation with Severity of Magnetic Resonance Imaging Findings and Neurological Outcomes

Periventricular Leukomalacia with Late-Onset Circulatory Dysfunction of Premature Infants: Correlation with Severity of Magnetic Resonance Imaging Findings and Neurological Outcomes

Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes

Fetal Monitoring: Creating a Culture of Safety With Informed Choice

Contact Info

Product

Resources

About