Chorioamnionitis in relation to gestational outcome in a Swedish population

Nordenvall, Margareta; Sandstedt, Bengt

doi:10.1016/0028-2243(90)90050-b

Cited by 16 publications

(12 citation statements)

References 16 publications

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“…Suspected chorioamnionitis is one of the perinatal risk factors for which the Centers for Disease Control and the American College of Obstetricians and Gynecologists recommends intrapartum antibiotics for prophylaxis against neonatal sepsis (American College of Gynecology and Obstetrics committee opinion no 279, 2002;Schrag et al, 2002). Pathologically confirmed chorioamnionitis has been shown to be associated with neonatal sepsis and infection (Novak & Platt, 1985;Nordenvall & Sandstedt, 1990;deAraujo, Schultz & Vaz, 1994;Smulian et al, 1999;Elimian et al, 2000;Ogunyemi et al, 2003;Dempsey et al, 2005;Mehta et al, 2006). In addition, chorioamnionitis has been shown to be associated with neonatal mortality independent of other factors such as prematurity (Elimian et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Utility of hematologic and volume, conductivity, and scatter parameters from umbilical cord blood in predicting chorioamnionitis

Lee

Ahern

Cháves³

et al. 2010

Int J Lab Hematology

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We evaluated the utility of routine hematologic parameters and volume, conductivity, and scatter (VCS) parameters from umbilical cord blood in predicting pathologically confirmed chorioamnionitis. Chorioamnionitis is strongly associated with early neonatal sepsis and is the major in utero source of infectious exposure. We prospectively identified mothers who had placenta submitted for pathology and subsequently identified corresponding neonate cord blood sent for routine blood typing (n = 99). Cord blood was then sent for routine complete blood count with differential (CBCD). Among the same neonates, we retrospectively identified those who had peripheral blood sent for CBCD. We collected VCS parameter data, which are used in determining an automated leukocyte differential, from our hematology analyzer. Routine hematologic as well as VCS parameters from both cord and peripheral blood were then evaluated for predicting pathologically confirmed chorioamnionitis. In the study population, the absolute neutrophil count, neutrophil differential, mean neutrophil conductivity, and neutrophil conductivity standard deviation (SD) from cord blood showed the best predictive ability for chorioamnionitis. Among neonates with intrapartum antibiotic prophylaxis exposure, the band differential, immature neutrophil precursor differential, and neutrophil conductivity SD showed the best predictive ability. Lastly, among the neonates who had peripheral blood CBCD, the band differential and immature neutrophil precursor differential showed the best predictive ability. Overall, the peripheral blood band differential and immature neutrophil precursor differential showed better specificity and positive predictive value for chorioamnionitis than the cord blood parameters. However, the cord blood absolute neutrophil count, neutrophil differential, and mean neutrophil conductivity showed better negative predictive value. Cord blood can be a valuable source of diagnostic laboratory testing for neonates because of their small blood volume. This is the first study demonstrating that routine hematologic and VCS parameters from cord blood can be used to predict pathologically confirmed chorioamnionitis.

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Section: Discussionmentioning

confidence: 99%

Utility of hematologic and volume, conductivity, and scatter parameters from umbilical cord blood in predicting chorioamnionitis

Lee

Ahern

Cháves³

et al. 2010

Int J Lab Hematology

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“…Traditionally, the mode of infection in these patients is thought to be hematogenous or transplacen tal. Recently, it has been recognized that IAI, especially subclinical, can occur secondarily to ascending infection in the face of intact membranes [4]. In recent investigations, us ing ACT in evaluation of preterm labor, it has been found that 3-26% of gravidas were cul ture positive with intact membranes [2,9].…”

Section: Discussionmentioning

confidence: 99%

“…Occa sional cases of IAI with intact membranes and without labor support a presumed hematoge nous or transplacental route of infection. Less commonly, IAI may develop as a consequence of obstetric procedures such as cervical cer clage, diagnostic amniocentesis (ACT) and in trauterine transfusion [3][4][5], But until now, Nazir et al [6] were the only who have pub lished the results of microbial analysis of am niotic fluid specimens obtained by serial ACT.…”

Section: Introductionmentioning

confidence: 99%

Risk Estimation of Intraamniotic Infection Development after Serial Amniocentesis

Terzić

Plecas

Štimec³

et al. 1994

Fetal Diagn Ther

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Microbial invasion and growth in amniotic fluid play an important role in infectious perinatal morbidity and mortality. In order to determine the influence of amniocentesis (ACT) on intra-amniotic infection development, we performed a study of 239 complete microbiological examinations of amniotic fluid specimens obtained by serial interventions. In 1 case (0.42%), during the second procedure, Staphylococcus epidermidis was discovered. Neither spontaneous abortion nor preterm labor were provoked by the procedure. We can conclude that ACT has been confirmed as a safe and successful intrauterine intervention if it is made in a proper manner.

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“…The evidences showed the rates of pre-term labor increased from 9.7% in 1990 to more than 10.8% in 2004 in the developed countries (1,2). In Iran, the rate of pre-term labors was estimated about 13.9% (3).…”

Section: Introductionmentioning

confidence: 99%

“…Maternal genital tract colonization with specific organisms can play a role in pre-term delivery. Bacterial products such as phospholipases A 2 and C, endotoxin, and induction of the cytokine cascade can stimulate the prostaglandin pathway and initiate labor (1,2). Even in nonpregnant women, the presence of pathogens in the genitourinary tract has been shown to induce cytokine production (6,7).…”

Section: Introductionmentioning

confidence: 99%