Choriocarcinoma following term pregnancy with bone metastasis

Vani, R.; Rao, Keerthi; Koteshwar, Reshma

doi:10.1016/0020-7292(93)90841-j

Cited by 10 publications

(7 citation statements)

References 1 publication

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“…Table 1 presents all cases of reported spinal metastases found in a comprehensive literature search. [ 1 2 3 4 6 9 10 11 13 14 16 21 22 ] The first three reported cases of spinal choriocarcinoma in other young males all represent cases of advanced multi-system disease burden as in the case reported here. In fact, in two of the three prior cases, the spinal involvement was only found upon autopsy.…”

Section: Discussionmentioning

confidence: 56%

Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature

et al. 2014

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Background:There are few cases of choriocarcinoma metastases to the spine that have been reported. Most occurrences are in women with the gestational form of the tumor, and these now exhibit a very high remission rate with chemotherapeutic treatment, typically circumventing the need for spinal surgery.Case Description:In an effort to better understand treatment options for those rare instances when choriocarcinoma does find its way into the spine, we have synthesized a comprehensive literature review on the clinical cases of choriocarcinoma spinal metastases. We also describe our unique experience and decision-making involving the first reported case of surgical treatment of non-gestational choriocarcinoma spinal metastases in a male patient.Conclusion:Spinal surgery has a limited role in metastatic choriocarcinoma, but there is the potential for improving neurologic decline even in the rare and aggressive male variant of this disease.

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Section: Discussionmentioning

confidence: 56%

Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature

et al. 2014

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“…Since it is very rare, the best treatment for patients with spinal metastasis has not been established. There have been few reported cases of spine metastasis of choriocarcinoma treated with chemotherapy followed by radiation [6,17]. The surgery is usually indicated when there is a massive mass effect due to tumour mass or hematoma.…”

Section: Discussionmentioning

confidence: 99%

Choriocarcinoma with spinal metastasis: a case report

et al. 2021

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Choriocarcinoma is a highly malignant trophoblastic neoplasia, arising following any type of pregnancy. Even though choriocarcinoma has an early haematogenous metastasis to multiple organs, spinal metastasis is extremely rare. A 28-year-old woman presented with a two-week history of progressive numbness and weakness of the lower limbs and difficulty in walking. In magnetic resonance imaging of the spine, soft tissue components were noted adjacent to the spinal cord. She underwent laminectomy to remove the extramedullary located tumour mass, which was compressing the spinal cord. Although there was a significant improvement in tactile stimulation in the lower limb following six courses of multi-agent chemotherapy, she continued to have leg weakness. Despite improvements in treatment modality and the use of combined modality treatment with chemotherapy, surgery, and radiation, the prognosis for this choriocarcinoma with spinal metastasis is unfavourable. Earlier diagnosis and multimodality treatment is crucial for a significant reduction in mortality and morbidity.

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“…Choriocarcinoma often metastasizes hematogenously to the vulvovaginal region, lungs, liver, and brain; however, a bone metastasis is extremely rare . Only six cases of metastasis to the spine have been reported previously, and the prognosis for these cases was poor, despite administration of systematic treatment, including multi‐drug chemotherapy and/or radiation . Menegaz et al reported a patient who showed neurological improvement after EMA/CO chemotherapy and radiotherapy .…”

Section: Discussionmentioning

confidence: 99%

Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy

Ishiguro

Serikawa

Yahata

et al. 2016

J of Obstet and Gynaecol

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Gestational choriocarcinoma metastasizing to the bones, especially to the spine, is extremely rare. In addition, there are few reports of choriocarcinoma during a viable pregnancy. We report a case of gestational choriocarcinoma that metastasized to the lumbar spine during a viable pregnancy in a 41-year-old woman with a history of a missed abortion. A heterogeneous cervical mass was detected at gestational week 16. Subsequently, a metastatic lesion appeared during the pregnancy, and fetal demise in utero occurred. Pathological examination revealed that the cervical tumor and metastatic spinal tumor were choriocarcinoma. The patient's condition deteriorated rapidly and we were unable to save her life, despite multidrug chemotherapy. Surgical tumor resection and pregnancy might involve a substantial risk of choriocarcinoma metastasis. It is important to obtain an early diagnosis for this life-threatening disease in order to facilitate appropriate treatment, despite pregnancy.

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Choriocarcinoma following term pregnancy with bone metastasis

Cited by 10 publications

References 1 publication

Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature

Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature

Choriocarcinoma with spinal metastasis: a case report

Gestational choriocarcinoma: Rare spinal metastasis during a viable pregnancy

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